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"description": "TENELIGOLD PIO 20/15 \nTeneligliptin & Pioglitazone\nIntroduction\nTENELIGOLD PIO 20/15 combines two antidiabetic medications, Teneligliptin and Pioglitazone, in a single formulation. This combination is designed to manage type 2 diabetes mellitus by targeting different aspects of glucose metabolism, thereby improving glycemic control in patients who are inadequately controlled with monotherapy or require dual therapy.\n\nComposition\n\nTeneligliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucagon release, thereby lowering blood glucose levels.\nPioglitazone: A thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues (muscle and adipose tissue) and reduces hepatic glucose production.\nMechanism of Action\n\nTeneligliptin: Inhibits the degradation of incretin hormones (GLP-1 and GIP), which play a key role in glucose-dependent insulin secretion and suppression of glucagon secretion.\nPioglitazone: Activates peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to improved insulin sensitivity, enhanced glucose uptake in peripheral tissues, and reduced hepatic glucose production.\nIndications\nTENELIGOLD PIO 20/15 is indicated for:\n\nType 2 Diabetes Mellitus: Used to improve glycemic control in adults who are inadequately controlled with diet and exercise alone or with other antidiabetic medications.\nDosage and Administration\n\nThe typical dosage is one tablet of TENELIGOLD PIO 20/15 taken orally once daily, preferably with meals.\nDosage adjustments may be necessary based on individual patient response and tolerability.\nIt is important to adhere to the prescribed dosage regimen to achieve optimal glycemic control.\nSide Effects\nCommon side effects may include:\n\nHypoglycemia (especially when used in combination with insulin or sulfonylureas)\nEdema (fluid retention)\nWeight gain\nHeadache\nNasopharyngitis (common cold)\nMore severe side effects can include:\n\nHeart failure (especially in patients with pre-existing cardiovascular disease)\nHepatic dysfunction (monitor liver function tests periodically)\nBone fractures (especially in women)\nPrecautions\n\nHeart Failure: Use with caution in patients with a history of heart failure or other cardiovascular diseases.\nBladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; therefore, it should be used cautiously in patients with a history of bladder cancer or with risk factors.\nLiver Function: Monitor liver function tests before starting treatment and periodically thereafter, as Pioglitazone may cause hepatic dysfunction.\nPregnancy and Lactation: Use during pregnancy and lactation should be avoided unless the potential benefits outweigh the risks.\nDrug Interactions\n\nInsulin/Sulfonylureas: Increased risk of hypoglycemia when used concomitantly with insulin or sulfonylureas.\nGemfibrozil: May increase Pioglitazone levels, requiring dose adjustment.\nCYP2C8 Inhibitors (e.g., Gemfibrozil): May increase Pioglitazone concentrations, necessitating monitoring for adverse effects.\nConclusion\nTENELIGOLD PIO 20/15 offers a dual-action approach to managing type 2 diabetes mellitus by combining Teneligliptin and Pioglitazone. This combination helps improve glycemic control through different mechanisms: enhancing insulin secretion and sensitivity. It is crucial to use this medication under the guidance of a healthcare professional to optimize treatment outcomes while minimizing the risk of side effects. Regular monitoring for efficacy and safety parameters, including blood glucose levels and potential adverse effects, is essential for managing diabetes effectively with TENELIGOLD PIO 20/15.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n\n",
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"description": "ZENCOBAL 1500 I.V. \nMecobalamin Injection 1500 mcg/ml\nOverview\nZENCOBAL 1500 I.V. is a high-potency injectable solution of Mecobalamin, providing 1500 mcg/ml. Mecobalamin, also known as Methylcobalamin, is a bioactive form of Vitamin B12 essential for nerve function, red blood cell production, and DNA synthesis. This injectable form is particularly beneficial for individuals with severe Vitamin B12 deficiency, absorption issues, or those requiring rapid therapeutic response.\n\nBenefits of Mecobalamin\n\nNeurological Health\n\nEssential for the maintenance and regeneration of myelin sheaths, which protect nerve fibers.\nHelps in the prevention and treatment of neuropathy, which can cause symptoms like tingling, numbness, and pain in the extremities.\nSupports cognitive functions and may improve symptoms in conditions like Alzheimer's disease and other cognitive impairments.\nRed Blood Cell Production\n\nVital for the production of healthy red blood cells, preventing megaloblastic anemia.\nEnhances oxygen transport throughout the body, reducing symptoms of fatigue and weakness.\nDNA Synthesis and Repair\n\nPlays a critical role in the synthesis and repair of DNA, supporting cell division and overall cellular health.\nImportant for rapidly dividing cells, such as those in the bone marrow, skin, and gastrointestinal tract.\nUsage and Dosage\nZENCOBAL 1500 I.V. should be administered under the supervision of a healthcare professional. The dosage and frequency will depend on the severity of the deficiency and the individual's response to treatment. Typically, it may be given as an intramuscular or intravenous injection, ensuring rapid absorption and immediate therapeutic effects.\n\nIndications for Use\n\nVitamin B12 Deficiency: Effective in treating severe deficiencies, particularly in cases where oral supplementation is insufficient.\nPeripheral Neuropathy: Used to alleviate symptoms and promote nerve health in conditions such as diabetic neuropathy, alcoholic neuropathy, and other neuropathic conditions.\nMegaloblastic Anemia: Corrects anemia caused by Vitamin B12 deficiency, improving hemoglobin levels and reducing related symptoms.\nNeurodegenerative Disorders: Supports neurological health and may benefit conditions like multiple sclerosis and amyotrophic lateral sclerosis (ALS).\nSide Effects\nZENCOBAL 1500 I.V. is generally well-tolerated, with minimal side effects. However, some individuals may experience mild reactions at the injection site, such as pain, redness, or swelling. Rarely, systemic reactions like dizziness, headache, or gastrointestinal disturbances may occur. It is important to discuss any pre-existing conditions or medications with a healthcare provider before starting treatment.\n\nPrecautions and Contraindications\n\nAllergic Reactions: Individuals with a known allergy to cobalamin or any component of the injection should avoid use.\nMedical Conditions: Patients with Leber's disease or other hereditary optic neuropathies should use Mecobalamin with caution, as it may exacerbate these conditions.\nPregnancy and Lactation: While Vitamin B12 is crucial during pregnancy and lactation, it is essential to consult a healthcare provider to determine the appropriate dosage and method of administration.\nConclusion\nZENCOBAL 1500 I.V. offers a potent and effective solution for individuals with severe Vitamin B12 deficiency and related conditions. By providing a high dose of bioactive Mecobalamin, this injectable form ensures rapid absorption and immediate therapeutic benefits, supporting neurological health, red blood cell production, and overall cellular function. Under the guidance of a healthcare professional, ZENCOBAL 1500 I.V. can play a critical role in addressing deficiencies, alleviating symptoms, and improving the quality of life for those in need.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n",
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