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"description": "TENELIGOLD PIO 20/15 \nTeneligliptin & Pioglitazone\nIntroduction\nTENELIGOLD PIO 20/15 combines two antidiabetic medications, Teneligliptin and Pioglitazone, in a single formulation. This combination is designed to manage type 2 diabetes mellitus by targeting different aspects of glucose metabolism, thereby improving glycemic control in patients who are inadequately controlled with monotherapy or require dual therapy.\n\nComposition\n\nTeneligliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucagon release, thereby lowering blood glucose levels.\nPioglitazone: A thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues (muscle and adipose tissue) and reduces hepatic glucose production.\nMechanism of Action\n\nTeneligliptin: Inhibits the degradation of incretin hormones (GLP-1 and GIP), which play a key role in glucose-dependent insulin secretion and suppression of glucagon secretion.\nPioglitazone: Activates peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to improved insulin sensitivity, enhanced glucose uptake in peripheral tissues, and reduced hepatic glucose production.\nIndications\nTENELIGOLD PIO 20/15 is indicated for:\n\nType 2 Diabetes Mellitus: Used to improve glycemic control in adults who are inadequately controlled with diet and exercise alone or with other antidiabetic medications.\nDosage and Administration\n\nThe typical dosage is one tablet of TENELIGOLD PIO 20/15 taken orally once daily, preferably with meals.\nDosage adjustments may be necessary based on individual patient response and tolerability.\nIt is important to adhere to the prescribed dosage regimen to achieve optimal glycemic control.\nSide Effects\nCommon side effects may include:\n\nHypoglycemia (especially when used in combination with insulin or sulfonylureas)\nEdema (fluid retention)\nWeight gain\nHeadache\nNasopharyngitis (common cold)\nMore severe side effects can include:\n\nHeart failure (especially in patients with pre-existing cardiovascular disease)\nHepatic dysfunction (monitor liver function tests periodically)\nBone fractures (especially in women)\nPrecautions\n\nHeart Failure: Use with caution in patients with a history of heart failure or other cardiovascular diseases.\nBladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; therefore, it should be used cautiously in patients with a history of bladder cancer or with risk factors.\nLiver Function: Monitor liver function tests before starting treatment and periodically thereafter, as Pioglitazone may cause hepatic dysfunction.\nPregnancy and Lactation: Use during pregnancy and lactation should be avoided unless the potential benefits outweigh the risks.\nDrug Interactions\n\nInsulin/Sulfonylureas: Increased risk of hypoglycemia when used concomitantly with insulin or sulfonylureas.\nGemfibrozil: May increase Pioglitazone levels, requiring dose adjustment.\nCYP2C8 Inhibitors (e.g., Gemfibrozil): May increase Pioglitazone concentrations, necessitating monitoring for adverse effects.\nConclusion\nTENELIGOLD PIO 20/15 offers a dual-action approach to managing type 2 diabetes mellitus by combining Teneligliptin and Pioglitazone. This combination helps improve glycemic control through different mechanisms: enhancing insulin secretion and sensitivity. It is crucial to use this medication under the guidance of a healthcare professional to optimize treatment outcomes while minimizing the risk of side effects. Regular monitoring for efficacy and safety parameters, including blood glucose levels and potential adverse effects, is essential for managing diabetes effectively with TENELIGOLD PIO 20/15.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n\n",
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"description": "LACOSMILE 200 \nLacosamide 200 mg\nIntroduction:\n\nLACOSMILE 200 contains Lacosamide (200 mg), an antiepileptic medication used to treat partial-onset seizures in patients with epilepsy. Lacosamide helps stabilize electrical activity in the brain, reducing the frequency and severity of seizures and improving the overall quality of life for individuals with epilepsy.\nKey Features and Benefits:\n\nSeizure Control: Lacosamide is effective in controlling partial-onset seizures, helping patients achieve better management of their condition.\nNeurostabilization: It works by selectively enhancing the slow inactivation of voltage-gated sodium channels, which stabilizes hyperexcitable neuronal membranes and prevents seizure activity.\nAdjunctive Therapy: Lacosamide can be used as an adjunctive therapy in combination with other antiepileptic drugs (AEDs), providing additional seizure control for patients who do not achieve full control with a single medication.\nImproved Quality of Life: By reducing the occurrence of seizures, Lacosamide helps improve the overall quality of life for individuals with epilepsy, allowing them to engage more fully in daily activities and reducing the impact of the disorder on their lives.\nDosage and Administration:\n\nInitial Dosage: The typical starting dose of LACOSMILE 200 (Lacosamide 200 mg) is 50 mg to 100 mg taken twice daily. The dosage may be gradually increased based on the patient's response to treatment and tolerability.\nMaintenance Dosage: The usual maintenance dose is 200 mg to 400 mg per day, divided into two doses. The exact dosage should be determined by a healthcare provider.\nAdministration: The tablet should be taken orally with water, with or without food. It is important to take Lacosamide at the same times each day to maintain consistent medication levels in the bloodstream.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\nhttps://www.sterisonline.com/product/lacosmile-200-134206",
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"description": "LACOSMILE 150 \nLacosamide 150 mg\nIntroduction:\n\nLACOSMILE 150 contains Lacosamide (150 mg), an antiepileptic medication used to treat partial-onset seizures in patients with epilepsy. Lacosamide helps stabilize electrical activity in the brain, reducing the frequency and severity of seizures and improving the overall quality of life for individuals with epilepsy.\nKey Features and Benefits:\n\nSeizure Control: Lacosamide is effective in controlling partial-onset seizures, helping patients achieve better management of their condition.\nNeurostabilization: It works by selectively enhancing the slow inactivation of voltage-gated sodium channels, which stabilizes hyperexcitable neuronal membranes and prevents seizure activity.\nAdjunctive Therapy: Lacosamide can be used as an adjunctive therapy in combination with other antiepileptic drugs (AEDs), providing additional seizure control for patients who do not achieve full control with a single medication.\nImproved Quality of Life: By reducing the occurrence of seizures, Lacosamide helps improve the overall quality of life for individuals with epilepsy, allowing them to engage more fully in daily activities and reducing the impact of the disorder on their lives.\nDosage and Administration:\n\nInitial Dosage: The typical starting dose of LACOSMILE 150 (Lacosamide 150 mg) is 50 mg to 100 mg taken twice daily. The dosage may be gradually increased based on the patient's response to treatment and tolerability.\nMaintenance Dosage: The usual maintenance dose is 200 mg to 400 mg per day, divided into two doses. The exact dosage should be determined by a healthcare provider.\nAdministration: The tablet should be taken orally with water, with or without food. It is important to take Lacosamide at the same times each day to maintain consistent medication levels in the bloodstream.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\nhttps://www.sterisonline.com/product/lacosmile-150-134207",
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