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"description": "GLIDAPA TENE 10/20 \nDapagliflozin & Teneligliptin\nIntroduction\nGLIDAPA TENE 10/20 is a cutting-edge oral medication engineered for the management of Type 2 diabetes. This combination therapy includes Dapagliflozin (10 mg) and Teneligliptin (20 mg), two powerful drugs that work synergistically to control high blood sugar levels effectively.\n\nHow It Works\n\nDapagliflozin (10 mg): Dapagliflozin belongs to the class of drugs known as SGLT2 inhibitors. It works by preventing the kidneys from reabsorbing glucose back into the blood, promoting the excretion of glucose through urine. This leads to a reduction in blood glucose levels and can also aid in weight loss and blood pressure control.\nTeneligliptin (20 mg): Teneligliptin is a DPP-4 inhibitor that enhances the body's natural ability to lower blood sugar levels by increasing the release of insulin and decreasing the release of glucagon after meals. This helps to smooth out blood sugar spikes that can occur post-meal.\nBenefits\nGLIDAPA TENE 10/20 offers a comprehensive approach to diabetes management by targeting different pathways in glucose metabolism. The combination of Dapagliflozin and Teneligliptin provides a dual mechanism of action, which can be more effective in lowering blood glucose levels compared to monotherapy. This can also lead to improvements in HbA1c levels, a key indicator of long-term glycemic control.\n\nDosage and Administration\n\nDosage: The standard dosage is one tablet per day, but it should be adjusted based on the patient's specific medical condition, tolerance, and the effectiveness of the treatment.\nAdministration: GLIDAPA TENE 10/20 should be taken in the morning with or without food. Consistent daily intake helps maintain stable drug levels in the blood and ensures maximum efficacy.\nSide Effects\nThe most common side effects associated with GLIDAPA TENE 10/20 may include urinary tract infections due to the increased glucose in urine, and gastrointestinal disturbances such as nausea or constipation. Patients may also experience a slight risk of dehydration and should be advised to maintain adequate fluid intake.\n\nConclusion\nGLIDAPA TENE 10/20 is an innovative medication for managing Type 2 diabetes, providing potent dual-action control over high blood sugar levels. It simplifies the treatment regimen by combining two effective medications into a single daily dose, potentially enhancing patient compliance and improving overall diabetes management. As always, patients should consult their healthcare provider for personalized advice and to adjust the treatment plan as needed to achieve optimal health outcomes.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order Now\nhttps://www.sterisonline.com/product/glidapa-tene-10-20-134223",
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"description": "GLIMITERIS MV1 0.2 is an advanced fixed-dose combination (FDC) medication designed for adults with Type 2 Diabetes Mellitus (T2DM) who require more than lifestyle modifications or single/dual therapy to maintain optimal blood sugar levels. This innovative formulation brings together the power of three well-established antidiabetic agents—Glimepiride (1 mg), Voglibose (0.2 mg), and Metformin Hydrochloride SR (500 mg)—to provide comprehensive glycemic control.\n\nIt is particularly effective for patients struggling with postprandial hyperglycemia, fasting glucose regulation, and HbA1c reduction, making it a preferred choice in cases of poorly controlled diabetes.\n\n \n\nMechanism of Action\nThe therapeutic benefit of GLIMITERIS MV1 0.2 comes from the unique synergy of its three components, each targeting different aspects of glucose metabolism:\n\n1. Glimepiride (1 mg) – Sulfonylurea\nStimulates insulin secretion by activating pancreatic beta cells.\n\nProvides a long-lasting effect with comparatively lower hypoglycemia risk than older sulfonylureas.\n\nHelps reduce both fasting and postprandial glucose levels.\n\n2. Voglibose (0.2 mg) – Alpha-Glucosidase Inhibitor\nDelays the breakdown and absorption of carbohydrates in the intestine.\n\nMinimizes post-meal glucose spikes (PPBG).\n\nActs locally in the gut and has minimal systemic absorption, which reduces systemic side effects.\n\n3. Metformin Hydrochloride SR (500 mg) – Biguanide\nDecreases hepatic glucose production (gluconeogenesis).\n\nImproves peripheral insulin sensitivity, enhancing glucose uptake in muscles.\n\nDoes not cause hypoglycemia on its own.\n\nThe sustained-release (SR) formulation ensures extended control and reduces gastrointestinal side effects.\n\n \n\nIndications\nGLIMITERIS MV1 0.2 is indicated for:\n\nAdults with Type 2 Diabetes Mellitus.\n\nPatients inadequately controlled with monotherapy or dual therapy.\n\nManagement of fasting and postprandial hyperglycemia.\n\nLong-term HbA1c reduction as part of a comprehensive diabetes care plan.\n\n \n\nKey Benefits\n✅ Comprehensive Blood Sugar Control – Acts on fasting, post-meal, and long-term HbA1c levels.\n✅ Postprandial Spike Management – Voglibose effectively controls carbohydrate-induced sugar surges.\n✅ Reduced Pill Burden – Combines three medicines into a single tablet.\n✅ Lower Hypoglycemia Risk – Metformin and Voglibose balance out Glimepiride’s insulin-secreting effect.\n✅ Weight Management Support – Metformin may promote modest weight loss or prevent weight gain.\n✅ Improved Tolerability – SR formulation of Metformin enhances gastrointestinal comfort.\n\n \n\nDosage and Administration\nRecommended dose: One tablet once or twice daily with meals, or as directed by the physician.\n\nAdministration tips:\n\nTake with the first bite of a main meal to maximize Voglibose’s effect.\n\nSwallow whole with water; do not crush or chew the SR tablet.\n\nDose adjustments: Based on blood sugar monitoring, clinical response, and renal/hepatic function.\n\n \n\nContraindications\nGLIMITERIS MV1 0.2 is not suitable for patients with:\n\nType 1 diabetes or diabetic ketoacidosis.\n\nSevere renal impairment (eGFR <30 mL/min/1.73 m²).\n\nHepatic dysfunction.\n\nSevere gastrointestinal diseases.\n\nHistory of lactic acidosis.\n\nHypersensitivity to Glimepiride, Voglibose, or Metformin.\n\nPregnancy and lactation (unless strictly advised by a physician).\n\n \n\nWarnings and Precautions\nHypoglycemia: Risk is higher when combined with other antidiabetics or with missed meals.\n\nLactic Acidosis: A rare but life-threatening effect of Metformin—renal function monitoring is essential.\n\nGI Side Effects: Voglibose and Metformin may cause bloating, flatulence, or diarrhea (usually temporary).\n\nVitamin B12 Monitoring: Long-term Metformin use may reduce B12 absorption.\n\nLiver and Kidney Function: Regular monitoring is recommended for safe long-term use.\n\n \n\nAdverse Effects\nCommon:\nGlimepiride: Mild hypoglycemia, dizziness, slight weight gain.\n\nVoglibose: Gas, abdominal discomfort, mild diarrhea.\n\nMetformin SR: Nausea, bloating, metallic taste, loose stools.\n\nRare but Serious:\nLactic acidosis (from Metformin).\n\nSevere hypoglycemia (especially if meals are skipped).\n\nAllergic reactions such as rash, itching, or swelling.\n\nElevated liver enzymes.\n\nSeek medical attention if symptoms such as rapid breathing, confusion, severe fatigue, or muscle pain occur.\n\n \n\nDrug Interactions\nIncreased hypoglycemia risk: With insulin, beta-blockers, and sulfonylureas.\n\nReduced Metformin efficacy: With corticosteroids, estrogens, and diuretics.\n\nLactic acidosis risk: Higher with alcohol or iodinated contrast agents. ",
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