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TASMULINE DFZ Tamsulosin Hydrochloride 0.4 mg PR & Deflazacort 30 mg The combination of Tamsulosin Hydrochloride 0.4 mg PR and Deflazacort 30 mg is a well-designed therapeutic formulation used primarily in the management of urinary tract disorders, especially conditions associated with inflammation, swelling, and obstruction of urine flow. This dual-action medicine is commonly prescribed in cases such as benign prostatic hyperplasia (BPH), ureteric stones, and post-urological inflammatory conditions, where both muscle relaxation and anti-inflammatory action are required for effective symptom relief. By combining an alpha-1 adrenergic blocker (Tamsulosin) with a corticosteroid (Deflazacort), this formulation addresses both the mechanical obstruction and the inflammatory component, offering faster relief and improved patient comfort. Product Description Tamsulosin Hydrochloride 0.4 mg PR Tamsulosin Hydrochloride is a selective alpha-1A adrenergic receptor blocker. It works by relaxing the smooth muscles of the prostate gland, bladder neck, and urethra, thereby improving urine flow and reducing symptoms such as difficulty in urination, weak stream, incomplete bladder emptying, and frequent urination. The PR (Prolonged Release) formulation ensures: Controlled and sustained release of the drug Consistent blood levels throughout the day Reduced risk of sudden blood pressure drops Improved patient compliance with once-daily dosing Deflazacort 30 mg Deflazacort is a synthetic glucocorticoid with potent anti-inflammatory and immunosuppressive properties. Compared to many other steroids, Deflazacort is known for: Lower impact on bone density Reduced fluid retention Better safety profile when used under medical supervision In urological conditions, Deflazacort helps by: Reducing inflammation and swelling around the urinary tract Decreasing pain and irritation Supporting faster recovery Uses of Tamsulosin Hydrochloride 0.4 mg PR & Deflazacort 30 mg This combination is prescribed in various urological and inflammatory conditions, including: 1. Benign Prostatic Hyperplasia (BPH) Enlargement of the prostate gland can obstruct urine flow and cause discomfort. Tamsulosin relaxes the prostate muscles, while Deflazacort reduces associated inflammation, providing effective symptom relief. 2. Ureteric and Renal Stones In patients with urinary stones, this combination helps: Relax ureteral smooth muscles Reduce inflammation around the stone Facilitate easier and less painful stone passage 3. Post-operative Urological Inflammation After urological surgeries or procedures, inflammation may cause pain and urinary difficulty. Deflazacort controls inflammation, while Tamsulosin supports smooth urination. 4. Urinary Tract Obstruction with Inflammation Conditions involving swelling or irritation of the urinary tract benefit from the dual mechanism of muscle relaxation and inflammation control. Key Benefits of the Combination Dual Mechanism for Better Outcomes Tamsulosin improves urine flow by relaxing smooth muscles Deflazacort reduces swelling, pain, and inflammation Faster Symptom Relief Patients often experience quicker improvement in urinary symptoms compared to single-drug therapy. Improved Patient Comfort Reduction in pain, burning sensation, urinary urgency, and nocturia improves overall quality of life. Prolonged Release Advantage The PR formulation of Tamsulosin ensures steady drug action throughout the day with fewer side effects. Better Tolerability Deflazacort offers steroid benefits with comparatively fewer long-term adverse effects when used appropriately. Dosage and Administration The medicine is usually taken once daily, preferably after the same meal each day Tablets/capsules should be swallowed whole and not crushed or chewed Dosage duration depends on the severity of the condition and should always be as advised by a physician Important: This medicine should only be used under medical supervision, especially due to the presence of a corticosteroid. Possible Side Effects Like all medicines, Tamsulosin Hydrochloride 0.4 mg PR & Deflazacort 30 mg may cause side effects in some patients. Common Side Effects Dizziness or light-headedness Headache Fatigue Nasal congestion Mild stomach upset Increased appetite (due to Deflazacort) Less Common Side Effects Low blood pressure, especially on standing Sleep disturbances Mood changes Indigestion or heartburn Rare but Serious Side Effects Severe allergic reactions Vision disturbances Signs of infection (with prolonged steroid use) Sudden swelling of face or throat Patients should immediately consult a doctor if any severe or unusual symptoms occur. Precautions and Warnings Use cautiously in patients with low blood pressure Not recommended for patients with severe liver impairment unless advised Long-term use of Deflazacort requires monitoring for blood sugar, bone health, and infection risk Patients should not abruptly stop the medicine without medical advice Inform the doctor about any ongoing medications to avoid drug interactions Storage Instructions Store in a cool, dry place Protect from direct sunlight and moisture Keep out of reach of children Conclusion Tamsulosin Hydrochloride 0.4 mg PR & Deflazacort 30 mg is a scientifically balanced combination that offers effective relief from urinary obstruction and inflammation-related symptoms. By targeting both muscle tension and inflammatory swelling, it provides comprehensive management for conditions like benign prostatic hyperplasia, urinary stones, and post-urological inflammation
