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STERISHEALTHCARE 573431969ec6680ff811d9bc Products https://www.sterisindia.com
VINOCANAZOL 200Vori
VINOCANAZOL 200Vori
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Dermatology by VINOCANAZOL 200

Voriconazole 200mg Tablet

INR 1642 INR 2345
You Save: INR 703 (29.98%)

Description

Product details

VINOCANAZOL 200 Voriconazole (200mg) In the critical field of infectious disease management, the need for potent, broad-spectrum antifungal agents is paramount. VINOCANAZOLE 200, manufactured by the renowned Steris Healthcare, stands as a premier pharmaceutical solution designed to combat severe and life-threatening fungal infections. Each film-coated tablet of VINOCANAZOL 200 contains Voriconazole 200mg, a second-generation triazole antifungal agent. Unlike standard antifungals used for superficial skin issues, VINOCANAZOL 200 is engineered for systemic depth. It is a lifeline for immunocompromised patients, such as those undergoing organ transplants, chemotherapy, or battling HIV/AIDS, offering a robust defense against aggressive pathogens that resist older medications. By combining high bioavailability with a targeted mechanism of action, VINOCANAZOL 200 ensures that patients receive hospital-grade therapy with the convenience of an oral dosage form, facilitating smoother transitions from intravenous treatments to home-based recovery. Mechanism of Action: How VINOCANAZOL 200 Works To understand the efficacy of VINOCANAZOL 200, one must look at the cellular level of the fungal pathogen. Fungi, like humans, rely on a protective cell membrane to survive. A key structural component of this membrane is a substance called ergosterol (similar to how cholesterol works in human cells). Voriconazole 200mg works by selectively inhibiting a specific enzyme system within the fungus known as cytochrome P450-dependent 14-alpha-sterol demethylase. Blockade: The drug blocks the conversion of lanosterol to ergosterol. Destabilization: Without ergosterol, the fungal cell membrane becomes unstable and permeable. Cell Death: Essential cellular components leak out, and the accumulation of toxic precursor sterols inside the fungal cell leads to the arrest of growth and eventual cell death. What makes VINOCANAZOLE 200 superior to first-generation azoles (like fluconazole) is its broader affinity. It effectively targets molds like Aspergillus—which are often resistant to other treatments—making it a versatile weapon in modern medical mycology. Therapeutic Indications and Uses VINOCONAZOLE 200 is a prescription-only medication indicated for the treatment of adult and pediatric patients (aged 2 years and older) with specific, serious fungal infections. Its clinical applications include: 1. Invasive Aspergillosis This is the primary indication for Voriconazole. It is the 'Gold Standard' first-line treatment for infections caused by Aspergillus species (Aspergillosis). These mold infections typically affect the lungs but can spread to the brain and other organs, particularly in patients with weakened immune systems. 2. Candidemia (Non-Neutropenic) VINOCANAZOL 200 is effective against Candidemia (fungal infection of the blood) and other deep tissue Candida infections (disseminated candidiasis) in patients who have normal white blood cell counts. 3. Esophageal Candidiasis It is prescribed for severe fungal infections of the esophagus (the tube connecting the throat to the stomach), often seen in HIV/AIDS patients where swallowing becomes painful and difficult. 4. Scedosporium and Fusarium Infections These are rare but notoriously difficult-to-treat fungal infections. VINOCANAZOL 200 is one of the few drugs effective against Scedosporium apiospermum and Fusarium species, often used when other therapies have failed. Key Benefits of VINOCANAZOL 200 Choosing VINOCANAZOL 200 by Steris Healthcare offers distinct advantages for both clinicians and patients: Broad-Spectrum Potency: It covers a wider range of pathogens than older antifungals, effective against both yeasts (Candida) and molds (Aspergillus, Fusarium). High Oral Bioavailability: The tablet form has excellent absorption (estimated at 96%), meaning the amount of drug entering the bloodstream is nearly identical to intravenous administration. This allows patients to leave the hospital sooner and continue effective treatment at home. CNS Penetration: Unlike many other antifungals, Voriconazole can cross the blood-brain barrier, making it crucial for treating fungal infections that have spread to the central nervous system. Quality Assurance: Manufactured by Steris Healthcare, the product adheres to strict GMP (Good Manufacturing Practice) standards, ensuring consistent purity, stability, and dosage accuracy in every tablet. Side Effects: What to Expect While VINOCANAZOL 200 is life-saving, it is a potent medication with a specific side-effect profile. Patients must be monitored closely. Common Side Effects Visual Disturbances: This is the most unique side effect of Voriconazole. Approximately 20-30% of patients may experience altered visual perception, blurred vision, or enhanced perception of light (photophobia). This typically occurs around 30 minutes after dosing and is temporary/reversible. Gastrointestinal Issues: Nausea, vomiting, diarrhea, and abdominal pain. Skin Rash: Mild to moderate rashes may occur. Headache and Swelling: Peripheral edema (swelling of legs/arms) or general headaches. Serious Side Effects Hepatotoxicity (Liver Damage): Elevating liver enzymes is a risk. Regular blood tests (Liver Function Tests) are mandatory during treatment to prevent hepatitis or liver failure. Photosensitivity: The drug makes skin highly sensitive to sunlight. Patients can develop severe sunburns even with minimal exposure. Long-term use without sun protection is linked to an increased risk of skin cancer (squamous cell carcinoma). QT Prolongation: It may affect the heart's electrical rhythm. Caution is advised for patients with existing heart conditions. Dosage and Administration Guidelines Note: Always follow the specific instructions of the prescribing Infectious Disease Specialist. Loading Dose: Treatment often begins with a higher 'loading dose' (sometimes given intravenously first or as a higher oral dose) for the first 24 hours to reach therapeutic levels quickly. Maintenance Dose: The standard maintenance dose for adults is one VINOCONAZOLE 200 tablet twice daily (every 12 hours). Administration: Voriconazole absorption is reduced by food. VINOCANAZOL 200 must be taken at least one hour before or one hour after a meal. Missed Dose: If a dose is missed, take it as soon as remembered unless it is near the next scheduled dose. Do not double the dose. Precautions and Drug Interactions VINOCANAZOL 200 interacts with many other medications because it is metabolized by the liver (CYP450 enzymes). Contraindications: It should not be taken with high-dose ritonavir, carbamazepine, rifampin, or St. John’s Wort, as these can critically lower voriconazole levels or lead to toxicity. Pregnancy: It can cause fetal harm. Effective contraception is strictly required for women of childbearing potential during treatment. Driving: Due to potential visual changes (blurring/photophobia), patients should avoid driving or operating machinery, especially at night, until they know how the drug affects them. Conclusion VINOCANAZOL 200 (Voriconazole 200mg) represents the pinnacle of modern antifungal therapy. It fills a critical gap in medicine, offering a powerful oral solution for invasive fungal infections that were once difficult or impossible to treat outside of a hospital setting. By targeting the very structure of fungal cells with precision, VINOCANAZOL 200 halts the progression of disease, allowing the body's immune system to recover. With the backing of Steris Healthcare, patients are assured of a product that balances high-grade pharmaceutical efficacy with accessibility. Whether for treating Invasive Aspergillosis or resistant Candidemia, VINOCANAZOL 200 is a trusted shield against the hidden dangers of fungal pathogens, restoring health and hope to those who need it most.

Other Specifications

Brand Name :VINOCANAZOL 200
Manufactured By :Steris Healthcare Pvt Ltd
Packaging Size :For 4 Tablet
Storage :Store In A Cool & Dry Place
Country of origin :India
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