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{ "products": [ { "_id": "6abe4471401ae1a1106d67d9", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Bisoprolol 1.25mg", "description": "Bisoprolol 1.25mg is the smallest tablet strength of bisoprolol, a heart-selective beta-1 blocker. Doctors usually prescribe it to start treatment or to build up the dose gradually in people with high blood pressure, chronic stable heart failure, or fast heart rhythms. It suits older adults, people with mild heart failure, and anyone who reacts strongly to beta-blockers. The medicine slows the heartbeat and eases the force of each contraction, so the heart works less hard. BISOGARD 1.25 from Steris Healthcare Pvt. Ltd. comes in a strip pack of 15 tablets. It is a Schedule H medicine, so it must only be started, changed, or stopped on a doctor's advice.\n\nProduct Snapshot\n\nBrand: BISOGARD 1.25\nManufacturer/Marketer: Steris Healthcare Pvt. Ltd., a WHO-GMP and ISO-certified pharmaceutical company in India\nActive ingredient: Bisoprolol Fumarate 1.25mg\nForm: Tablet\nPack size: 15 tablets\nDrug class: Cardioselective beta-1 blocker\nLegal status: Schedule H (valid prescription required)\nAvailability: Through Steris Healthcare's authorized pharmacies and its B2B PCD franchise network across India\nWhat Is Bisoprolol 1.25mg?\n\nIf your doctor has just prescribed bisoprolol 1.25mg, you have been given the lowest dose on purpose. Bisoprolol is a cardioselective beta-1 blocker, meaning it acts mostly on receptors in the heart and has much less effect on the lungs and blood vessels. This is a major reason it is preferred over older, non-selective beta-blockers, especially for people who also have a mild breathing problem.\n\nThe 1.25mg tablet is not a “light” medicine for mild illness. It is a carefully chosen entry point. In heart failure, a weakened heart can struggle if its rate or pressure drops too quickly, so cardiologists follow a “start low, go slow” approach. Treatment begins at 1.25mg, the response is watched for one to two weeks, and the dose is raised step by step (commonly 2.5mg, 3.75mg, 5mg, 7.5mg, and up to 10mg) as the heart adapts. That is why BISOGARD 1.25 is often the first tablet a newly diagnosed heart failure patient takes.\n\nWhat Is Bisoprolol 1.25mg Used For?\n\nDoctors commonly prescribe this strength for:\n\nChronic heart failure (HFrEF): as the first step of dose titration in patients with a reduced ejection fraction, alongside ACE inhibitors/ARBs and diuretics\nHigh blood pressure: especially in older adults, people with low body weight, and those who are sensitive to blood-pressure-lowering drugs\nStable angina: to reduce the heart's oxygen demand and relieve chest discomfort\nAfter a heart attack: in selected patients, under a cardiologist's care\nHeart rate control in some arrhythmias: sometimes used off-label at a low dose to gently bring down a fast heart rate\n\nAt 1.25mg, bisoprolol is seldom meant as the long-term sole treatment for high blood pressure in an otherwise healthy adult. It is usually the first rung of a titration ladder, or a steady maintenance dose for patients who are unusually beta-blocker sensitive (older age, low body weight, or borderline low pressure or pulse).\n\nHow Does Bisoprolol Work?\n\nBisoprolol selectively blocks beta-1 adrenergic receptors, which are packed mainly into heart muscle. This leads to several effects:\n\nSlower heart rate: the heart has more time to fill and rest between beats\nGentler contractions: the heart muscle needs less oxygen and energy\nLess renin from the kidneys: this helps blood pressure fall gradually over time\nLower overall cardiac workload: a real advantage for a heart that already struggles to pump well, as in heart failure\nKey Benefits of BISOGARD 1.25\nA gentle starting dose, well suited to careful titration in frail or elderly patients\nHeart-focused action, with less effect on the lungs and peripheral blood vessels than non-selective beta-blockers\nOnce-daily dosing, which makes it easier to stay on treatment\nA guideline-recommended beta-blocker for HFrEF with well-established outcomes data [Reviewer note: insert specific outcome statistics/trial citation pending medical sign-off]\nMade by Steris Healthcare Pvt. Ltd. under WHO-GMP and ISO-certified standards\nDosage Guidance\nUsual starting dose (heart failure): 1.25mg once a day, preferably in the morning\nDose increases: typically every 1–2 weeks (2.5mg, 3.75mg, 5mg, 7.5mg, up to a maximum of 10mg daily), depending on how well you tolerate it and on your pulse and blood pressure\nHigh blood pressure (sensitive patients): 1.25mg to 5mg once daily, as set by your doctor\nHow to take it: at the same time every day, with or without food, swallowed whole with water\nIf you miss a dose: take it when you remember, unless the next dose is almost due. Never take a double dose.\nNever stop suddenly: abrupt withdrawal can cause a rebound rise in heart rate, blood pressure, or chest pain. The dose must be reduced gradually under medical supervision.\nIs It Better to Take Bisoprolol in the Morning or at Night?\n\nMost doctors advise a morning dose. Bisoprolol lowers pulse and blood pressure, and taking it early matches its action to your daytime activity. A night-time dose could add to the body's natural overnight dip in blood pressure and raise the chance of dizziness when getting up in the dark. Some people who feel tired during the day are told by their doctor to switch to the evening. Do not change your dosing time without your doctor's approval.\n\nSide Effects of Bisoprolol 1.25mg\n\nCommon side effects\n\nTiredness or fatigue\nDizziness or light-headedness, especially on standing quickly\nCold hands or feet\nSlow pulse (bradycardia)\nHeadache\nMild stomach upset (nausea, loose stools)\nDisturbed sleep\n\nSerious side effects (get medical help promptly)\n\nVery slow heartbeat or fainting\nIncreasing breathlessness or swollen legs/ankles, which may mean heart failure is worsening\nAllergic reaction: rash, swelling of the face or throat, trouble breathing\nCold, numb, or bluish fingers and toes\nWheezing or new breathing difficulty, particularly in people with asthma or COPD\nMood changes, low mood, or confusion\nWhat Are the Bad Side Effects of Bisoprolol?\n\nThe effects that need urgent attention are a dangerously slow pulse, fainting, signs of worsening heart failure (swelling, breathlessness), severe allergic reactions, and airway tightening in people with lung disease. These are uncommon at the 1.25mg dose, but anyone who notices them should seek medical help right away. [Reviewer note: specific incidence rates pending clinical/medical sign-off]\n\nSubstitutes & Comparable Beta-Blockers\nMolecule\tSelectivity\tTypical Use Case\nBisoprolol\tHighly cardioselective\tHeart failure titration, hypertension\nMetoprolol Succinate ER\tCardioselective\tHypertension, angina, heart failure\nAtenolol\tCardioselective (older agent)\tHypertension\nCarvedilol\tNon-selective with alpha-blocking action\tHeart failure (adds vasodilation)\nPropranolol\tNon-selective\tMigraine prevention, anxiety-related fast heartbeat, essential tremor\nPrecautions & Who Should Avoid Bisoprolol\nNot suitable for people with severe bradycardia, certain forms of heart block (unless a pacemaker is fitted), unstable or acutely decompensated heart failure, or severe uncontrolled asthma\nUse carefully in diabetes, because beta-blockers can hide the warning signs of low blood sugar\nTake care in peripheral vascular disease, as cold extremities or leg pain on walking may worsen\nNever stop it abruptly; always taper under a doctor's guidance\nTell your doctor about every medicine you use, especially other blood-pressure drugs, calcium channel blockers, and certain antiarrhythmics\nIn pregnancy and breastfeeding, use only if your doctor advises it after weighing benefits and risks\nIs Bisoprolol Safe for Kidneys?\n\nThe body clears bisoprolol through both the liver and the kidneys in roughly equal measure. It is generally considered safe for people with normal or mildly reduced kidney function. When kidney impairment is significant, drug levels in the blood can rise, so your doctor may lower the dose or monitor you more closely. Always tell your prescriber about any kidney disease before starting.\n\nIs Bisoprolol a High-Risk Medication?\n\nBisoprolol is not a narrow therapeutic index drug like tacrolimus or warfarin, where small dose differences matter greatly. Even so, it needs supervised use because it directly affects heart rate and blood pressure. The main dangers are stopping it suddenly, which can set off rebound cardiac events, and using it with certain existing rhythm disorders. Taken as prescribed and checked regularly, it has a long and reassuring safety record.\n\nDoes 1.25mg Bisoprolol Lower Blood Pressure?\n\nYes. Even the smallest dose measurably reduces heart rate and blood pressure by lightening the heart's workload and reducing renin-driven narrowing of blood vessels. At this strength the effect on blood pressure is fairly mild, which is exactly why it is a safe place to begin, especially for older adults or people starting heart failure treatment. The dose is then raised gradually to reach full benefit.\n\nFrequently Asked Questions\n\n1. What is 1.25 mg of bisoprolol used for?\nMainly as a low starting dose when building up treatment for chronic heart failure, and for high blood pressure in people who are very sensitive to beta-blockers, such as older adults.\n\n2. What are the bad side effects of bisoprolol?\nThe more serious ones are a very slow pulse, fainting, worsening heart failure signs (swelling, breathlessness), severe allergy, and breathing trouble in people with lung conditions.\n\n3. What are the common side effects of bisoprolol fumarate 1.25 mg tablets?\nTiredness, dizziness, cold hands and feet, mild headache, and a slightly slower pulse.\n\n4. Is it better to take bisoprolol in the morning or at night?\nMorning is usually preferred so its effect fits daytime activity, though your doctor may suggest evenings in some cases.\n\n5. What is the cost of bisoprolol?\nPrice depends on strength, pack size, and brand. Use the “Check Price” option above for current BISOGARD 1.25 pricing from Steris Healthcare.\n\n6. Does 1.25 mg bisoprolol lower blood pressure?\nYes, though only modestly at this dose. The dose is often stepped up over time.\n\n7. Is bisoprolol safe for kidneys?\nGenerally yes for normal or mildly reduced kidney function. People with significant kidney impairment need dose adjustment and monitoring.\n\n8. Is bisoprolol a high-risk medication?\nIt is not a narrow therapeutic index drug, but it must never be stopped suddenly and should be used under medical supervision because of its direct effect on the heart.\n\n9. Can I take bisoprolol 1.25mg for the rest of my life?\nMany people with chronic heart failure or hypertension do take bisoprolol long term, but the dose usually rises as tolerated. Your doctor should review it regularly.\n\n10. What happens if I miss a dose of bisoprolol?\nTake it when you remember, unless the next dose is nearly due. In that case skip the missed one. Never take two together.\n\n11. Can bisoprolol 1.25mg cause weight gain?\nIt is not commonly reported at this dose. Fluid retention linked to heart failure itself should be reported to your doctor.\n\n12. Is bisoprolol safe for diabetic patients?\nIt can be used, with care, because beta-blockers may hide warning signs of low blood sugar such as a racing heartbeat.\n\n13. Can I stop taking bisoprolol suddenly if I feel fine?\nNo. Stopping abruptly can cause a rebound rise in heart rate, blood pressure, or chest pain. Reduce the dose gradually under medical guidance.\n\n14. Does bisoprolol interact with other blood pressure medicines?\nYes. Combining it with other drugs that lower heart rate or pressure (such as calcium channel blockers) can cause a very low pulse or pressure. Tell your doctor about all your medicines.\n\n15. Is BISOGARD 1.25 available without a prescription?\nNo. Bisoprolol is a Schedule H medicine in India and needs a valid prescription.\n\n16. How long does it take for bisoprolol 1.25mg to start working?\nSome effect on heart rate appears within hours, but the full benefit for blood pressure or heart failure symptoms builds over several weeks of regular use.\n\n17. Can pregnant women take bisoprolol?\nOnly if clearly necessary and prescribed by a doctor, as it may affect the baby's heart rate and growth.", "price": 39.0, "discountamount": 12.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2501, "imageuri": "https://productimages.withfloats.com/actual/6abe4474c205678e0b16a23a.png", "tileimageuri": "https://productimages.withfloats.com/tile/6abe4474c205678e0b16a23a.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-10-01T11:30:57.88Z", "updatedon": "2026-10-01T11:30:57.88Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/bisoprolol-1-25mg/2501", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "Bisogard 1.25", "category": "CARDIOLOGYRANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a86e496cc4491de1ed77dfd", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Etoricoxib & Cyclobenzaprine Hydrochloride Tablets", "description": "ERITOCOX BENZ 90/5 is a fixed-dose combination tablet pairing Etoricoxib 90 mg, a selective COX-2 anti-inflammatory, with Cyclobenzaprine Hydrochloride 5 mg, a centrally acting muscle relaxant. It is prescribed for short-term relief of acute musculoskeletal problems where pain, swelling, and muscle tightness occur together — think a sudden low-back strain, a stiff neck, or a flare-up of arthritis where the surrounding muscles clamp down defensively. Rather than treating the inflammation alone or the spasm alone, this tablet addresses both mechanisms in one dose, which can mean fewer pills and a more complete response for short, acute episodes. It is a prescription-only (Schedule H) medicine, produced under WHO-GMP and ISO-certified manufacturing standards by Steris Healthcare Pvt. Ltd. Typical side effects include drowsiness, dry mouth, and mild stomach upset; because the combination carries cardiovascular, gastrointestinal, and kidney considerations, it should only be used under a doctor's supervision. This page walks through what the tablet does, how it works, correct usage, safety information, and answers to the questions people most often ask.\n\nWhat Is ERITOCOX BENZ 90/5?\n\nPain from an acute back injury, a wrenched neck, or an arthritis episode almost never travels alone — it tends to bring a tense, guarded muscle along with it that makes every movement feel worse. ERITOCOX BENZ 90/5 was formulated with that pattern in mind, folding two separate mechanisms into a single tablet rather than requiring two prescriptions.\n\nActive Ingredient\tStrength\tRole\nEtoricoxib\t90 mg\tSelective COX-2 inhibitor for inflammatory pain\nCyclobenzaprine Hydrochloride\t5 mg\tCentrally acting skeletal muscle relaxant\n\nEach tablet is manufactured by Steris Healthcare Pvt. Ltd., a WHO-GMP and ISO-certified pharmaceutical company, so every batch meets verified potency and quality benchmarks.\n\nWhy This Combination Makes Sense\n\nMusculoskeletal pain is rarely a single-track problem. When tissue is injured or irritated, inflammation flares up locally — and nearby muscles frequently respond by tightening protectively. That protective tightening, the spasm, often becomes a pain generator of its own. Treat only the inflammation and the spasm can linger; treat only the spasm and the underlying inflammation keeps driving discomfort.\n\nERITOCOX BENZ 90/5 is built to intervene on both fronts at once:\n\nEtoricoxib addresses the chemical cascade responsible for pain and swelling at the injured site.\nCyclobenzaprine works through the central nervous system to calm the muscle guarding that so often rides alongside that pain.\nMechanism of Action: How ERITOCOX BENZ 90/5 Works\n\nEtoricoxib selectively inhibits the COX-2 enzyme — the enzyme the body ramps up at sites of tissue damage or irritation to manufacture prostaglandins, the chemical messengers behind pain, swelling, and localized heat. Because it targets COX-2 specifically rather than blocking both COX-1 and COX-2 the way older, non-selective NSAIDs do, etoricoxib is designed to control inflammatory pain while leaving more of the COX-1 activity that protects the stomach lining relatively undisturbed.\n\nCyclobenzaprine Hydrochloride takes a different route entirely — its primary site of action is the brainstem, not the muscle fiber itself. By dampening excessive motor signaling sent to skeletal muscle, it reduces spasm and stiffness without producing the broad muscle weakness that a directly-acting muscle agent might cause.\n\nPut together, the tablet delivers a two-pronged effect: peripheral anti-inflammatory action from etoricoxib, layered with central muscle relaxation from cyclobenzaprine.\n\n[Reviewer placeholder: insert verified pharmacokinetic data (onset, half-life, bioavailability) once confirmed by medical/regulatory team — do not publish unverified figures.]\n\nClinical Uses of ERITOCOX BENZ 90/5\n\nA physician may prescribe this combination for short-term management of acute conditions where pain, inflammation, and spasm show up together, including:\n\nCondition\tTypical Presentation\nAcute lower back pain\tPain with associated muscle guarding/spasm\nNeck strain / cervical spasm\tStiff, restricted neck movement\nSprains, strains, overuse injuries\tMusculoskeletal trauma with inflammatory pain\nOsteoarthritis flare-ups\tJoint pain accompanied by surrounding muscle tightness\nPostural or occupational muscle pain\tWork- or posture-related inflammation and tension\nMovement restriction linked to spasm\tReduced range of motion driven by muscular guarding\n\nSuitability for any of the above must be confirmed by a doctor based on your specific diagnosis and medical history.\n\nKey Benefits of ERITOCOX BENZ 90/5\nOne tablet, two mechanisms — anti-inflammatory pain relief and muscle-spasm relief combined, simplifying an otherwise two-drug regimen.\nSite-focused inflammation control — etoricoxib's COX-2 selectivity is intended to concentrate its effect where inflammation is actually active.\nA comparatively gentler GI footprint — COX-2-selective action is generally linked to lower gastrointestinal irritation risk than older non-selective NSAIDs, though vigilance is still warranted.\nLoosens spasm-related stiffness — cyclobenzaprine's central action helps release tight, guarded muscles restricting movement.\nAids functional recovery — easing both pain and spasm can make it more realistic to resume light activity, stretching, or physiotherapy once your doctor clears you.\nStreamlined short-course dosing — a once-daily schedule (as prescribed) cuts down pill burden versus taking an NSAID and a muscle relaxant separately.\nDosage & Administration\n\nThe following is general reference information — your doctor's specific prescription always takes precedence.\n\nTake ERITOCOX BENZ 90/5 exactly as prescribed, generally once a day, with or without food.\nSwallow the tablet whole with water; avoid crushing or chewing unless your doctor tells you otherwise.\nTreatment is typically short — anywhere from a few days to roughly two weeks — reflecting the acute, self-limiting nature of most pain-and-spasm episodes.\nIf a dose is missed, take it as soon as you remember, but skip it entirely if the next dose is nearly due. Never double up to make up for a missed dose.\nDo not extend the treatment period or adjust your dose independently, even if symptoms haven't fully resolved.\nSide Effects of ERITOCOX BENZ 90/5\nCommon Side Effects\nDrowsiness or sleepiness\nDizziness\nDry mouth\nHeadache\nStomach discomfort or indigestion\nNausea\nFatigue\nMild elevation in blood pressure in some individuals\nSerious Side Effects — Seek Medical Help Promptly\nSigns of gastrointestinal bleeding, such as black stools or vomiting blood\nA severe allergic reaction — swelling of the face or throat, breathing difficulty, or widespread rash\nChest pain, irregular heartbeat, or other symptoms suggestive of a cardiovascular event\nYellowing of the skin or eyes, which may point to liver involvement\nA noticeable drop in urine output, which may suggest kidney impairment\nSevere dizziness, confusion, or fainting\n\nIf any of these serious symptoms appear, stop the medicine and get medical attention immediately.\n\nPrecautions & Warnings\nShare your full medical history with your doctor before starting, including any heart, kidney, or liver conditions.\nUse cautiously — or avoid altogether — if you have a history of stomach ulcers or gastrointestinal bleeding.\nGenerally not advised for people with uncontrolled high blood pressure, existing heart disease, or a prior stroke, unless a doctor specifically clears its use.\nSteer clear of alcohol, since it can amplify cyclobenzaprine's sedative effect and add to gastrointestinal risk.\nCyclobenzaprine may cause drowsiness or dizziness — hold off on driving or operating machinery until you know how the tablet affects you.\nDon't combine ERITOCOX BENZ 90/5 with other NSAIDs, painkillers, or sedating medicines without checking with your doctor first.\nAvoid the medicine if you have known hypersensitivity to etoricoxib, cyclobenzaprine, or related compounds.\nNot generally recommended during pregnancy or breastfeeding unless a doctor specifically advises otherwise.\nAvoid combining with MAO inhibitors, or using shortly after stopping them.\nDrug Interactions to Flag With Your Doctor\n\nDisclose every prescription medicine, over-the-counter product, and supplement you take. Extra caution is needed around medicines affecting:\n\nBlood pressure regulation\nKidney function\nBlood clotting\nCentral nervous system activity (sedatives, other muscle relaxants)\nLiver metabolism\nOther anti-inflammatory or pain-relief medicines\nConclusion\n\nERITOCOX BENZ 90/5 brings Etoricoxib 90 mg and Cyclobenzaprine Hydrochloride 5 mg together to tackle a problem that rarely presents as a single issue — pain, inflammation, and muscle spasm that reinforce one another in acute musculoskeletal conditions. By acting on both the inflammatory and muscular sides of that cycle, it offers a more rounded short-term response than either ingredient could provide alone.\n\nGiven the genuine cardiovascular, gastrointestinal, kidney, and central-nervous-system considerations involved, ERITOCOX BENZ 90/5 is meant strictly for short, doctor-supervised courses — not casual or extended self-treatment. Always check with your doctor to confirm whether this combination is right for your condition, medical history, and current medications.\n\nPrescription only – consult your doctor.\n\nFrequently Asked Questions (Google & AI Mode / Voice Search Optimized)\n\n1. What is ERITOCOX BENZ 90/5 used for? It's typically prescribed for short-term relief of acute musculoskeletal issues — such as back pain, neck strain, or an arthritis flare-up — where pain, inflammation, and muscle spasm show up together.\n\n2. Is ERITOCOX BENZ 90/5 a muscle relaxant? It's a combination tablet: the muscle-relaxing effect comes from its Cyclobenzaprine Hydrochloride component, while Etoricoxib supplies the pain-relieving, anti-inflammatory action.\n\n3. Is Etoricoxib a strong painkiller? Etoricoxib is an effective selective COX-2 inhibitor typically used for moderate inflammation-related pain, such as arthritis or an acute musculoskeletal injury. Its appropriateness for your level of pain should be assessed by a doctor.\n\n4. Is Etoricoxib safe for the kidneys? As with other NSAIDs, etoricoxib can influence kidney function, particularly with extended use, higher doses, dehydration, or existing kidney disease. It should be used carefully and only under medical guidance if kidney health is a concern.\n\n5. Should ERITOCOX BENZ 90/5 be taken in the morning or at night? It's usually taken once a day at a time your doctor sets. Since cyclobenzaprine can cause drowsiness, many doctors lean toward an evening dose — but always stick to your specific prescription.\n\n6. What are the common side effects of ERITOCOX BENZ 90/5? Frequently reported effects include drowsiness, dizziness, dry mouth, headache, stomach discomfort, and mild fatigue. Most fade on their own, but persistent symptoms should be reported to your doctor.\n\n7. How fast does ERITOCOX BENZ 90/5 start working? Etoricoxib tends to absorb fairly quickly, and many people feel pain relief within roughly an hour, though onset can vary by individual and whether the tablet is taken with food.\n\n8. What should be avoided while on ERITOCOX BENZ 90/5? Skip alcohol, avoid taking other NSAIDs or painkillers without medical advice, and hold off on driving or operating machinery if you're feeling drowsy or dizzy.\n\n9. How many days can ERITOCOX BENZ 90/5 be taken? It's usually prescribed for a short stretch — a few days up to around two weeks — matching how acute conditions typically resolve. Anything longer needs your doctor's review.\n\n10. What are the benefits of ERITOCOX BENZ 90/5? It delivers combined relief from pain, inflammation, and muscle spasm in one tablet, which can make it easier to move normally and get back to daily activity sooner when used as directed.\n\n11. How safe is ERITOCOX BENZ 90/5? Taken exactly as prescribed and for the recommended duration, it's generally considered safe for most adults. It does carry cardiovascular, gastrointestinal, kidney, and liver-related risks that call for medical supervision, especially if you already have related conditions.\n\n12. Can ERITOCOX BENZ 90/5 be used for knee pain? Yes — its etoricoxib component is commonly used for joint pain tied to osteoarthritis or an acute injury, including the knee, by reducing the underlying inflammation. A doctor should confirm suitability first.\n\n13. Does ERITOCOX BENZ 90/5 cause drowsiness? Yes — drowsiness and dizziness are known effects linked to its cyclobenzaprine component. Avoid driving or tasks requiring full alertness until you know how it affects you.\n\n14. Can ERITOCOX BENZ 90/5 be bought without a prescription? No. This is a prescription-only medicine meant to be taken solely under a qualified doctor's supervision — it isn't meant for self-prescribing or extended use without medical oversight.\n\n15. Can ERITOCOX BENZ 90/5 be taken with food? It can generally be taken with or without food, though taking it with food may ease stomach discomfort for some people. Follow your doctor's specific instructions.\n\n16. Is ERITOCOX BENZ 90/5 habit-forming? Cyclobenzaprine isn't considered addictive with typical short-term use, but the tablet should still be taken only for the prescribed duration and not restarted on your own without medical advice.\n\n17. Who should avoid taking ERITOCOX BENZ 90/5? People with active stomach ulcers, significant heart, kidney, or liver disease, known hypersensitivity to NSAIDs, or those who are pregnant or breastfeeding should avoid it unless a doctor specifically clears its use.", "price": 222.0, "discountamount": 67.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2495, "imageuri": "https://productimages.withfloats.com/actual/6a86e4990f089c4695c57658.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a86e4990f089c4695c57658.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-08-20T11:27:18.403Z", "updatedon": "2026-08-20T11:27:18.403Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//etoricoxib-cyclobenzaprine-hydrochloride-tablets/2495", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "ERITOCOX BENZ 90/5", "category": "", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a6def248b0777b5cb29791c", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Propranolol Hydrochloride Sustained Release Capsules IP", "description": "PROPASULES LA 40 is a premium pharmaceutical formulation containing Propranolol Hydrochloride Sustained Release Capsules IP 40 mg. Developed with advanced sustained-release technology, this formulation delivers the active ingredient gradually over an extended period, helping maintain consistent therapeutic levels while supporting the convenience of once-daily administration when prescribed by a healthcare professional.\n\nManufactured in GMP-certified facilities using pharmaceutical-grade raw materials, PROPASULES LA 40 is produced under strict quality control measures to ensure purity, safety, and batch-to-batch consistency. It is intended for the treatment of medical conditions in which propranolol therapy is considered appropriate by a qualified physician.\n\nComposition\n\nEach Sustained Release Capsule Contains:\n\nPropranolol Hydrochloride IP – 40 mg\nSustained Release Pellets\nPharmaceutical Excipients – q.s.\nCapsule Shell – Approved pharmaceutical-grade ingredients\n\nDosage Form: Sustained Release Capsules\n\nWhat is PROPASULES LA 40?\n\nPROPASULES LA 40 contains Propranolol Hydrochloride, a non-selective beta-adrenergic receptor blocker (beta-blocker) that helps manage a variety of cardiovascular and neurological conditions. The sustained-release formulation is specifically designed to release the medicine gradually throughout the day, providing prolonged therapeutic action and helping maintain stable plasma drug concentrations compared with conventional immediate-release formulations.\n\nIts controlled-release technology enhances dosing convenience and supports consistent treatment outcomes when used according to medical advice.\n\nKey Features\nContains Propranolol Hydrochloride Sustained Release IP 40 mg\nAdvanced sustained-release technology for prolonged drug delivery\nSupports once-daily dosing as prescribed\nManufactured using premium pharmaceutical-grade ingredients\nProduced in GMP-compliant manufacturing facilities\nStringent quality assurance for consistent product performance\nReliable formulation for long-term therapeutic use under medical supervision\nTherapeutic Uses\n\nHealthcare professionals may prescribe PROPASULES LA 40 for the management of several cardiovascular and neurological disorders, including:\n\nHypertension (high blood pressure)\nChronic stable angina\nCardiac arrhythmias\nPrevention of migraine attacks\nEssential tremor\nPhysical symptoms associated with anxiety\nCardiovascular manifestations of hyperthyroidism\nSecondary prevention following myocardial infarction, when clinically indicated\n\nThe choice of treatment, dosage, and duration should always be individualized based on the patient's medical condition and physician's assessment.\n\nHow PROPASULES LA 40 Works\n\nPropranolol Hydrochloride works by blocking beta-adrenergic receptors located in the heart and other tissues. This action reduces the effects of adrenaline and other stress hormones on the cardiovascular system.\n\nAs a result, the medicine may help:\n\nSlow the heart rate\nReduce the workload on the heart\nLower elevated blood pressure\nImprove control of certain abnormal heart rhythms\nReduce the frequency of migraine episodes\nMinimize symptoms associated with essential tremor\nRelieve physical manifestations of anxiety, such as rapid heartbeat and trembling\n\nThe sustained-release pellets gradually release the medication throughout the day, providing prolonged therapeutic coverage and reducing fluctuations in drug levels.\n\nBenefits of the Sustained Release Formulation\n\nThe advanced sustained-release technology offers several advantages:\n\nControlled and gradual release of the active ingredient\nExtended therapeutic effect throughout the dosing interval\nMore consistent blood concentrations of the medication\nReduced peak-to-trough fluctuations compared with immediate-release formulations\nConvenient dosing schedule that may improve treatment adherence\nSuitable for long-term therapy under medical supervision\n\nTreatment outcomes depend on individual patient response and adherence to the prescribed regimen.\n\nDosage and Administration\n\nTake PROPASULES LA 40 exactly as instructed by your healthcare provider.\n\nGeneral recommendations include:\n\nSwallow the capsule whole with sufficient water.\nDo not crush, chew, or open the capsule unless specifically advised.\nTake the medicine at the same time every day.\nFollow the prescribed dosage schedule carefully.\nDo not discontinue treatment abruptly without consulting your physician, as sudden withdrawal may increase the risk of cardiovascular complications.\nPossible Side Effects\n\nLike all medications, PROPASULES LA 40 may cause side effects in some individuals, although many patients tolerate it well.\n\nCommon side effects may include:\n\nFatigue\nDizziness\nSlow heartbeat\nCold hands and feet\nNausea\nSleep disturbances\nMild stomach discomfort\n\nSeek immediate medical attention if you experience breathing difficulty, severe dizziness, fainting, swelling of the face or throat, or signs of a serious allergic reaction.\n\nConsult your healthcare provider if any side effects persist or become troublesome.\n\nPrecautions and Warnings\n\nBefore starting PROPASULES LA 40, inform your doctor if you have:\n\nAsthma or chronic obstructive pulmonary disease (COPD)\nDiabetes mellitus\nLiver impairment\nKidney disease\nHeart failure\nLow blood pressure\nBradycardia (slow heart rate)\nPeripheral vascular disease\nThyroid disorders\nHistory of hypersensitivity reactions\n\nYour physician should also be informed about all prescription medicines, over-the-counter drugs, herbal supplements, and dietary products you are taking to minimize the risk of drug interactions.\n\nPregnancy and Breastfeeding\n\nThe use of PROPASULES LA 40 during pregnancy or breastfeeding should only be considered when recommended by a qualified healthcare professional after carefully evaluating the potential benefits and possible risks.\n\nAlways consult your physician before taking this medicine during pregnancy or while nursing.\n\nStorage Instructions\n\nTo maintain product quality:\n\nStore in a cool and dry place.\nProtect from moisture and direct sunlight.\nKeep below the storage temperature specified on the product label.\nStore in the original packaging until use.\nKeep out of the reach of children.\nDo not use the medicine after the expiry date printed on the pack.\nWhy Choose PROPASULES LA 40?\n\nPROPASULES LA 40 is formulated to deliver dependable therapeutic performance through advanced sustained-release technology. Manufactured under stringent pharmaceutical quality standards, it combines consistent drug delivery, convenient dosing, and reliable product quality to support long-term cardiovascular and neurological care.\n\nKey Advantages\n\nPremium sustained-release Propranolol formulation\nControlled drug release for prolonged therapeutic action\nConvenient once-daily administration as prescribed\nManufactured in GMP-certified facilities\nHigh standards of quality, purity, and consistency\nReliable formulation for chronic disease management\nFrequently Asked Questions (FAQs)\nWhat is PROPASULES LA 40 prescribed for?\n\nPROPASULES LA 40 may be prescribed for conditions such as hypertension, chronic angina, cardiac arrhythmias, migraine prevention, essential tremor, anxiety-related physical symptoms, and certain cardiovascular conditions, depending on the physician's evaluation.\n\nCan PROPASULES LA 40 be taken once a day?\n\nYes. The sustained-release formulation is designed to support convenient once-daily dosing when prescribed by a healthcare professional.\n\nCan I stop taking PROPASULES LA 40 suddenly?\n\nNo. Abrupt discontinuation of propranolol may increase the risk of serious cardiovascular events. Always consult your doctor before stopping treatment.\n\nCan people with diabetes take PROPASULES LA 40?\n\nPatients with diabetes should use this medicine only under medical supervision, as beta-blockers may mask some warning signs of low blood sugar.\n\nIs PROPASULES LA 40 suitable for every patient?\n\nNo. This medicine may not be appropriate for individuals with certain conditions such as severe asthma, significant bradycardia, or specific cardiac disorders. Your healthcare provider will determine whether it is suitable for your individual medical needs.", "price": 45.0, "discountamount": 14.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2490, "imageuri": "https://productimages.withfloats.com/actual/6a6def271f223d84dee2d962.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a6def271f223d84dee2d962.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-08-01T13:05:40.676Z", "updatedon": "2026-08-01T13:05:40.676Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//propranolol-hydrochloride-sustained-release-capsules-ip/2490", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "PROPASULES LA 40", "category": "CARDIOLOGYRANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a6dec4d7747964c2eea9a0f", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Metoprolol Succinate & Hydrochlorthiazide Extended Release Tablets", "description": "METAPROLATE H 50/12.5 is a premium antihypertensive medication formulated with Metoprolol Succinate Extended Release 50 mg and Hydrochlorothiazide 12.5 mg. This dual-action combination is intended for the treatment of hypertension (high blood pressure) in adults who require combination therapy for better blood pressure control. By combining two well-established medicines with complementary mechanisms of action, the formulation helps support long-term cardiovascular health while offering the convenience of once-daily dosing.\n\nManufactured in GMP-certified facilities using high-quality pharmaceutical ingredients, METAPROLATE H 50/12.5 is produced under rigorous quality assurance protocols to ensure safety, efficacy, and batch-to-batch consistency. The extended-release technology allows a gradual release of Metoprolol throughout the day, providing sustained therapeutic effects and helping maintain stable blood pressure levels.\n\nComposition\n\nBrand Name: METAPROLATE H 50/12.5\n\nGeneric Name: Metoprolol Succinate Extended Release & Hydrochlorothiazide Tablets\n\nEach Extended Release Tablet Contains:\n\nMetoprolol Succinate Extended Release – 50 mg\nHydrochlorothiazide – 12.5 mg\n\nDosage Form: Extended Release Tablets\n\nTherapeutic Category: Antihypertensive Medication\n\nWhat is METAPROLATE H 50/12.5?\n\nMETAPROLATE H 50/12.5 combines a beta-blocker and a thiazide diuretic to provide comprehensive blood pressure management.\n\nMetoprolol Succinate selectively blocks beta-1 receptors in the heart, reducing heart rate and decreasing the workload on the cardiovascular system. Hydrochlorothiazide acts as a diuretic by helping the body eliminate excess sodium and water through urine, lowering blood volume and contributing to reduced blood pressure.\n\nTogether, these medicines offer a complementary approach to hypertension treatment and may help lower the risk of complications associated with persistently elevated blood pressure, including stroke, heart attack, and kidney damage, when used according to medical advice.\n\nUses of METAPROLATE H 50/12.5\n\nHealthcare professionals may prescribe METAPROLATE H 50/12.5 for:\n\nManagement of essential hypertension\nPatients requiring combination antihypertensive therapy\nLong-term maintenance of healthy blood pressure levels\nReducing cardiovascular risks associated with uncontrolled hypertension\nSupporting comprehensive blood pressure management alongside lifestyle modifications\n\nThis medicine should always be used under the supervision of a qualified healthcare professional.\n\nBenefits of METAPROLATE H 50/12.5\nDual-Action Blood Pressure Control\n\nThe combination of Metoprolol Succinate and Hydrochlorothiazide addresses hypertension through two different therapeutic pathways, providing effective blood pressure reduction.\n\nSustained Drug Release\n\nThe extended-release formulation delivers Metoprolol gradually over 24 hours, helping maintain stable therapeutic levels and consistent blood pressure control.\n\nConvenient Once-Daily Administration\n\nA single daily dose simplifies long-term treatment and may improve patient adherence to prescribed therapy.\n\nSupports Cardiovascular Health\n\nMaintaining optimal blood pressure with appropriate treatment can help reduce the likelihood of serious cardiovascular complications over time.\n\nManufactured to High Quality Standards\n\nEvery batch is produced using premium pharmaceutical ingredients under strict GMP guidelines, ensuring reliable quality, safety, and consistency.\n\nHow METAPROLATE H 50/12.5 Works\n\nThe effectiveness of METAPROLATE H 50/12.5 is based on the complementary actions of its two active ingredients.\n\nMetoprolol Succinate works by selectively blocking beta-1 adrenergic receptors in the heart, which helps:\n\nSlow the heart rate\nReduce the force of cardiac contractions\nDecrease oxygen demand by the heart\nLower blood pressure\n\nHydrochlorothiazide works by promoting the removal of excess salt and water from the body through the kidneys. This helps:\n\nReduce circulating blood volume\nMinimize fluid retention\nLower blood pressure\nImprove overall cardiovascular function\n\nTogether, these mechanisms contribute to effective and sustained blood pressure management.\n\nDosage and Administration\n\nTake METAPROLATE H 50/12.5 exactly as prescribed by your physician.\n\nGeneral recommendations include:\n\nTake one tablet daily or as directed by your healthcare provider.\nSwallow the extended-release tablet whole with water.\nDo not crush, chew, or split the tablet unless specifically instructed.\nIt may be taken with or without food according to your doctor's advice.\nTake the medication at the same time each day to maintain consistent therapeutic levels.\nContinue treatment as prescribed, even if your blood pressure is well controlled, unless your doctor advises otherwise.\nPossible Side Effects\n\nAs with any prescription medicine, some individuals may experience side effects, although many people tolerate the medication well.\n\nCommonly reported side effects include:\n\nDizziness\nTiredness or fatigue\nSlow heartbeat\nHeadache\nIncreased urination\nNausea\nLow blood pressure\nChanges in electrolyte levels\n\nSeek immediate medical attention if you experience severe allergic reactions, breathing difficulties, fainting, persistent chest pain, or any other serious symptoms.\n\nConsult your healthcare provider if any side effect persists or becomes troublesome.\n\nPrecautions and Warnings\n\nBefore starting METAPROLATE H 50/12.5, inform your healthcare provider if you have:\n\nHeart rhythm abnormalities\nHeart failure\nAsthma or chronic respiratory disorders\nDiabetes mellitus\nKidney or liver impairment\nGout\nElectrolyte imbalance\nThyroid disorders\nAllergy to Metoprolol, Hydrochlorothiazide, sulfonamide-derived medicines, or any ingredient in this product\n\nRegular monitoring of blood pressure, heart rate, kidney function, and electrolyte levels may be recommended during treatment.\n\nStorage Instructions\n\nTo maintain product quality:\n\nStore in a cool and dry place.\nProtect from excessive heat, moisture, and direct sunlight.\nKeep the tablets in their original packaging until use.\nStore at the temperature indicated on the product label.\nKeep out of the reach of children.\nWhy Choose METAPROLATE H 50/12.5?\n\nMETAPROLATE H 50/12.5 is formulated to provide dependable blood pressure management with the convenience of a once-daily extended-release dosage form. Manufactured according to stringent pharmaceutical quality standards, it combines two trusted antihypertensive agents in a single tablet, supporting improved treatment adherence and long-term cardiovascular care.\n\nKey Advantages\n\nExtended-release formulation for sustained therapeutic action\nCombination of two proven antihypertensive medicines\nConvenient once-daily dosing\nHigh-quality manufacturing with strict quality assurance\nReliable efficacy and consistent product performance\nSuitable for long-term hypertension management under medical supervision\nFrequently Asked Questions (FAQs)\nWhat is METAPROLATE H 50/12.5 prescribed for?\n\nIt is prescribed for the treatment of high blood pressure in adults who require combination antihypertensive therapy.\n\nHow does the extended-release formulation benefit patients?\n\nThe extended-release technology gradually releases Metoprolol throughout the day, helping maintain consistent blood levels and prolonged blood pressure control.\n\nCan I discontinue METAPROLATE H 50/12.5 on my own?\n\nNo. Beta-blockers should not be stopped suddenly, as abrupt discontinuation may increase cardiovascular risk. Always consult your healthcare provider before making any changes to your treatment.\n\nCan this medicine be used with other antihypertensive medications?\n\nYour doctor will determine whether additional blood pressure medicines are necessary based on your medical condition and treatment goals.\n\nHow long should treatment continue?\n\nHypertension is often a lifelong condition requiring continuous management. Continue taking METAPROLATE H 50/12.5 for the duration recommended by your healthcare professional, along with appropriate lifestyle modifications and regular medical follow-up.", "price": 248.0, "discountamount": 75.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2488, "imageuri": "https://productimages.withfloats.com/actual/6a6dec4fc0246085c8f72513.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a6dec4fc0246085c8f72513.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-08-01T12:53:33.409Z", "updatedon": "2026-08-01T12:53:33.409Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//metoprolol-succinate-hydrochlorthiazide-extended-release-tablets/2488", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "METAPROLATE H 50/12.5", "category": "CARDIOLOGYRANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a5092283075a19d4f2db6bd", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Cyclosporine Eye Drops 0.05% w/v", "description": "Cyclosporine eye drops 0.05% are a prescription ophthalmic emulsion used to treat chronic dry eye disease (keratoconjunctivitis sicca) caused by ocular surface inflammation. Unlike lubricating tear substitutes that only manage symptoms, cyclosporine works as a calcineurin-inhibitor immunomodulator that calms the underlying inflammation suppressing your eyes' natural tear production. It is not a steroid. The standard dose is one drop in each affected eye, twice daily, about 12 hours apart, and visible improvement in tear production typically takes 6–12 weeks, with full benefit sometimes taking up to 3–6 months of consistent use. Common side effects include temporary burning, stinging, redness, and watery eyes at the time of instillation. It is a Schedule H prescription-only medicine in India and should be used only under a qualified ophthalmologist's guidance.\n\nWhat Is Cyclosporine Eye Drops 0.05%?\nCyclosporine eye drops 0.05% (ophthalmic emulsion) is a prescription formulation designed to manage chronic dry eye disease, a condition in which the eyes fail to produce enough tears or produce tears of poor quality, often because of an underlying inflammatory process on the ocular surface and in the lacrimal (tear-producing) gland.\nThis formulation is commonly prescribed for patients whose dry eye is presumed to be due to ocular inflammation — for example, those with moderate to severe dry eye, keratoconjunctivitis sicca, or dry eye associated with conditions like Sjögren's syndrome, that has not responded adequately to artificial tears alone.\nCyclosporine belongs to a class of drugs called calcineurin inhibitors. It differs fundamentally from corticosteroid eye drops, which suppress inflammation broadly and carry risks like raised intraocular pressure and cataract formation with long-term use. Cyclosporine instead selectively dampens the T-cell-mediated inflammatory response that is thought to suppress tear gland function, allowing the eye's own tear-producing mechanism to gradually recover.\n\nHow Do Cyclosporine Eye Drops Work? (Mechanism of Action)\n\nInflammation on the ocular surface – In chronic dry eye, T-lymphocytes infiltrate the conjunctiva and lacrimal gland, triggering a self-perpetuating inflammatory cycle.\nCalcineurin inhibition – Cyclosporine binds to a cellular protein (cyclophilin) and blocks calcineurin, an enzyme required to activate T-cells.\nReduced T-cell activation – With calcineurin blocked, T-cells cannot produce the inflammatory signals (such as interleukin-2) that damage the lacrimal gland and conjunctival tissue.\nRestoration of tear production – As local inflammation subsides over weeks to months, the lacrimal gland's ability to produce natural tears gradually improves.\nImproved tear film stability – With reduced inflammation and increased natural tear volume, patients typically notice less dryness, grittiness, and ocular surface damage over time.\n\nThis is why cyclosporine drops are described as disease-modifying for dry eye rather than purely symptomatic — they address a root inflammatory cause instead of simply lubricating the eye.\n\nClinical Indications\nIndicationDetailsChronic dry eye disease (keratoconjunctivitis sicca)Primary approved use; especially where tear production is suppressed due to ocular inflammationModerate to severe dry eye not controlled by artificial tearsSecond-line option when lubricants alone are insufficientDry eye associated with autoimmune conditionsE.g., Sjögren's syndrome-related dry eye, under specialist supervisionPost-refractive surgery dry eye (select cases)Sometimes used off-label under ophthalmologist guidance\n\nDosage & Administration\nParameterRecommendationStandard doseOne drop in each affected eye, twice dailyDosing intervalApproximately 12 hours apartContact lens useRemove lenses before instillation; wait at least 15 minutes before reinsertingOnset of noticeable effectUsually 6–12 weeksFull therapeutic benefitMay take up to 3–6 months of continuous useMissed doseContinue with next scheduled dose; do not double upDiscontinuationOnly under medical advice — symptoms may return if stopped prematurely\nNote: Cyclosporine eye drops are for long-term, continuous use as directed by your ophthalmologist. Improvement is gradual, not immediate, and consistent daily use is essential for benefit.\n\nKey Benefits\n\nTargets the underlying inflammatory cause of chronic dry eye rather than only masking symptoms\nCan increase natural tear production over sustained use\nGenerally well tolerated for long-term use, since it is not a steroid and does not carry steroid-related risks like elevated eye pressure or cataract with routine use\nMay reduce dependence on frequent artificial tear instillation over time\nSuitable for long-term maintenance therapy in chronic, relapsing dry eye disease\nCan improve comfort during visually demanding tasks (screen use, reading, driving) affected by chronic dryness\n\n\nPrecautions\n\nUse strictly as prescribed by an ophthalmologist; do not self-medicate\nNot intended for immediate relief of dry eye symptoms — artificial tears may be used concurrently for interim comfort as advised by your doctor\nShould not be used in the presence of an active ocular infection unless specifically directed by a physician\nInform your doctor if you are pregnant, breastfeeding, or have any known hypersensitivity to cyclosporine or emulsion components\nAvoid touching the dropper tip to the eye or any surface to prevent contamination\nIf wearing contact lenses, remove before application and reinsert only after 15 minutes\nDo not use expired or previously opened single-use vials, if applicable to your product format\nRegular ophthalmic follow-up is recommended to monitor treatment response\n\n\nSide Effects\nCommon (Usually Mild and Temporary)\n\nBurning or stinging sensation upon instillation\nEye redness\nWatery eyes (excessive tearing)\nEye discomfort or a feeling of something in the eye\nTemporary blurred vision immediately after application\n\nLess Common / Serious (Consult Your Doctor Promptly)\n\nPersistent or worsening eye pain\nSigns of eye infection (discharge, significant redness, swelling)\nVisual disturbance that does not resolve\nSigns of an allergic reaction (eyelid swelling, itching, rash)\n\nIf any serious or persistent symptom occurs, discontinue use and consult your ophthalmologist immediately.\n\nComparison: Cyclosporine Eye Drops vs. Other Dry Eye Treatments\nTreatmentMechanismOnset of ActionLong-Term Use ProfileCyclosporine 0.05% dropsCalcineurin inhibitor; reduces inflammation, restores natural tear productionWeeks to monthsGenerally suitable for continuous long-term useArtificial tears / lubricantsSymptomatic lubrication onlyImmediate, short-livedSafe but does not address inflammation; frequent reapplication neededCorticosteroid eye dropsBroad anti-inflammatory actionFast (days)Not recommended for long-term use due to risk of raised IOP, cataractLifitegrast ophthalmic solutionLFA-1 antagonist; blocks a different inflammatory pathwayWeeksAlternative option, mechanism differs from cyclosporine\n\nKey Statistics (Placeholder — Pending Clinical Reviewer Verification)\nMetricValueReported patients showing improved tear production at 6 months[Placeholder – insert verified clinical trial statistic]Prevalence of chronic dry eye disease in adults[Placeholder – insert epidemiological reference]Average time to symptomatic improvement[Placeholder – insert verified reference range]\nAll statistics above are placeholders and must be verified and populated by a qualified clinical reviewer prior to publication.\n\nExpert Insight\n\n[Placeholder — Expert quote pending. To be added only after review and approval by a licensed ophthalmologist/medical reviewer associated with Steris Healthcare. Do not fabricate or publish without sign-off.]\n\n\nPrice of Cyclosporine Eye Drops 0.05%\nThe price of cyclosporine eye drops 0.05% varies depending on pack size, brand, and region. For current pricing, availability, and prescription verification, please consult your ophthalmologist or authorized pharmacy.\nPrescription only – consult your doctor.\n\nConclusion\nCyclosporine eye drops 0.05% represent a meaningful shift in how chronic dry eye disease is managed — moving beyond temporary lubrication to address the underlying inflammatory process that suppresses natural tear production. For patients with moderate to severe dry eye that hasn't responded well to artificial tears alone, this calcineurin-inhibitor therapy offers a disease-modifying option that, with consistent long-term use, can meaningfully improve ocular comfort and tear film health. Because benefits build gradually over weeks to months, patience and adherence to the prescribed twice-daily regimen are essential. As with any prescription ophthalmic therapy, cyclosporine eye drops should only be used under the guidance of a qualified ophthalmologist, who can confirm suitability, monitor progress, and adjust care as needed.\n\nFrequently Asked Questions\n\n1. What are cyclosporine 0.05% eye drops used for?\nCyclosporine 0.05% eye drops are used to treat chronic dry eye disease caused by ocular surface inflammation. They help increase natural tear production in patients whose tear glands are suppressed due to inflammation, particularly when artificial tears alone aren't enough.\n\n2. How long can I use cyclosporine eye drops?\nCyclosporine eye drops are typically used long-term, as chronic dry eye is an ongoing condition. Many patients continue therapy for months to years under regular ophthalmologist supervision, since symptoms can return if the medication is stopped.\n\n3. Is Cyclomune a steroid?\nNo. Cyclomune (a brand of cyclosporine ophthalmic emulsion) is not a steroid. It is a calcineurin-inhibitor immunomodulator that works differently from steroid eye drops and does not carry the same risk of raised eye pressure or cataract associated with long-term steroid use.\n4. How quickly do cyclosporine eye drops start working?\nMost patients begin noticing improvement in tear production and dry eye symptoms within 6 to 12 weeks, though full benefit may take up to 3 to 6 months of consistent, twice-daily use.\n\n5. Can cyclosporine damage eyes?\nWhen used exactly as prescribed, cyclosporine eye drops are generally considered safe for long-term use. Temporary burning, stinging, or watering can occur at the time of instillation, but serious eye damage is uncommon. Any persistent pain, vision changes, or signs of infection should be reported to your ophthalmologist promptly.\n\n6. How much are cyclosporine 0.05% eye drops?\nPricing varies by brand, pack size, and region. Since this is a prescription-only medicine, please check current pricing with your prescribing doctor or a licensed pharmacy.\n\n7. Is cyclosporine a steroid?\nNo. Cyclosporine is a calcineurin inhibitor, a category of immunomodulating medication that is pharmacologically distinct from corticosteroids (steroids), even though both can reduce inflammation.\n\n8. Can I wear contact lenses while using cyclosporine eye drops?\nContact lenses should be removed before applying the drops and can typically be reinserted after about 15 minutes, unless your ophthalmologist gives different instructions.\n9. What happens if I stop using cyclosporine eye drops suddenly?\nStopping suddenly may cause dry eye symptoms to gradually return, since the underlying inflammation is no longer being managed. Always consult your doctor before discontinuing treatment.\n\n10. Can cyclosporine eye drops be used with artificial tears?\nYes, in many cases artificial tears can be used alongside cyclosporine drops for additional comfort, especially during the initial weeks before cyclosporine's full effect develops. Confirm timing and spacing with your doctor.\n\n11. Who should not use cyclosporine eye drops?\nPatients with known hypersensitivity to cyclosporine or its components, active untreated eye infections, or specific contraindications identified by their doctor should not use this medication without medical clearance.\n\n12. Are cyclosporine eye drops safe during pregnancy?\nUse during pregnancy or breastfeeding should only occur under medical supervision. Inform your doctor if you are pregnant, planning pregnancy, or breastfeeding before starting treatment.\n\n13. What is the difference between cyclosporine eye drops and lubricating eye drops?\nLubricating (artificial tear) drops provide temporary symptomatic relief by adding moisture to the eye, while cyclosporine drops target the underlying inflammation responsible for reduced natural tear production, offering a longer-term, disease-modifying approach.\n\n14. Can children use cyclosporine eye drops?\nUse in children should only be under the direct guidance and prescription of a pediatric ophthalmologist, based on individual clinical assessment.\n\n15. Do cyclosporine eye drops cause blurred vision?\nTemporary blurred vision can occur immediately after instillation in some patients. This usually resolves quickly. If blurred vision persists, consult your doctor.\n\n16. Can cyclosporine eye drops be used with other eye medications?\nOther eye medications, including other prescription drops, should only be combined with cyclosporine under your ophthalmologist's guidance, with appropriate spacing between different drops.\n\n17. Why do cyclosporine eye drops take so long to work?\nBecause cyclosporine works by gradually reducing chronic inflammation in the lacrimal gland and ocular surface rather than providing instant lubrication, visible improvement in natural tear production takes weeks to months rather than being immediate.", "price": 495.0, "discountamount": 149.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2468, "imageuri": "https://productimages.withfloats.com/actual/6a50922a464ced2a630398a1.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a50922a464ced2a630398a1.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-07-10T06:33:12.096Z", "updatedon": "2026-07-10T06:33:12.096Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//cyclosporine-eye-drops-0-05-w-v/2468", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "CIPVISION CYCLOPURE 0.5 mg", "category": "Opthalmology Range", "tags": [ "Cyclosporine Eye Drops 0.05% w/v", "cyclosporine eye drops", "cyclosporine eye drops uses", "cyclosporine eye drops ip 0.05 w/v", "cyclosporine eye drops price", "cyclosporine eye drops uses in hindi", "cyclosporine eye drops side effects", "cyclosporine eye drops 0.05", "cyclosporine eye drops brand name", "cyclosporine eye drops india" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a323d7d8e48e7ba2094cc7f", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "nimodipine 60 mg", "description": "When looking for an effective medication for specific neurological and blood vessel-related conditions, Nimodipine 60 mg is a widely prescribed treatment known for its role in improving blood flow to the brain. Healthcare professionals commonly recommend this medicine for patients requiring specialized management of cerebral blood vessel complications.\n\nIf you are researching Nimodipine 60 mg, understanding its uses, benefits, dosage, safety profile, and purchasing considerations can help you make an informed decision. This comprehensive guide covers everything you need to know before buying or using Nimodipine 60 mg.\n\nWhat Is Nimodipine 60 mg?\n\nNimodipine 60 mg is a prescription medication that belongs to a class of drugs called calcium channel blockers. Unlike many calcium channel blockers that primarily affect the heart and peripheral blood vessels, nimodipine is specially designed to target blood vessels in the brain.\n\nIt is most commonly used to reduce the risk of brain damage caused by decreased blood flow following certain neurological events. By relaxing and widening cerebral blood vessels, nimodipine helps maintain adequate oxygen and nutrient delivery to brain tissue.\n\nBecause of its specialized action, Nimodipine 60 mg should only be used under medical supervision and according to prescribed treatment guidelines.\n\nComposition of Nimodipine 60 mg\n\nEach tablet contains:\n\nIngredient\tStrength\nNimodipine\t60 mg\n\nThe active ingredient works by controlling the movement of calcium into smooth muscle cells of blood vessels, helping them remain relaxed and open.\n\nHow Does Nimodipine 60 mg Work?\n\nNimodipine acts by blocking calcium channels located in the smooth muscle cells lining blood vessel walls.\n\nMechanism of Action\nCalcium normally enters vascular smooth muscle cells.\nThis calcium causes blood vessels to contract.\nNimodipine blocks calcium entry.\nBlood vessels relax and widen.\nImproved blood flow reaches brain tissues.\n\nThe unique property of nimodipine is its high affinity for cerebral arteries. This makes it particularly valuable in neurological settings where maintaining adequate cerebral circulation is critical.\n\nBy reducing blood vessel constriction, Nimodipine 60 mg helps support oxygen delivery and may lower the risk of complications associated with reduced cerebral blood flow.\n\nUses of Nimodipine 60 mg\n\nHealthcare providers may prescribe Nimodipine 60 mg for the management of conditions involving cerebral circulation.\n\nCommon Medical Uses\n1. Prevention of Cerebral Vasospasm\n\nNimodipine is widely used to prevent narrowing of brain blood vessels after certain neurological events.\n\n2. Support of Brain Blood Flow\n\nThe medication helps improve circulation in cerebral arteries and supports oxygen supply to brain tissues.\n\n3. Neurological Care Protocols\n\nIn specialized hospital settings, nimodipine may form part of comprehensive neurological treatment plans.\n\n4. Reduction of Ischemic Complications\n\nBy maintaining adequate blood flow, the medication may help reduce complications associated with restricted cerebral circulation.\n\nAlways follow your doctor's recommendations regarding the exact purpose and duration of treatment.\n\nKey Benefits of Nimodipine 60 mg\nImproved Cerebral Blood Flow\n\nThe primary benefit of Nimodipine 60 mg is its ability to enhance blood circulation within the brain.\n\nTargeted Action\n\nUnlike many other calcium channel blockers, nimodipine specifically affects cerebral blood vessels.\n\nNeuroprotective Support\n\nMaintaining adequate blood flow helps support brain tissue function and recovery.\n\nWell-Established Clinical Use\n\nNimodipine has been extensively studied and is commonly included in neurological treatment protocols worldwide.\n\nReliable Therapeutic Effect\n\nWhen taken as prescribed, Nimodipine 60 mg provides consistent therapeutic support for cerebral vascular health.\n\nWhy Choose Nimodipine 60 mg?\n\nMany healthcare professionals choose nimodipine because of its unique brain-selective properties.\n\nAdvantages Include:\nSpecifically targets cerebral arteries\nSupports healthy blood circulation in the brain\nProven clinical history\nPrescription-based safety monitoring\nWidely recognized neurological therapy\nSuitable for structured treatment protocols\n\nPatients searching for Nimodipine 60 mg online often prioritize quality, authenticity, and professional medical guidance when purchasing this medication.\n\nDosage and Administration\n\nThe dosage of Nimodipine 60 mg depends on individual medical needs and physician recommendations.\n\nGeneral Guidelines\nTake exactly as prescribed.\nSwallow the tablet with water.\nFollow scheduled dosing intervals.\nDo not exceed the prescribed dose.\nContinue treatment for the full duration recommended by your healthcare provider.\nImportant Instructions\nAvoid self-adjusting the dosage.\nDo not stop treatment abruptly unless advised by your doctor.\nInform your physician about all medications you are taking.\n\nBecause dosing schedules may vary, always rely on professional medical advice.\n\nPossible Side Effects of Nimodipine 60 mg\n\nLike all prescription medicines, Nimodipine 60 mg may cause side effects in some individuals.\n\nCommon Side Effects\nHeadache\nDizziness\nFlushing\nNausea\nFatigue\nLow blood pressure\nLess Common Side Effects\nRapid heartbeat\nSwelling of extremities\nGastrointestinal discomfort\nLightheadedness\nSeek Medical Attention If You Experience\nSevere allergic reactions\nSignificant drop in blood pressure\nDifficulty breathing\nSevere dizziness or fainting\n\nMost side effects are manageable and should be discussed with your healthcare provider.\n\nSafety Precautions\n\nBefore using Nimodipine 60 mg, discuss your complete medical history with your doctor.\n\nInform Your Physician If You Have:\nLiver disease\nLow blood pressure\nHeart conditions\nKidney disorders\nHistory of medication allergies\nPregnancy and Breastfeeding\n\nConsult your healthcare provider regarding the use of Nimodipine 60 mg during pregnancy or breastfeeding.\n\nDrug Interactions\n\nCertain medications may interact with nimodipine, including:\n\nBlood pressure medications\nAntifungal drugs\nAntibiotics\nAnti-seizure medications\nCertain heart medications\n\nAlways provide a complete medication list to your healthcare professional.\n\nHow to Store Nimodipine 60 mg\n\nProper storage helps maintain the medication's effectiveness.\n\nStorage Guidelines\nStore at room temperature.\nKeep away from direct sunlight.\nProtect from moisture.\nKeep out of reach of children.\nStore in original packaging whenever possible.\n\nDo not use expired medication.\n\nBuying Nimodipine 60 mg Online\n\nWhen purchasing Nimodipine 60 mg online, prioritize safety and authenticity.\n\nWhat to Look For\nLicensed pharmacy or supplier\nGenuine product sourcing\nPrescription verification\nSecure payment methods\nProper packaging\nCustomer support availability\nBuyer Checklist\n\n✔ Verify product strength (60 mg)\n\n✔ Check manufacturing details\n\n✔ Confirm prescription requirements\n\n✔ Review storage recommendations\n\n✔ Ensure sealed packaging upon delivery\n\nChoosing a reputable supplier helps ensure product quality and patient safety.\n\nConclusion\n\nNimodipine 60 mg is a specialized calcium channel blocker designed to support healthy cerebral blood flow. Its targeted action on brain blood vessels makes it an important medication in neurological care and vascular management protocols.\n\nWhether you are researching treatment options or planning to purchase Nimodipine 60 mg with a valid prescription, understanding its benefits, dosage guidelines, precautions, and potential side effects is essential. Always use this medication under the supervision of a qualified healthcare professional to achieve the best possible outcomes.\n\nHigh-Ranking FAQs (Google Search & Voice Search Optimized)\nWhat is Nimodipine 60 mg used for?\n\nNimodipine 60 mg is primarily used to improve blood flow in the brain and help prevent complications related to cerebral blood vessel narrowing under medical supervision.\n\nHow does Nimodipine 60 mg work?\n\nIt blocks calcium entry into blood vessel muscle cells, allowing cerebral arteries to relax and improving blood circulation to brain tissues.\n\nIs Nimodipine 60 mg a blood thinner?\n\nNo. Nimodipine is not a blood thinner. It is a calcium channel blocker that relaxes blood vessels.\n\nCan Nimodipine 60 mg lower blood pressure?\n\nYes. Nimodipine may lower blood pressure as part of its blood vessel-relaxing effects.\n\nHow long should I take Nimodipine 60 mg?\n\nThe duration of treatment depends on your medical condition and your doctor's recommendations.\n\nCan I take Nimodipine 60 mg with food?\n\nFollow your physician's instructions regarding food intake and dosing schedules for optimal results.\n\nWhat are the most common side effects of Nimodipine 60 mg?\n\nCommon side effects include headache, dizziness, nausea, flushing, fatigue, and low blood pressure.\n\nIs Nimodipine 60 mg available without a prescription?\n\nNo. Nimodipine 60 mg is generally a prescription-only medication and should be used under medical supervision.\n\nCan elderly patients use Nimodipine 60 mg?\n\nYes, but dosage and monitoring should be determined by a healthcare professional based on individual health conditions.\n\nWhere can I buy genuine Nimodipine 60 mg online?\n\nYou should purchase Nimodipine 60 mg only from reputable and licensed pharmacies that provide authentic prescription medications and proper product information.", "price": 240.0, "discountamount": 72.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2455, "imageuri": "https://productimages.withfloats.com/actual/6a323d80854c6b9cdfe7c9ab.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a323d80854c6b9cdfe7c9ab.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-06-17T06:23:57.291Z", "updatedon": "2026-06-17T06:58:50.317Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//nimodipine-60-mg/2455", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "NIMONIDIP 60", "category": "CARDIOLOGYRANGE", "tags": [ "nimodipine 60 mg", "nimodipine 60 mg price", "tab nimodipine 60 mg", "nimodipine 60 mg uses in hindi", "tab nimodipine 60 mg uses", "nimodipine 60 mg brand name", "tab nimodipine 60 mg uses in hindi", "nimodipine 60 mg tablet uses", "nimodipine 60 mg tablet uses", "nimodipine 60 mg price in india" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a26b8348e598f29a23bee71", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Aceclofenac Paracetamol Phenylephrine Hci Cetirizine Hci & Caffeine Tablets", "description": "What Are Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets?\n\nAceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets are a combination medicine commonly prescribed for the symptomatic relief of fever, body pain, headache, nasal congestion, cold, flu, and allergic conditions. This multi-action formulation combines anti-inflammatory, analgesic, antihistamine, decongestant, and stimulant properties to provide comprehensive relief from multiple symptoms associated with upper respiratory tract infections and seasonal allergies.\n\nThe combination is designed to target the root causes of discomfort by reducing inflammation, lowering fever, relieving pain, controlling allergic reactions, and improving alertness. Due to its broad-spectrum symptom management, it is widely used by healthcare professionals for patients experiencing cold, flu-like symptoms, sinus congestion, allergic rhinitis, and associated body aches.\n\nComposition of Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets\n\nThe formulation contains the following active ingredients:\n\nAceclofenac\n\nA non-steroidal anti-inflammatory drug (NSAID) used to reduce inflammation, swelling, and pain.\n\nParacetamol (Acetaminophen)\n\nA well-known analgesic and antipyretic that helps reduce fever and relieve mild to moderate pain.\n\nPhenylephrine Hydrochloride\n\nA nasal decongestant that helps shrink swollen blood vessels in the nasal passages, making breathing easier.\n\nCetirizine Hydrochloride\n\nA second-generation antihistamine used to control allergy symptoms such as sneezing, runny nose, watery eyes, and itching.\n\nCaffeine\n\nA central nervous system stimulant that helps combat fatigue and enhances the pain-relieving effects of analgesics.\n\nHow Do Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets Work?\n\nThis advanced combination works through multiple mechanisms to provide effective symptom relief.\n\nPain and Inflammation Reduction\n\nAceclofenac blocks the production of inflammatory chemicals called prostaglandins. This helps reduce pain, swelling, and inflammation associated with infections and other conditions.\n\nFever Control\n\nParacetamol acts on the temperature-regulating center in the brain to lower fever and reduce discomfort.\n\nRelief from Nasal Congestion\n\nPhenylephrine constricts blood vessels inside the nasal passages, reducing swelling and opening blocked airways.\n\nAllergy Symptom Management\n\nCetirizine blocks histamine receptors and prevents allergic reactions such as sneezing, itching, and excessive mucus production.\n\nImproved Alertness and Enhanced Pain Relief\n\nCaffeine stimulates the central nervous system, helping reduce tiredness while boosting the effectiveness of pain-relieving ingredients.\n\nTogether, these ingredients provide fast and comprehensive relief from multiple symptoms.\n\nMechanism of Each Ingredient\nAceclofenac\nMechanism of Action\n\nAceclofenac inhibits cyclooxygenase (COX) enzymes responsible for producing prostaglandins that cause inflammation and pain.\n\nTherapeutic Effects\nReduces inflammation\nRelieves body aches\nDecreases joint and muscle pain\nImproves comfort during infections\nParacetamol\nMechanism of Action\n\nParacetamol acts primarily in the central nervous system to inhibit pain signals and regulate body temperature.\n\nTherapeutic Effects\nLowers fever\nRelieves headache\nReduces mild to moderate pain\nImproves overall comfort\nPhenylephrine Hydrochloride\nMechanism of Action\n\nPhenylephrine stimulates alpha-adrenergic receptors in blood vessels, causing vasoconstriction.\n\nTherapeutic Effects\nRelieves blocked nose\nImproves airflow\nReduces sinus pressure\nHelps easier breathing\nCetirizine Hydrochloride\nMechanism of Action\n\nCetirizine selectively blocks H1 histamine receptors and prevents allergic responses.\n\nTherapeutic Effects\nReduces sneezing\nControls runny nose\nRelieves itching\nReduces watery eyes\nCaffeine\nMechanism of Action\n\nCaffeine stimulates the central nervous system and enhances analgesic efficacy.\n\nTherapeutic Effects\nReduces fatigue\nEnhances alertness\nImproves concentration\nSupports faster symptom relief\nKey Benefits of Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets\nComprehensive Symptom Relief\n\nThe combination addresses multiple symptoms simultaneously, reducing the need for multiple medications.\n\nFast Pain Relief\n\nProvides effective relief from headaches, body aches, muscle pain, and throat discomfort.\n\nEffective Fever Reduction\n\nHelps control elevated body temperature associated with viral and bacterial infections.\n\nClears Nasal Congestion\n\nPhenylephrine helps restore normal breathing by reducing nasal blockage.\n\nControls Allergy Symptoms\n\nCetirizine effectively manages allergic reactions and respiratory irritation.\n\nEnhances Daily Productivity\n\nCaffeine helps reduce fatigue and supports normal daily activities.\n\nConvenient Single-Tablet Therapy\n\nCombines multiple therapeutic actions into one convenient dosage form.\n\nUses of Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets\n\nHealthcare professionals may prescribe this combination for:\n\nCommon Cold\n\nProvides relief from:\n\nSneezing\nNasal congestion\nRunny nose\nFever\nBody aches\nInfluenza (Flu)\n\nHelps manage:\n\nFever\nChills\nHeadache\nMuscle pain\nFatigue\nAllergic Rhinitis\n\nReduces:\n\nNasal irritation\nSneezing\nItching\nWatery eyes\nSinusitis\n\nProvides relief from:\n\nSinus pressure\nFacial pain\nNasal blockage\nFever with Body Pain\n\nEffective in reducing discomfort associated with infections.\n\nHeadaches\n\nUseful for headache relief caused by fever, sinus congestion, and upper respiratory tract infections.\n\nWhy Choose Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets?\nMulti-Ingredient Advantage\n\nThe formulation targets multiple symptoms through different mechanisms of action.\n\nImproved Patient Compliance\n\nA single tablet simplifies treatment and improves adherence.\n\nBalanced Symptom Management\n\nProvides relief from pain, fever, congestion, and allergies simultaneously.\n\nRapid Onset of Action\n\nThe ingredients work together to deliver quick and effective relief.\n\nEnhanced Therapeutic Effect\n\nCaffeine improves the effectiveness of pain-relieving agents while reducing fatigue.\n\nSuitable for Seasonal Illnesses\n\nParticularly beneficial during cold, flu, allergy, and seasonal infection outbreaks.\n\nImportant Safety Information\n\nBefore using Aceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets, consider the following precautions:\n\nUse Only Under Medical Supervision\n\nAlways follow the dosage prescribed by a qualified healthcare professional.\n\nAvoid Alcohol Consumption\n\nAlcohol may increase the risk of liver damage and enhance side effects such as dizziness.\n\nLiver Disease Precaution\n\nPatients with liver disorders should use this medication cautiously due to the presence of paracetamol.\n\nKidney Disease Precaution\n\nDose adjustment may be required in patients with kidney impairment.\n\nHeart and Blood Pressure Conditions\n\nPhenylephrine may increase blood pressure; patients with hypertension should consult their physician before use.\n\nPregnancy and Breastfeeding\n\nUse only if specifically recommended by a healthcare professional.\n\nDriving and Machinery Operation\n\nCetirizine may cause drowsiness in some individuals. Exercise caution while driving or operating machinery.\n\nAvoid Overdose\n\nTaking more than the recommended dose can result in serious liver injury and other complications.\n\nDrug Interactions\n\nInform your healthcare provider if you are taking:\n\nBlood thinners\nAntihypertensive medications\nOther cold and flu medicines\nSedatives\nAntidepressants\nNSAIDs\nPossible Side Effects\n\nLike all medicines, this combination may cause side effects in some individuals.\n\nCommon side effects may include:\n\nDrowsiness\nDizziness\nDry mouth\nNausea\nStomach discomfort\nIncreased heart rate\nNervousness\nInsomnia\nHeadache\n\nSeek immediate medical attention if severe allergic reactions, breathing difficulties, swelling, or severe skin reactions occur.\n\nStorage Instructions\nStore in a cool and dry place.\nKeep away from direct sunlight and moisture.\nStore below the recommended temperature.\nKeep out of reach of children.\nDo not use after the expiry date.\nConclusion\n\nAceclofenac Paracetamol Phenylephrine HCl Cetirizine HCl & Caffeine Tablets offer a comprehensive solution for managing cold, flu, allergy, fever, headache, body pain, and nasal congestion. By combining the anti-inflammatory action of Aceclofenac, fever-reducing effects of Paracetamol, decongestant benefits of Phenylephrine, antihistamine properties of Cetirizine, and the alertness-enhancing effects of Caffeine, this formulation delivers multi-symptom relief in a single tablet.", "price": 80.0, "discountamount": 24.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2449, "imageuri": "https://productimages.withfloats.com/actual/6a26b8363079272b422ed2db.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a26b8363079272b422ed2db.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-06-08T12:40:20.088Z", "updatedon": "2026-06-08T12:40:20.088Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//aceclofenac-paracetamol-phenylephrine-hci-cetirizine-hci-caffeine-tablets/2449", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "METAPECT COLD PLUS", "category": "GENERAL RANGE", "tags": [ "Aceclofenac Paracetamol Phenylephrine Hci Cetirizine Hci & Caffeine Tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6a2668811520c1ae186c6647", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "travoprost and timolol maleate eye drops", "description": "Travoprost Timolol Eye Drops\n\nIf you are looking for a trusted and clinically proven solution to manage elevated eye pressure associated with glaucoma or ocular hypertension, Travoprost Timolol Eye Drops offer an effective dual-action treatment. This combination medication is widely prescribed by ophthalmologists to help reduce intraocular pressure (IOP), protect the optic nerve, and lower the risk of vision loss caused by progressive eye diseases.\n\nTravoprost Timolol Eye Drops combine two powerful active ingredients—Travoprost, a prostaglandin analog, and Timolol, a beta-blocker. Together, they work through complementary mechanisms to provide superior pressure control compared to many single-agent treatments. For patients who require enhanced management of eye pressure, this combination offers convenience, efficacy, and long-term protection.\n\nThis comprehensive guide explains the uses, benefits, mechanism of action, dosage guidance, side effects, and reasons why Travoprost Timolol Eye Drops are a preferred choice among eye care professionals and patients.\n\nWhat Are Travoprost Timolol Eye Drops?\n\nTravoprost Timolol Eye Drops are prescription ophthalmic drops used primarily to reduce increased intraocular pressure in individuals suffering from:\n\nOpen-angle glaucoma\nOcular hypertension\nChronic glaucoma management\nElevated eye pressure resistant to monotherapy\n\nHigh eye pressure can gradually damage the optic nerve, leading to permanent vision loss if left untreated. Travoprost Timolol Eye Drops help maintain healthy eye pressure levels and preserve visual function.\n\nThe combination includes:\n\nTravoprost\n\nTravoprost belongs to a class of medications known as prostaglandin analogs. It works by increasing the natural drainage of fluid from the eye.\n\nTimolol\n\nTimolol is a non-selective beta-blocker that reduces the production of aqueous humor, the fluid responsible for maintaining pressure within the eye.\n\nTogether, these ingredients provide a comprehensive approach to lowering intraocular pressure.\n\nHow Travoprost Timolol Eye Drops Work\n\nThe effectiveness of Travoprost Timolol Eye Drops comes from their dual-action mechanism.\n\nTravoprost Action\n\nTravoprost improves the outflow of aqueous humor through the uveoscleral pathway. As more fluid drains from the eye, intraocular pressure decreases.\n\nTimolol Action\n\nTimolol reduces the amount of aqueous humor produced by the ciliary body inside the eye. Lower fluid production helps maintain optimal pressure levels.\n\nCombined Benefits\n\nBy simultaneously increasing fluid drainage and decreasing fluid production, Travoprost Timolol Eye Drops provide stronger and more consistent pressure control than either component alone.\n\nThis dual mechanism makes them particularly effective for patients requiring significant reduction in intraocular pressure.\n\nUses of Travoprost Timolol Eye Drops\n1. Open-Angle Glaucoma\n\nOpen-angle glaucoma is one of the most common forms of glaucoma. Travoprost Timolol Eye Drops help lower eye pressure and reduce the risk of optic nerve damage.\n\n2. Ocular Hypertension\n\nPatients with elevated eye pressure but no visible optic nerve damage can benefit from pressure reduction to prevent future complications.\n\n3. Long-Term Glaucoma Management\n\nThese eye drops are often prescribed as part of a long-term treatment plan to maintain stable eye pressure levels.\n\n4. Inadequate Response to Single Therapy\n\nPatients who do not achieve sufficient pressure control with a single medication may be switched to this combination therapy.\n\n5. Prevention of Vision Loss\n\nConsistent control of intraocular pressure helps minimize the progression of glaucoma-related vision impairment.\n\nKey Benefits of Travoprost Timolol Eye Drops\nPowerful Intraocular Pressure Reduction\n\nThe dual-action formula provides significant and sustained lowering of eye pressure.\n\nTwo Medications in One Drop\n\nCombining two proven therapies into a single formulation improves convenience and treatment adherence.\n\nReduced Risk of Optic Nerve Damage\n\nMaintaining healthy eye pressure levels helps protect the optic nerve from progressive damage.\n\nLong-Lasting Effectiveness\n\nMany patients achieve effective pressure control with once-daily administration as prescribed by their ophthalmologist.\n\nEnhanced Treatment Compliance\n\nUsing a combination product may reduce the need for multiple eye medications, simplifying treatment routines.\n\nProven Clinical Performance\n\nBoth Travoprost and Timolol have extensive clinical use and are well-established in glaucoma management.\n\nSupports Long-Term Vision Preservation\n\nRegular use can help slow disease progression and maintain visual function.\n\nWho Should Consider Travoprost Timolol Eye Drops?\n\nTravoprost Timolol Eye Drops may be suitable for:\n\nAdults diagnosed with open-angle glaucoma\nPatients with ocular hypertension\nIndividuals requiring stronger eye pressure control\nPatients not adequately controlled on single-agent therapy\nPeople seeking a convenient combination treatment\nIndividuals at risk of glaucoma progression\n\nOnly an eye specialist can determine whether this medication is appropriate based on individual eye health and medical history.\n\nHow to Use Travoprost Timolol Eye Drops\n\nFor best results, use the eye drops exactly as prescribed.\n\nGeneral Application Steps\nWash your hands thoroughly.\nShake the bottle if instructed.\nTilt your head backward.\nPull down the lower eyelid gently.\nInstill the prescribed number of drops.\nClose your eyes for one to two minutes.\nAvoid touching the dropper tip to any surface.\nReplace the cap securely after use.\n\nIf using multiple eye medications, allow an interval between applications according to your healthcare provider's instructions.\n\nWhy Buyers Choose Travoprost Timolol Eye Drops\n\nWhen purchasing glaucoma medications, patients and caregivers often prioritize effectiveness, convenience, and long-term protection. Travoprost Timolol Eye Drops are a preferred option because they address multiple treatment goals simultaneously.\n\nBuyer-Focused Advantages\nEffective reduction of elevated eye pressure\nConvenient dual-action formula\nTrusted glaucoma treatment\nReduced medication burden\nSupports optic nerve health\nLong-term disease management\nWidely prescribed by ophthalmologists\nProven safety and efficacy profile\n\nThese qualities make Travoprost Timolol Eye Drops a reliable choice for glaucoma and ocular hypertension management.\n\nPrecautions Before Using Travoprost Timolol Eye Drops\n\nBefore starting treatment, inform your healthcare provider if you have:\n\nAsthma\nChronic obstructive pulmonary disease (COPD)\nHeart disease\nSlow heart rate\nDiabetes\nThyroid disorders\nHistory of severe allergic reactions\nEye infections or recent eye surgery\n\nTimolol may be absorbed into the bloodstream and can affect certain medical conditions. Regular monitoring may be required.\n\nPossible Side Effects of Travoprost Timolol Eye Drops\n\nLike all medications, Travoprost Timolol Eye Drops may cause side effects in some individuals.\n\nCommon Side Effects\nEye redness\nMild burning or stinging\nTemporary blurred vision\nEye irritation\nIncreased tear production\nDry eyes\nForeign body sensation\nTravoprost-Related Effects\nGradual darkening of the iris\nIncreased eyelash growth\nChanges in eyelash thickness\nEyelid skin darkening\nTimolol-Related Effects\nSlower heart rate\nFatigue\nDizziness\nShortness of breath in susceptible individuals\n\nSeek immediate medical attention if severe allergic reactions, chest pain, breathing difficulties, or significant vision changes occur.\n\nStorage Instructions\n\nTo maintain effectiveness and sterility:\n\nStore at room temperature.\nProtect from excessive heat and direct sunlight.\nKeep the bottle tightly closed.\nDo not use after the expiration date.\nKeep out of reach of children.\n\nAlways follow the storage recommendations provided on the product label.\n\nFrequently Asked Questions\nCan Travoprost Timolol Eye Drops cure glaucoma?\n\nNo. Glaucoma cannot currently be cured, but these eye drops help control eye pressure and slow disease progression.\n\nHow long does it take to work?\n\nThe medication begins lowering eye pressure soon after administration, with continued benefits during regular use.\n\nCan contact lens wearers use these drops?\n\nContact lenses may need to be removed before application and reinserted later according to your doctor's guidance.\n\nIs daily use necessary?\n\nYes. Consistent daily use is important for maintaining stable intraocular pressure and protecting vision.\n\nConclusion\n\nTravoprost Timolol Eye Drops are an advanced combination therapy designed to effectively manage elevated intraocular pressure associated with glaucoma and ocular hypertension. By combining the pressure-lowering effects of Travoprost and Timolol, these eye drops provide comprehensive, long-lasting control that helps protect the optic nerve and preserve vision.\n\nWhether you require stronger glaucoma management or a more convenient treatment option, Travoprost Timolol Eye Drops offer a trusted solution backed by extensive clinical experience. With benefits including powerful pressure reduction, simplified dosing, and support for long-term eye health, they remain a preferred choice for patients seeking reliable glaucoma care.", "price": 370.0, "discountamount": 111.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2441, "imageuri": "https://productimages.withfloats.com/actual/6a266883540c0a56c664ff96.png", "tileimageuri": "https://productimages.withfloats.com/tile/6a266883540c0a56c664ff96.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-06-08T07:00:17.345Z", "updatedon": "2026-06-08T07:00:17.345Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//travoprost-and-timolol-maleate-eye-drops/2441", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "CIPVISION TAFLOPROST TIMO", "category": "Opthalmology Range", "tags": [ "travoprost timolol eye drops", "travoprost timolol", "travoprost timolol", "travoprost timolol combination brands", "travoprost timolol eye drops brand name", "travoprost timolol brand", "travoprost timolol eye drops uses in hindi", "travoprost timolol brand name", "travoprost timolol eye drops price" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "69e9f8f5051af90911258c1b", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "nebivolol 5mg cilnidipine 10mg", "description": "Nebivolol 5mg + Cilnidipine 10mg Tablets—Complete Guide\nA fixed-dose combination antihypertensive for effective blood pressure control. Understand how it works, who it's for, dosage, and safety before you buy.\n\nDrug Class\nBeta-blocker + Calcium Channel Blocker\nStrength\nNebivolol 5mg / Cilnidipine 10mg\nRoute\nOral (tablet)\nSchedule\nRx Only\nWhat is this combination?\nUnderstanding nebivolol 5mg + cilnidipine 10mg\nNebivolol 5mg + cilnidipine 10mg is a fixed-dose combination tablet prescribed for the management of hypertension (high blood pressure) in adults. It pairs two complementary mechanisms into one convenient pill, making it a popular choice when single-drug therapy proves insufficient for adequate blood pressure control.\n\nThis combination is widely preferred by cardiologists when patients need better BP reduction with fewer pills, improved tolerability, and protection of vital organs such as the heart and kidneys. If your doctor has prescribed this tablet, you're likely being treated for stage 1 or stage 2 hypertension, with or without associated cardiovascular risk factors.\n\nThis is not an over-the-counter product. Always use nebivolol + cilnidipine tablets only under the supervision of a licensed physician. Self-medication or dose changes without medical advice can be dangerous.\nHow it works\nMechanism of action — dual-pathway blood pressure control\nThe effectiveness of this combination lies in how its two active ingredients target blood pressure through different pathways simultaneously:\n\nNebivolol 5mg\nA third-generation cardioselective beta-1 blocker. It slows the heart rate, reduces the force of cardiac contraction, and lowers cardiac output. Uniquely, nebivolol also releases nitric oxide, causing blood vessel relaxation — a property not seen in older beta-blockers. This makes it better tolerated and less likely to cause sexual dysfunction or cold extremities.\nCilnidipine 10mg\nAn N/L-type calcium channel blocker. Unlike conventional CCBs (e.g., amlodipine), cilnidipine blocks both L-type and N-type calcium channels. N-type blockade in the sympathetic nervous system reduces norepinephrine release, leading to smoother, more sustained BP reduction with significantly less ankle swelling — a common complaint with older CCBs.\nTogether, these agents provide additive antihypertensive effect while offsetting each other's side effects. Nebivolol reduces tachycardia that CCBs can sometimes cause, while cilnidipine's vasodilatory effect complements nebivolol's cardiac output reduction.\n\nIndications\nWho is Nebivolol 5 mg and Cilnidipine 10 mg prescribed for?\nThis combination is indicated for adults with hypertension who are not adequately controlled on monotherapy. It is especially suited for patients who have:\n\nCondition:\tWhy this combination is preferred\nHypertension with high heart rate\tNebivolol slows heart rate while cilnidipine controls peripheral resistance\nHypertension with diabetes\tMetabolically neutral; does not worsen glucose tolerance or lipid profile\nHypertension with CKD / proteinuria:\tCilnidipine's N-type blockade reduces glomerular pressure and protein leakage\nHypertension with coronary artery disease\tNebivolol provides cardioprotection and anti-anginal effect\nAmlodipine-related ankle edema\tSwitching to cilnidipine substantially reduces pedal edema due to N-type blockade\nUncontrolled BP on single antihypertensive\tCombination adds complementary mechanisms without increasing pill burden\n\nosage & Administration\nHow to take nebivolol 5 mg + cilnidipine 10mg\nThe standard recommended dose is one tablet once daily, preferably at the same time each day — most commonly in the morning with or without food. Your physician may adjust the dose based on your blood pressure response and individual tolerability.\n\nDo not crush, chew, or split the tablet unless your doctor advises. If you miss a dose, take it as soon as you remember, but skip it if it is almost time for the next dose. Never double up on doses. Swallowing the tablet whole with water is the preferred method of administration.\n\nDo not stop taking this medication abruptly. Sudden discontinuation of nebivolol (a beta-blocker) can trigger rebound hypertension or even angina in patients with underlying coronary disease. Always taper under medical guidance.\n\nCommon and serious side effects to know\nLike all medicines, nebivolol + cilnidipine can cause side effects, though not everyone experiences them. Knowing what to watch for helps you respond promptly.\n\nSide effect\tFrequency\tWhat to do\nHeadache, dizziness\tCommon (early phase)\tUsually resolves in 1–2 weeks; avoid sudden posture changes\nFatigue, tiredness\tCommon\tMonitor; often improves after dose adjustment\nAnkle swelling (pedal edema)\tLess common than with amlodipine\tReport if worsening; may require dose review\nBradycardia (slow heart rate)\tUncommon\tSeek medical advice if heart rate <50 bpm\nNausea, stomach upset\tUncommon\tTake after meals to minimise\nBronchospasm\tRare\tStop immediately; seek emergency care if breathlessness\nSevere hypotension\tRare\tEmergency — seek immediate medical attention.\n\nWhen should this combination not be used?\nImportant safety information\nThis tablet is contraindicated in: cardiogenic shock, decompensated heart failure, severe bradycardia (<60 bpm), sick sinus syndrome, second- or third-degree AV block (without pacemaker), severe hepatic impairment, known hypersensitivity to nebivolol or cilnidipine, pregnancy, and breastfeeding.\n\nUse with caution in patients with asthma or COPD (nebivolol has some beta-2 activity at higher doses), peripheral vascular disease, diabetes mellitus (may mask hypoglycemic symptoms), and in elderly patients prone to falls due to postural hypotension.\n\nAlways inform your doctor of all medications you are currently taking. Clinically significant interactions exist with other antihypertensives, NSAIDs, digoxin, antidiabetic agents, and CYP2D6 inhibitors (e.g., fluoxetine, paroxetine), which can raise nebivolol plasma levels.\n\n\n\n\n", "price": 305.0, "discountamount": 91.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2389, "imageuri": "https://productimages.withfloats.com/actual/69e9f8f745652456a0f3a497.png", "tileimageuri": "https://productimages.withfloats.com/tile/69e9f8f745652456a0f3a497.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2026-04-23T10:48:21.085Z", "updatedon": "2026-04-29T05:46:26.285Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM//nebivolol-5mg-cilnidipine-10mg/2389", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "NEBIVALVE CILNL 5/10", "category": "CARDIOLOGYRANGE", "tags": [ "nebivolol 5mg cilnidipine 10mg", "What is nebivolol 5mg and cilnidipine 10 mg used for?", "nebivolol cilnidipine", "nebivolol cilnidipine tab", "nebivolol cilnidipine uses", "nebivolol 5mg cilnidipine 10mg price", "nebivolol 5mg cilnidipine 10mg price in india", "nebivolol cilnidipine", "nebivolol 5mg cilnidipine 10mg" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false } ], "hasmoreitems": false, "isapirequest": false, "totalresults": 27, "query": null, "floatingpoint": null }