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{ "products": [ { "_id": "6911af10f122e2a45d230b07", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Sitagliptin 50 mg, Metformin Hydrochloride 1000 mg & Glimepirde 2 mg", "description": "Sitagliptin 50 mg, Metformin Hydrochloride 1000 mg, and Glimepiride 2 mg is a triple-combination oral anti-diabetic medication formulated to achieve optimal blood sugar control in adults with Type 2 Diabetes Mellitus (T2DM). This unique blend brings together three complementary agents — Sitagliptin (a DPP-4 inhibitor), Metformin (a biguanide), and Glimepiride (a sulfonylurea) — that work through distinct mechanisms to enhance glucose regulation, improve insulin sensitivity, and support overall metabolic balance.\n\nThis advanced combination therapy is prescribed when monotherapy or dual therapy fails to achieve adequate glycemic control. It helps reduce both fasting plasma glucose (FPG) and postprandial glucose (PPG) levels, promoting stable long-term glycemic management.\n\nUses of Sitagliptin + Metformin + Glimepiride\n\nThis fixed-dose combination is primarily indicated for the management of Type 2 Diabetes Mellitus in adults. It is especially beneficial for patients whose blood sugar levels remain uncontrolled despite treatment with Metformin and Glimepiride or Metformin and Sitagliptin alone.\n\nIts main objectives include:\n\nControlling elevated blood glucose levels in adults with Type 2 diabetes\n\nReducing the risk of diabetes-related complications such as neuropathy, nephropathy, and cardiovascular diseases\n\nSupporting better insulin utilization by the body\n\nComplementing diet, exercise, and lifestyle modification to maintain optimal glycemic balance\n\nMechanism of Action\n\nEach component of this combination plays a vital role in maintaining blood sugar control:\n\nSitagliptin (50 mg) – A Dipeptidyl Peptidase-4 (DPP-4) inhibitor that enhances the activity of incretin hormones. These hormones stimulate insulin release and suppress glucagon production when blood glucose levels rise, thereby improving post-meal glucose control.\n\nMetformin Hydrochloride (1000 mg) – A biguanide that lowers glucose production in the liver and increases the body’s sensitivity to insulin. It also decreases intestinal glucose absorption, making it an essential first-line therapy in diabetes management.\n\nGlimepiride (2 mg) – A sulfonylurea that stimulates pancreatic beta cells to release more insulin, especially when blood glucose levels are high. It works synergistically with Metformin and Sitagliptin for more effective glycemic control.\n\nKey Benefits\n\nTriple Mechanism for Superior Control:\nBy combining three potent agents, the medication addresses multiple pathways of glucose regulation—insulin secretion, insulin sensitivity, and hepatic glucose output—resulting in comprehensive and consistent control of blood sugar levels.\n\nEffective Glycemic Stability:\nThe combination helps maintain target HbA1c levels and reduces both fasting and post-meal glucose spikes without significant weight gain when used with proper diet and exercise.\n\nReduced Risk of Diabetic Complications:\nLong-term blood sugar control minimizes the risk of complications such as kidney disease, vision problems, nerve damage, and heart conditions associated with uncontrolled diabetes.\n\nConvenient Fixed-Dose Formulation:\nCombining three medications into a single tablet simplifies dosing schedules, improves patient adherence, and reduces pill burden, which is crucial for long-term treatment success.\n\nImproved Insulin Efficiency:\nEnhances the body's natural insulin response and glucose metabolism, allowing for smoother daily energy levels and reduced fatigue associated with hyperglycemia.\n\nPossible Side Effects\n\nWhile this combination is generally well tolerated, some patients may experience side effects, especially at the beginning of therapy. Common and rare side effects include:\n\nHypoglycemia (low blood sugar): More likely when meals are skipped or during excessive physical exertion. Symptoms include sweating, dizziness, and rapid heartbeat.\n\nGastrointestinal disturbances: Such as nausea, vomiting, diarrhea, abdominal discomfort, or loss of appetite (mostly due to Metformin).\n\nHeadache or Weakness: Usually mild and transient.\n\nAllergic reactions: Rarely, rash or itching may occur.\n\nLactic Acidosis (rare but serious): A potential complication of Metformin, particularly in patients with kidney impairment or excessive alcohol consumption.\n\nWeight gain: Mild weight gain may occur due to Glimepiride’s insulin-enhancing effect.\n\nPrecautions:\n\nRegular monitoring of blood sugar levels and kidney function is essential.\n\nAvoid alcohol and consult a doctor before using this medicine if you have liver or kidney disease.\n\nThe medication should not be used in patients with Type 1 diabetes or diabetic ketoacidosis.\n\nConclusion\n\nThe combination of Sitagliptin 50 mg, Metformin Hydrochloride 1000 mg, and Glimepiride 2 mg represents a powerful and balanced therapy for adults with Type 2 Diabetes Mellitus, especially those requiring triple-drug intervention to achieve desired glycemic control. Its multi-targeted approach ensures effective management of both fasting and postprandial glucose levels, thereby improving long-term metabolic health and reducing the risk of complications.", "price": 295.0, "discountamount": 89.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2197, "imageuri": "https://productimages.withfloats.com/actual/6911af137e4c90e1dc453884.png", "tileimageuri": "https://productimages.withfloats.com/tile/6911af137e4c90e1dc453884.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-11-10T09:23:28.795Z", "updatedon": "2025-11-10T09:27:11.643Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/sitagliptin-50-mg-metformin-hydrochloride-1000-mg-glimepirde-2-mg/2197", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "ST GLIPTIN GM 50+1000+2 ", "category": "DIABETIC RANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6908575f0c31b1295dc50d7e", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Ursodeoxycholic Acid 600 mg", "description": "Ursodeoxycholic Acid 600 mg is a clinically trusted and widely prescribed medication used in the management of liver and gallbladder disorders. Belonging to the class of bile acid derivatives, it plays a vital role in improving liver function and dissolving certain types of gallstones without surgery. This medicine is commonly prescribed to patients suffering from cholestatic liver diseases, such as primary biliary cholangitis (PBC), non-alcoholic fatty liver disease (NAFLD), and bile reflux gastritis.\n\nIn the Indian healthcare setting, Ursodeoxycholic Acid (also known as UDCA) has become a cornerstone therapy for liver protection. It is known not only for its effectiveness in improving bile flow but also for its anti-inflammatory, immunomodulatory, and cytoprotective properties. The 600 mg strength formulation provides an optimal dose for adult patients, ensuring consistent bile regulation and liver cell protection.\n\nProduced under stringent quality control by leading pharmaceutical companies like Steris Healthcare Pvt. Ltd., Ursodeoxycholic Acid 600 mg ensures purity, efficacy, and patient safety. This makes it a dependable choice for clinicians and patients managing chronic liver diseases in India.\n\nWhat is Ursodeoxycholic Acid?\n\nUrsodeoxycholic Acid (UDCA) is a naturally occurring bile acid that is present in small amounts in the human body. It is synthesized and used as a medication to treat liver and gallbladder conditions by altering bile composition and reducing the production of toxic bile acids.\n\nChemically, Ursodeoxycholic Acid is a hydrophilic bile acid, meaning it has a high affinity for water and helps replace harmful hydrophobic bile acids that can damage liver cells. It is known for its ability to protect hepatocytes (liver cells) from injury, enhance bile secretion, and dissolve cholesterol-based gallstones.\n\nBy reducing bile cholesterol saturation and promoting bile flow, UDCA helps maintain liver function, especially in conditions where bile flow is obstructed or impaired.\n\nMechanism of Action\n\nThe therapeutic action of Ursodeoxycholic Acid is multifaceted:\n\nBile Flow Regulation:\nUDCA improves bile secretion and reduces bile stasis (retention). This helps in clearing toxic bile acids from the liver, thereby preventing inflammation and fibrosis.\n\nCytoprotective Effect:\nIt stabilizes the hepatocyte (liver cell) membrane and reduces damage caused by bile acid-induced oxidative stress.\n\nImmunomodulatory Action:\nUrsodeoxycholic Acid reduces autoimmune destruction of bile ducts in diseases like primary biliary cholangitis by modulating immune response.\n\nCholesterol Reduction:\nUDCA decreases the cholesterol content of bile and suppresses hepatic cholesterol synthesis, leading to the gradual dissolution of cholesterol gallstones.\n\nAntifibrotic and Anti-inflammatory Role:\nBy reducing inflammation and fibrosis markers, UDCA helps slow the progression of chronic liver diseases.\n\nTherapeutic Uses of Ursodeoxycholic Acid 600 mg\n\nUrsodeoxycholic Acid 600 mg tablets are prescribed for a wide range of liver and gallbladder-related conditions. Below are the major medical indications:\n\n1. Primary Biliary Cholangitis (PBC):\n\nOne of the most common uses of UDCA is in treating primary biliary cholangitis, an autoimmune condition that causes slow, progressive destruction of bile ducts within the liver. Ursodeoxycholic Acid helps improve bile flow, reduce bilirubin levels, and delay the need for liver transplantation in many patients.\n\n2. Cholestatic Liver Diseases:\n\nIt is used to treat cholestatic conditions where bile secretion is impaired, such as:\n\nIntrahepatic cholestasis during pregnancy\n\nDrug-induced cholestasis\n\nChronic cholestatic hepatitis\n\nPost-surgical biliary obstruction\n\n3. Gallstone Dissolution (Cholesterol Gallstones):\n\nUrsodeoxycholic Acid 600 mg is effective in dissolving small, non-calcified cholesterol gallstones in patients who cannot undergo surgery. It works by reducing cholesterol saturation in bile, gradually breaking down gallstones over several months.\n\n4. Non-Alcoholic Fatty Liver Disease (NAFLD) and Non-Alcoholic Steatohepatitis (NASH):\n\nIn patients with fatty liver or metabolic liver disorders, UDCA helps improve liver enzyme levels and reduces oxidative stress, supporting better liver health.\n\n5. Bile Reflux Gastritis:\n\nUDCA is used to relieve symptoms caused by bile reflux into the stomach, such as epigastric pain, bloating, and nausea.\n\n6. Cystic Fibrosis-Related Liver Disease:\n\nIt can be used to improve bile flow and prevent hepatic complications in patients with cystic fibrosis.\n\n7. Post Liver Transplantation:\n\nUDCA is sometimes used as supportive therapy to prevent graft-related cholestasis and maintain optimal liver function after transplantation.\n\nKey Benefits of Ursodeoxycholic Acid 600 mg\n1. Promotes Healthy Liver Function\n\nUrsodeoxycholic Acid supports liver detoxification and enhances bile secretion, reducing bile stasis and protecting hepatocytes from toxic damage.\n\n2. Dissolves Cholesterol Gallstones Naturally\n\nUnlike surgical interventions, UDCA provides a non-invasive way to dissolve cholesterol gallstones, especially in patients unfit for surgery.\n\n3. Protects Liver Cells from Damage\n\nUDCA stabilizes the hepatocyte membrane and reduces cell injury caused by bile acids, alcohol, or medications.\n\n4. Reduces Inflammation and Fibrosis\n\nIts anti-inflammatory and antifibrotic properties help slow down the progression of chronic liver diseases.\n\n5. Regulates Cholesterol Levels\n\nUrsodeoxycholic Acid lowers bile cholesterol concentration, which helps maintain a balanced lipid profile and prevents gallstone formation.\n\n6. Supports Recovery in Liver Disorders\n\nIn patients with hepatitis, fatty liver, or cirrhosis, UDCA helps improve liver enzyme levels (ALT, AST, ALP), signaling better liver recovery.\n\n7. Improves Digestive Function\n\nBy improving bile flow, UDCA enhances fat digestion and reduces symptoms like bloating, nausea, and postprandial discomfort.\n\n8. Safe for Long-Term Use\n\nWhen prescribed under medical supervision, Ursodeoxycholic Acid 600 mg is well-tolerated and safe for prolonged treatment of chronic liver diseases.\n\nDosage and Administration\n\nRecommended Dose: The typical adult dose of Ursodeoxycholic Acid ranges between 8–12 mg per kilogram of body weight per day, which equals about 600 mg once or twice daily depending on the patient’s condition.\n\nFormulation: Tablet form (Ursodeoxycholic Acid 600 mg)\n\nMode of Administration: Oral\n\nTiming: It should be taken with meals to enhance absorption and reduce gastrointestinal side effects.\n\nTreatment Duration:\n\nFor gallstone dissolution, therapy may last for 6 months to 2 years.\n\nFor chronic liver conditions, treatment may be long-term or lifelong under physician guidance.\n\nImportant Note:\nThe dosage should be individualized based on body weight, liver function, and medical condition. Patients must not self-medicate and should take the medicine only as prescribed by a healthcare professional.\n\nPrecautions and Warnings\n\nBefore using Ursodeoxycholic Acid 600 mg, patients should consider the following precautions:\n\nMedical Supervision Required:\nAlways use this medicine under the guidance of a doctor, particularly if you have a history of severe liver or gallbladder disease.\n\nAvoid in Certain Gallstones:\nUDCA is not effective for calcified or pigment gallstones.\n\nPregnancy and Breastfeeding:\nWhile UDCA is considered relatively safe during pregnancy, it should only be used when prescribed by a physician. Minimal amounts may pass into breast milk.\n\nMonitor Liver Function:\nRegular liver function tests (LFTs) are advised during treatment to monitor therapeutic response and liver health.\n\nDrug Interactions:\nAvoid concurrent use with:\n\nAluminum-based antacids (reduce UDCA absorption)\n\nCholestyramine or Colestipol (interfere with bile acid absorption)\n\nCiclosporin or Estrogens (may alter bile composition)\n\nAlcohol Consumption:\nAlcohol can strain the liver and reduce the effectiveness of UDCA therapy. Patients should limit or avoid alcohol during treatment.\n\nGastrointestinal Disorders:\nUse with caution in patients with peptic ulcer, severe diarrhea, or gastrointestinal inflammation.\n\nPossible Side Effects of Ursodeoxycholic Acid 600 mg\n\nUrsodeoxycholic Acid is generally well-tolerated, but some patients may experience mild to moderate side effects. These are typically temporary and improve as the body adjusts to the medication.\n\nCommon Side Effects:\n\nDiarrhea or loose stools\n\nNausea and vomiting\n\nAbdominal discomfort\n\nIndigestion or bloating\n\nHeadache\n\nDizziness\n\nLess Common Side Effects:\n\nRash or itching (urticaria)\n\nIncreased liver enzymes (temporary)\n\nBack pain or joint pain\n\nCough or upper respiratory infection symptoms\n\nRare but Serious Side Effects:\n\nSevere right upper abdominal pain (may indicate gallstone complications)\n\nJaundice or dark urine (signs of liver stress)\n\nPersistent diarrhea or dehydration\n\nAllergic reaction (swelling, rash, or shortness of breath)\n\nNote:\nIf any of these side effects persist or worsen, it is important to inform your doctor immediately. Never stop or alter the dosage without consulting your healthcare provider.\n\nSafety in Special Populations\nPregnancy:\n\nUDCA is sometimes used to treat intrahepatic cholestasis of pregnancy (ICP) under strict medical supervision. While generally safe, dosage adjustment and monitoring are essential.\n\nLactation:\n\nIt is considered safe in breastfeeding mothers as minimal quantities are excreted into breast milk.\n\nElderly Patients:\n\nNo specific dosage adjustment is needed, but liver function should be monitored regularly.\n\nChildren:\n\nUrsodeoxycholic Acid can be prescribed in pediatric doses for liver-related disorders, particularly biliary atresia, under pediatric supervision.\n\nStorage and Handling\n\nStore in a cool, dry place below 25°C.\n\nProtect from moisture and direct sunlight.\n\nKeep out of reach of children.\n\nDo not use after the expiry date printed on the pack.\n\nClinical Efficacy and Research Insights\n\nClinical studies across India and globally have confirmed the efficacy of Ursodeoxycholic Acid in managing chronic liver and biliary diseases. Long-term use of UDCA has shown:\n\nImprovement in liver enzyme profiles (AST, ALT, ALP).\n\nReduction in bilirubin levels in cholestatic conditions.\n\nDelay in disease progression in primary biliary cholangitis.\n\nReduction in gallstone size and formation rate with consistent therapy.\n\nBetter quality of life scores among patients with chronic liver conditions.\n\nIts established safety profile and biochemical benefits make Ursodeoxycholic Acid a cornerstone therapy in hepatology.\n\nLifestyle and Dietary Recommendations During Treatment\n\nTo enhance the effectiveness of UDCA therapy and support liver health, patients are advised to:\n\nMaintain a Balanced Diet:\nInclude fresh fruits, vegetables, whole grains, and lean proteins. Avoid fatty, fried, and processed foods.\n\nStay Hydrated:\nDrink sufficient water to aid digestion and toxin elimination.\n\nLimit Alcohol and Caffeine:\nBoth can strain liver metabolism and interfere with medication effectiveness.\n\nExercise Regularly:\nModerate physical activity helps improve liver function and reduce fat accumulation.\n\nAvoid Self-Medication:\nConsult your doctor before using any over-the-counter supplements or herbal products.\n\nFrequently Asked Questions (FAQs)\n\nQ1. How long should Ursodeoxycholic Acid 600 mg be taken?\nThe duration depends on your condition. For gallstone dissolution, treatment may last 6–24 months. For chronic liver diseases, long-term therapy may be recommended.\n\nQ2. Can Ursodeoxycholic Acid cure liver disease completely?\nWhile it does not cure liver disease, UDCA can slow its progression, protect liver cells, and improve biochemical and clinical outcomes.\n\nQ3. Can I take Ursodeoxycholic Acid on an empty stomach?\nIt is best taken with food to enhance absorption and minimize stomach upset.\n\nQ4. Does it interact with other medications?\nYes. Antacids, cholesterol-binding resins, and estrogens may interfere with UDCA absorption or activity. Always inform your doctor about all medications you’re taking.\n\nQ5. How long does it take to see results?\nLiver function improvement can often be observed within a few weeks, but gallstone dissolution may take several months of consistent use.\n\nConclusion\n\nUrsodeoxycholic Acid 600 mg is a trusted and clinically validated therapy for various liver and gallbladder conditions. Its unique ability to enhance bile flow, protect liver cells, and dissolve cholesterol gallstones makes it an indispensable part of hepatology treatment protocols.", "price": 1385.0, "discountamount": 415.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2195, "imageuri": "https://productimages.withfloats.com/actual/69099314f017379146dfffdc.png", "tileimageuri": "https://productimages.withfloats.com/tile/69099314f017379146dfffdc.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-11-03T07:18:55.866Z", "updatedon": "2025-11-04T05:47:50.392Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/ursodeoxycholic-acid-600-mg/2195", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "Steris healthcare Pvt Ltd", "category": "GASTROLOGYRANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "68e7a474f3481c1f16d3b038", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Sitagliptin (50mg), Metformin Hydrochloride (500mg) & Glimepiride (2mg)", "description": "Sitagliptin 50mg, Metformin Hydrochloride 500mg & Glimepiride 2mg is a combination oral medication designed for the effective management of type 2 diabetes mellitus. This triple-action formula works synergistically to control blood glucose levels by addressing insulin resistance, enhancing insulin secretion, and regulating post-meal sugar spikes. Ideal for patients who require more than one mechanism to maintain stable blood sugar, this combination is often prescribed when monotherapy or dual therapy is insufficient.\n\nUses\n\nManagement of Type 2 Diabetes Mellitus in adults.\n\nHelps in controlling fasting and postprandial blood glucose levels.\n\nRecommended for patients whose blood sugar is not adequately controlled with a single antidiabetic medicine.\n\nCan be used as part of a comprehensive diabetes management plan, including diet and exercise.\n\nKey Benefits\n\nDual Mechanism Control:\n\nMetformin Hydrochloride reduces hepatic glucose production and improves insulin sensitivity.\n\nGlimepiride stimulates pancreatic beta cells to secrete more insulin.\n\nSitagliptin enhances incretin hormones, leading to better regulation of post-meal glucose levels.\n\nEffective Blood Sugar Management:\nHelps maintain optimal fasting and postprandial glucose levels, reducing the risk of diabetes-related complications.\n\nConvenient Combination Therapy:\nCombines three mechanisms in a single tablet, reducing the pill burden and improving patient compliance.\n\nSupports Overall Health:\nHelps prevent long-term complications such as neuropathy, nephropathy, retinopathy, and cardiovascular risks associated with diabetes.\n\nPossible Side Effects\n\nWhile generally well-tolerated, some patients may experience:\n\nGastrointestinal issues: nausea, vomiting, diarrhea, or abdominal discomfort (mainly from Metformin).\n\nHypoglycemia (low blood sugar): more likely due to Glimepiride; symptoms include dizziness, sweating, or shakiness.\n\nAllergic reactions: rash, itching, or swelling in rare cases.\n\nOther mild effects: headache, fatigue, or minor changes in taste.\n\nNote: Patients should always consult their doctor before starting this combination and report any unusual symptoms immediately.\n\nConclusion\n\nThe Sitagliptin, Metformin Hydrochloride & Glimepiride combination provides a powerful, multi-targeted approach to managing type 2 diabetes. By tackling high blood sugar from different angles, it supports better glucose control, enhances overall quality of life, and reduces the risk of diabetes-related complications. When used alongside proper diet, exercise, and medical guidance, this combination can be a cornerstone in effective diabetes management.", "price": 180.0, "discountamount": 54.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2185, "imageuri": "https://productimages.withfloats.com/actual/68e7a47b040520d37b5e6b34.png", "tileimageuri": "https://productimages.withfloats.com/tile/68e7a47b040520d37b5e6b34.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-10-09T12:03:00.012Z", "updatedon": "2025-10-09T12:03:00.012Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/sitagliptin-50mg-metformin-hydrochloride-500mg-glimepiride-2mg-/2185", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "ST GLIPTIN GM", "category": "", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "68822dd35b399ba6097ed11b", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "SEIZMET G 0.5 FORTE", "description": "SEIZMET G0.5 FORTE is a powerful oral antidiabetic medication formulated with a combination of glimepiride and metformin hydrochloride. This dual-action therapy is specifically designed for patients with type 2 diabetes mellitus who are unable to control their blood sugar levels with diet and exercise alone. The combination works in synergy to manage blood glucose effectively, reduce insulin resistance, and improve overall glycemic control.\n\nGlimepiride and metformin hydrochloride tablets are a combination medication used to treat type 2 diabetes. They work by helping the pancreas release more insulin and by reducing the amount of sugar produced by the liver, while also making the body more sensitive to insulin.\n\nWhat is SEIZMET G0.5 FORTE?\nSEIZMET G0.5 FORTE contains two active ingredients:\n\nGlimepiride (0.5 mg): A sulfonylurea class drug that stimulates the beta cells of the pancreas to release insulin.\n\nMetformin Hydrochloride: A biguanide that works primarily by suppressing hepatic glucose production and increasing insulin sensitivity in muscles.\n\nTogether, this combination addresses both insulin deficiency and resistance—two key factors in type 2 diabetes.\n\nUses of SEIZMET G0.5 FORTE:\n\nEffective in managing type 2 diabetes mellitus\n\nHelps in reducing fasting and postprandial blood glucose levels\n\nUsed as monotherapy or in combination with other antidiabetic agents\n\nReduces the risk of diabetic complications such as nephropathy, retinopathy, and cardiovascular disease\n\nSide Effects of SEIZMET G0.5 FORTE:\nLike all medications, glimepiride and metformin hydrochloride tablets may cause side effects in some patients. Common side effects include:\n\nNausea or vomiting\n\nDiarrhea\n\nHypoglycemia (low blood sugar)\n\nHeadache\n\nDizziness\n\nMetallic taste in the mouth\n\nAbdominal discomfort\n\nIn rare cases, it may cause lactic acidosis, a serious condition related to metformin accumulation.\n\nPrecautions Before Using SEIZMET G0.5 FORTE:\n\nAlways take the medication exactly as prescribed by your doctor.\n\nInform your physician if you have a history of liver or kidney disorders, heart disease, or alcohol abuse.\n\nAvoid excessive alcohol consumption while on this medication as it increases the risk of lactic acidosis.\n\nNot recommended for patients with type 1 diabetes or diabetic ketoacidosis.\n\nRegularly monitor your blood sugar and kidney function.\n\nThis medicine should be used during pregnancy only if absolutely necessary and under medical supervision.\n\nDrug Interactions: What Drugs Interact with SEIZMET G0.5 FORTE?\nCertain medications can interact with glimepiride and metformin, affecting their efficacy or increasing the risk of side effects. These include:\n\nBeta-blockers (e.g., propranolol) – may mask hypoglycemia symptoms\n\nDiuretics – may impair blood sugar control\n\nACE inhibitors – may increase the blood glucose-lowering effect\n\nCorticosteroids – may reduce the effectiveness of the medication\n\nAntipsychotics (e.g., olanzapine)\n\nAlcohol – increases the risk of lactic acidosis\n\nCimetidine – may raise metformin levels in the body\n\nAlways inform your healthcare provider about all medications, supplements, or herbal products you are taking.\n\nConclusion:\nSEIZMET G0.5 FORTE is a trusted, effective choice for managing type 2 diabetes, offering the combined benefits of glimepiride and metformin hydrochloride tablets. With dual mechanisms—enhancing insulin secretion and improving insulin sensitivity—it delivers comprehensive glycemic control. When taken as directed and with regular monitoring, SEIZMET G0.5 FORTE can be a valuable part of a diabetic patient’s treatment regimen, contributing to a healthier, more balanced life.\n\nFor best results, pair this medication with a proper diet, regular physical activity, and periodic blood glucose testing. Always consult your healthcare provider for personalized advice.", "price": 125.0, "discountamount": 38.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2151, "imageuri": "https://productimages.withfloats.com/actual/68822dd8296c4d19d55e8535.png", "tileimageuri": "https://productimages.withfloats.com/tile/68822dd8296c4d19d55e8535.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-07-24T12:57:55.385Z", "updatedon": "2025-07-24T12:57:55.385Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/seizmet-g-0-5-forte/2151", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "glimepiride and metformin hydrochloride tablets", "category": "DIABETIC RANGE", "tags": [ "glimepiride and metformin hydrochloride tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "681c5e9e5a26e4010ea42029", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "ST-GLIPTIN M 100/ 1000", "description": "ST-GLIPTIN M 100/1000 is an advanced oral antidiabetic medication designed for the effective management of Type 2 Diabetes Mellitus. This powerful combination of Sitagliptin (100 mg) and Metformin Hydrochloride (1000 mg) offers dual action in controlling elevated blood glucose levels, especially in patients who do not respond adequately to metformin or sitagliptin alone. It is intended for adults and is generally used in conjunction with diet and exercise to enhance glycemic control.\n\nKey Ingredients\nSitagliptin (100 mg)\nSitagliptin is a DPP-4 (Dipeptidyl Peptidase-4) inhibitor that increases the levels of incretin hormones, which help regulate blood sugar by increasing insulin release and decreasing glucagon levels.\n\nMetformin Hydrochloride (1000 mg)\nMetformin belongs to the biguanide class of antidiabetics. It works by reducing the amount of sugar produced by the liver and improves the body’s sensitivity to insulin, facilitating better glucose utilization.\n\nKey Benefits\nHelps reduce both fasting and postprandial (after-meal) blood glucose levels effectively\nImproves overall glycemic control in patients with Type 2 diabetes\nCombines two different mechanisms of action for better diabetes management\nMinimizes the risk of hypoglycemia compared to other antidiabetic therapies\nMay support weight neutrality or slight weight loss in diabetic individuals\n\nHow Does It Work?\nST-GLIPTIN M 100/1000 works through a synergistic mechanism by combining two effective antidiabetic agents:\n\nSitagliptin enhances the levels of incretin hormones, which help the pancreas produce more insulin and reduce the secretion of glucagon, especially when blood sugar is high.\nMetformin reduces hepatic glucose production and increases insulin sensitivity, which helps the body use glucose more efficiently.\nTogether, these agents provide comprehensive blood sugar control by addressing multiple physiological pathways involved in glucose metabolism.\n\nDirections for Use\nTake ST-GLIPTIN M 100/1000 exactly as prescribed by your physician.\nIt is typically taken once or twice daily with meals to reduce gastrointestinal side effects and optimize absorption.\nSwallow the tablet whole with water. Do not crush or chew the tablet.\nMaintain a balanced diet and follow an active lifestyle for best results.\nRegular blood sugar monitoring is essential to assess effectiveness and make any necessary dosage adjustments.\n\nSide Effects\nCommon side effects may include nausea, diarrhea, stomach upset, or headache.\nSome individuals may experience respiratory tract infections, sore throat, or a runny nose.\nLactic acidosis is a rare but serious side effect associated with high-dose metformin—seek immediate medical attention if symptoms like unusual fatigue, muscle pain, difficulty breathing, or abdominal discomfort occur.\nAllergic reactions such as rash, itching, or swelling are uncommon but possible.\nAlways inform your doctor of any persistent or bothersome side effects for timely intervention.", "price": 225.0, "discountamount": 68.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "1001000 works", "100 1000stgliptin", "work stgliptin", "balanced diet", "tablet maintain", "diabetic individuals", "sitagliptin 100 mg", "timely intervention", "rash itching", "medical attention", "highdose metforminseek", "assess effectiveness", "active lifestyle", "pancreas produce", "synergistic mechanism", "antidiabetic therapies", "hypoglycemia compared", "glycemic control", "biguanide class", "incretin hormones", "respond adequately", "powerful combination", "insulin facilitating", "sugar produced", "side effect", "bodys sensitivity", "effective management", "blood sugar", "increases insulin sensitivity", "regulate blood sugar", "glucose metabolism directions", "increasing insulin release", "bothersome side effects", "diabetes management minimizes", "optimize absorption swallow", "slight weight loss", "support weight neutrality" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2107, "imageuri": "https://productimages.withfloats.com/actual/681c5e9f5e6dd8f19a0309c3.png", "tileimageuri": "https://productimages.withfloats.com/tile/681c5e9f5e6dd8f19a0309c3.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-05-08T07:34:54.516Z", "updatedon": "2025-05-08T07:35:36.782Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/st-gliptin-m-100-1000/2107", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "sitagliptin and metformin hydrochloride tablets", "category": "DIABETIC RANGE", "tags": [ "Sitagliptin and Metformin hydrochloride tablets Uses in Hindi", "sitagliptin and metformin hydrochloride tablets 50/1000 uses in hindi", "sitagliptin and metformin hydrochloride tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "67c5887fcd301704c9b6528a", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Repaglinide 0.5mg", "description": "RAPIGLINIDE 0.5 contains Repaglinide 0.5 mg, a medication used in the treatment of Type 2 diabetes mellitus. It belongs to a class of drugs known as meglitinides, which help control blood sugar levels by stimulating insulin production from the pancreas. RAPIGLINIDE is commonly prescribed to individuals who are unable to maintain optimal blood glucose levels through diet and exercise alone. It can be used alone or in combination with other oral diabetes medications to help manage blood sugar levels effectively.\n\n \nKey Benefits:\n \n Effective Blood Sugar Control – Helps lower postprandial blood glucose levels, effectively managing blood sugar spikes after meals.\n Rapid Action – Starts working quickly, offering fast relief from elevated blood sugar levels.\n Flexible Dosing – Can be taken before meals, giving flexibility in meal planning and diabetes management.\n Helps Prevent Complications of Diabetes – By controlling blood sugar levels, it helps in reducing the risk of complications associated with diabetes, such as nerve damage, heart disease, and kidney issues.\n Used Alone or with Other Diabetes Medications – RAPIGLINIDE 0.5 can be combined with other oral diabetes drugs for better blood sugar management.\n\n \nHow Does It Work?\n \n\nRepaglinide 0.5 mg works by stimulating the beta cells in the pancreas to secrete insulin when blood sugar levels rise after meals. The medication acts quickly, allowing the body to use glucose more effectively and preventing high blood sugar spikes. Unlike other long-acting insulin medications, Repaglinide acts quickly but for a short duration, making it suitable for controlling blood sugar right after eating. It helps in maintaining optimal postprandial glucose levels, which is crucial for the management of Type 2 diabetes.\n\n \nDirections for Use:\n \n\nTake RAPIGLINIDE 0.5 exactly as prescribed by your doctor.\nThe typical dosage is 0.5 mg to 2 mg taken before meals, 2 to 3 times daily.\nSwallow the tablet whole with water.\nDo not take more than the prescribed dose, and never skip doses.\nIf you miss a dose, take it as soon as you remember before the next meal. If it's almost time for your next meal, skip the missed dose—do not double the dose.\n \nSide Effects:\n \n\nWhile RAPIGLINIDE 0.5 is generally well-tolerated, some people may experience:\n\nHypoglycemia (low blood sugar): Symptoms include dizziness, sweating, shaking, confusion, and headaches.\nNausea or diarrhea\nWeight gain (in some cases)\nHeadache or dizziness\nRash or itching (rare)\nAbdominal discomfort\nIf you experience any signs of severe hypoglycemia (such as confusion, blurred vision, or seizures), or severe allergic reactions (such as difficulty breathing, swelling of the face or throat), seek immediate medical attention.", "price": 217.0, "discountamount": 66.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "2 mg", "05 mg", "rapiglinide 05", "meals 2", "pancreas rapiglinide", "repaglinide 05 mg", "meal skip", "prescribed dose", "meal planning", "commonly prescribed", "medical attention", "throat seek", "dizziness rash", "cases headache", "headaches nausea", "generally welltolerated", "missed dosedo", "skip doses", "typical dosage", "beta cells", "kidney issues", "repaglinide 05mgrapiglinide 05", "severe hypoglycemia", "secrete insulin", "oral diabetes drugs", "stimulating insulin production", "meals giving flexibility", "dose side effects", "blood sugar management", "oral diabetes medications", "severe allergic reactions", "difficulty breathing swelling", "confusion blurred vision", "diarrhea weight gain", "controlling blood sugar", "short duration making" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2063, "imageuri": "https://productimages.withfloats.com/actual/67c588a2587befa5fb853a41.png", "tileimageuri": "https://productimages.withfloats.com/tile/67c588a2587befa5fb853a41.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-03-03T10:46:23.834Z", "updatedon": "2025-03-03T10:46:56.222Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/repaglinide-0-5mg/2063", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "RAPIGLINIDE 0.5", "category": "DIABETIC RANGE", "tags": [ "Repaglinide 0.5 Mg Tablet Uses in Hindi", "Repaglinide 0.5 mg tablet uses", "Repaglinide 0.5 mg brand name", "Repaglinide brand name", "Repaglinide side effects 0.5 mg" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "674b0a7ee34075b8291b14f1", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Glimepiride 0.5 mg, Voglibose 0.2 mg & Metformin Hydrochloride (SR) 500 mg Tablets", "description": "Diabetes management often requires a multifaceted approach to address the complexities of glucose regulation. Glimiteris Trio 0.5/0.2/500 offers a synergistic combination of three proven antidiabetic agents. This tablet not only targets fasting and postprandial blood glucose but also improves the body’s insulin utilization, ensuring better glycemic control and reducing the risk of complications associated with diabetes.\n\n \nKey Benefits:\nEffective Blood Sugar Management: Works on multiple pathways to control both fasting and postprandial blood glucose levels.\nReduces Insulin Resistance: Enhances the body's response to insulin, improving its efficacy.\nMinimizes Post-Meal Glucose Spikes: Voglibose slows carbohydrate digestion and absorption, keeping postprandial glucose in check.\nImproves Long-Term Glycemic Control: Helps in achieving and maintaining stable HbA1c levels.\nSustained Release Formula: Metformin’s SR formulation ensures prolonged action, reducing the need for frequent dosing.\nComprehensive Diabetes Management: Prevents complications like neuropathy, retinopathy, and cardiovascular issues associated with diabetes.\nHow Does It Work?\nGlimepiride: Stimulates the pancreas to release insulin, directly lowering blood glucose levels.\nVoglibose: Inhibits enzymes that break down carbohydrates into glucose, thereby delaying glucose absorption and controlling post-meal spikes.\nMetformin Hydrochloride SR: Decreases hepatic glucose production, enhances peripheral glucose uptake, and improves insulin sensitivity, ensuring balanced glucose levels throughout the day.\nTogether, these three ingredients address the multifaceted nature of type 2 diabetes, providing a holistic solution for effective blood sugar control.\n\nDirections for Use:\nDosage: Take one tablet as prescribed by your healthcare professional, usually once or twice daily with meals.\nSwallow Whole: Do not crush or chew the tablet; it is designed for sustained release.\nTiming: Preferably consume with a meal to reduce gastrointestinal discomfort and optimize efficacy.\nFollow Medical Advice: Stick to the prescribed dosage and schedule for optimal results.\nAlways consult your doctor before starting or adjusting your dosage.\n\nSide Effects:\nWhile Glimiteris Trio 0.5/0.2/500 is generally well-tolerated, some individuals may experience side effects, including:\n\nCommon Side Effects:\n\nNausea, vomiting, or diarrhea\nStomach discomfort or flatulence\nMild hypoglycemia (low blood sugar levels)\nRare but Serious Side Effects:\n\nSevere hypoglycemia\nLactic acidosis (from Metformin)\nAllergic reactions such as rash or itching\n\n", "price": 153.0, "discountamount": 46.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "prescribed dosage", "ingredients address", "glycemic control", "targets fasting", "generally welltolerated", "glimiteris trio 0502500", "optimal results", "meals swallow", "healthcare professional", "holistic solution", "multifaceted nature", "cardiovascular issues", "neuropathy retinopathy", "insulin improving", "bodys response", "multiple pathways", "synergistic combination", "multifaceted approach", "dosage side effects", "delaying glucose absorption", "postprandial blood glucose", "metformin allergic reactions", "diarrhea stomach discomfort", "experience side effects", "reduce gastrointestinal discomfort", "work glimepiride stimulates", "proven antidiabetic agents" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2016, "imageuri": "https://productimages.withfloats.com/actual/674b0a80ec7bb8b7dcae8a8a.png", "tileimageuri": "https://productimages.withfloats.com/tile/674b0a80ec7bb8b7dcae8a8a.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2024-11-30T12:52:14.799Z", "updatedon": "2024-11-30T12:52:14.799Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/glimepiride-0-5-mg-voglibose-0-2-mg-metformin-hydrochloride-sr-500-mg-tablets/2016", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "GLIMITERIS TRIO 0.5/0.2/500 ", "category": "DIABETIC RANGE", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "66d83ad4ed345980e0fca5c5", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Voglibose (0.3mg), Metformin (500mg), Gliclazide (80mg)", "description": "GLICLAGLAZE TRIO 0.3 \nVoglibose (0.3mg), Metformin (500mg), Gliclazide (80mg)\nGLICLAGLAZE TRIO 0.3 is a powerful combination medication designed to manage and control type 2 diabetes. It is formulated with three active ingredients: Voglibose, Metformin, and Gliclazide. This unique combination helps to regulate blood sugar levels effectively, providing a comprehensive approach to diabetes management. GLICLAGLAZE TRIO 0.3 is particularly useful for patients who require a multifaceted treatment strategy to keep their blood glucose levels in check.\n\n \n\nKey Benefits:\n \n\nEffective Blood Sugar Control: The combination of Voglibose, Metformin, and Gliclazide offers a synergistic effect, providing comprehensive control over blood sugar levels.\nPrevents Post-Meal Sugar Spikes: Voglibose helps in delaying glucose absorption, reducing the risk of hyperglycemia after meals.\nImproved Insulin Sensitivity: Metformin enhances the body's response to insulin, ensuring better glucose management.\nEnhanced Insulin Secretion: Gliclazide helps in stimulating insulin release from the pancreas, making it easier to maintain stable blood sugar levels.\n \n\nHow Does It Work?\n \n\nGLICLAGLAZE TRIO 0.3 works through a multi-pronged approach to manage diabetes. Voglibose slows down the absorption of carbohydrates in the gut, which helps to prevent rapid increases in blood sugar levels after meals. Metformin reduces the liver's glucose production and improves insulin sensitivity, ensuring better glucose uptake and utilization. Gliclazide stimulates the pancreas to release insulin, aiding in the reduction of blood glucose levels.\n\n \n\nDirections for Use:\n \n\nTake GLICLAGLAZE TRIO 0.3 as prescribed by your healthcare provider. It is typically taken before meals to maximize its effectiveness in controlling postprandial blood sugar spikes. Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. Your doctor will determine the appropriate dosage and frequency based on your individual health needs.\n\n \n\nSide Effects:\n \n\nLike all medications, GLICLAGLAZE TRIO 0.3 may cause some side effects. Common side effects include gastrointestinal disturbances such as nausea, diarrhea, and abdominal pain. Hypoglycemia (low blood sugar) may occur, especially if you skip meals or engage in intense physical activity. Other possible side effects include dizziness, headache, and fatigue. If you experience any severe side effects or allergic reactions, seek medical attention immediately.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n", "price": 185.0, "discountamount": 56.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 7, "_keywords": [ "Key Benefits", "abdominal pain", "glucose uptake", "type 2 diabetes", "rapid increases", "insulin release", "low blood sugar", "GLICLAGLAZE TRIO", "medical attention", "glucose absorption", "allergic reactions", "appropriate dosage", "synergistic effect", "unique combination", "glucose production", "glucose management", "diabetes management", "healthcare provider", "severe side effects", "Common side effects", "blood glucose levels", "comprehensive control", "multi-pronged approach", "comprehensive approach", "Post-Meal Sugar Spikes", "individual health needs", "three active ingredients", "intense physical activity", "stable blood sugar levels", "Enhanced Insulin Secretion", "Other possible side effects", "Improved Insulin Sensitivity", "gastrointestinal disturbances", "Effective Blood Sugar Control", "powerful combination medication", "multifaceted treatment strategy", "postprandial blood sugar spikes" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 1962, "imageuri": "https://productimages.withfloats.com/actual/66d83afac7293b3595ec4ea6.jpeg", "tileimageuri": "https://productimages.withfloats.com/tile/66d83afac7293b3595ec4ea6.jpeg", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2024-09-04T10:47:48.369Z", "updatedon": "2024-09-04T10:47:48.369Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/voglibose-0-3mg-metformin-500mg-gliclazide-80mg-/1962", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "GLICLAGLAZE TRIO 0.3 ", "category": "DIABETIC RANGE", "tags": null, "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": "", "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.001, "isnotforsale": false }, { "_id": "668e8611b9f7300708fe1240", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "TRIOGLIMITERIS 1/0.2 ", "description": "TRIOGLIMITERIS 1/0.2 \nVoglibose 0.2 mg, Glimepiride 1 mg & Metformin Hydrochloride 500 mg\nIntroduction\n\nTRIOGLIMITERIS 1/0.2 is a combination medication containing Voglibose, Glimepiride, and Metformin Hydrochloride. It is primarily used in the management of type 2 diabetes mellitus to improve glycemic control through different mechanisms of action targeting glucose metabolism.\n\nComposition\n\nVoglibose (0.2 mg): An alpha-glucosidase inhibitor that delays the digestion of carbohydrates in the intestine, thereby reducing postprandial blood glucose levels.\nGlimepiride (1 mg): A sulfonylurea derivative that stimulates insulin release from pancreatic beta cells, enhancing glucose uptake in peripheral tissues.\nMetformin Hydrochloride (500 mg): A biguanide that decreases hepatic glucose production, improves insulin sensitivity in peripheral tissues, and reduces intestinal glucose absorption.\nMechanism of Action\n\nTRIOGLIMITERIS 1/0.2 combines the actions of its components to achieve optimal glycemic control:\n\nVoglibose: Inhibits alpha-glucosidase enzymes in the intestine, delaying carbohydrate digestion and reducing the absorption of glucose after meals.\nGlimepiride: Stimulates insulin secretion from pancreatic beta cells in a glucose-dependent manner, thereby lowering blood glucose levels.\nMetformin Hydrochloride: Decreases hepatic glucose production through suppression of gluconeogenesis and enhances peripheral glucose uptake and utilization by improving insulin sensitivity.\nIndications\n\nTRIOGLIMITERIS 1/0.2 is indicated for:\n\nType 2 Diabetes Mellitus: Used to improve glycemic control in adults when diet, exercise, and monotherapy with metformin or sulfonylureas alone are not sufficient.\nDosage and Administration\n\nThe typical dosage of TRIOGLIMITERIS 1/0.2 is one tablet taken orally with meals, usually once or twice daily.\nDosage adjustments may be required based on individual patient response, blood glucose levels, and renal function.\nIt is essential to adhere to the prescribed dosage regimen to achieve optimal therapeutic outcomes.\nSide Effects\n\nCommon side effects of TRIOGLIMITERIS 1/0.2 may include:\n\nHypoglycemia (especially when used in combination with insulin or other antidiabetic medications)\nGastrointestinal disturbances (such as nausea, vomiting, diarrhea, or abdominal discomfort)\nWeight gain (mainly associated with sulfonylureas)\nMore severe side effects can include:\n\nAllergic reactions (rash, itching, swelling)\nLactic acidosis (rare but serious adverse effect associated with metformin use)\nHepatic dysfunction (monitor liver function tests periodically)\nPrecautions\n\nUse with caution in patients with renal impairment, hepatic dysfunction, or other significant medical conditions that may affect drug metabolism or excretion.\nRegular monitoring of blood glucose levels, renal function, and liver function is recommended during treatment with TRIOGLIMITERIS 1/0.2.\nAvoid use in patients with type 1 diabetes mellitus or diabetic ketoacidosis.\nDrug Interactions\n\nTRIOGLIMITERIS 1/0.2 may interact with other medications affecting blood glucose levels, such as insulin, other oral antidiabetic agents, or drugs that affect renal function or hepatic metabolism. Close monitoring and dose adjustments may be necessary.\nConclusion\n\nTRIOGLIMITERIS 1/0.2 provides a comprehensive approach to managing type 2 diabetes mellitus by combining Voglibose, Glimepiride, and Metformin Hydrochloride. This combination targets different aspects of glucose metabolism, enhancing insulin secretion, reducing hepatic glucose production, and delaying carbohydrate absorption in the intestine. Proper dosage, administration, and monitoring for side effects are essential to achieve and maintain optimal glycemic control in diabetic patients using TRIOGLIMITERIS 1/0.2. 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