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"description": "CARDULES ISMN SR 40 is a sustained-release tablet formulated with Isosorbide Mononitrate (40 mg), a powerful nitrate-based compound used primarily in the prevention and long-term management of angina pectoris (chest pain caused by heart disease). This medication works by relaxing and widening blood vessels, allowing for improved blood flow to the heart, reducing its workload, and preventing episodes of chest pain. It is typically prescribed for patients with chronic stable angina and forms part of a long-term treatment plan for certain heart conditions.\n\n\nKey Benefits:\n\n\nHelps prevent and manage angina (chest pain) in patients with coronary artery disease.\n\nImproves blood flow to the heart muscles, reducing the risk of cardiac ischemia.\n\nDecreases the oxygen demand on the heart by reducing preload and afterload.\n\nOffers long-lasting relief with a sustained-release action for convenience and steady plasma levels.\n\nReduces the frequency of anginal attacks, enhancing quality of life and exercise tolerance.\n\n\nHow Does It Work?\n\n\nIsosorbide Mononitrate, the active ingredient in CARDULES ISMN SR 40, is converted into nitric oxide in the body. Nitric oxide activates guanylate cyclase, leading to increased levels of cyclic GMP (cGMP). This compound causes relaxation of vascular smooth muscles, primarily in the veins and arteries, resulting in vasodilation. As a result, blood flows more freely to the heart with reduced pressure, decreasing the heart's workload and helping to prevent episodes of angina. The sustained-release formulation ensures a prolonged therapeutic effect, minimizing fluctuations in drug levels throughout the day.\n\nDirections for Use\nTake CARDULES ISMN SR 40 exactly as prescribed by your doctor.\n\nSwallow the tablet whole with a glass of water, preferably at the same time each day.\n\nDo not crush, chew, or break the tablet as it is designed for slow release over time.\n\nIt is typically taken once daily, but the dosage may vary depending on individual medical conditions.\n\nAvoid taking the tablet on an empty stomach unless advised by your healthcare provider.\n\nDo not suddenly stop taking the medication without consulting your doctor.\n\n\nSide Effects:\n\n\nLike all medications, CARDULES ISMN SR 40 may cause some side effects, although not everyone experiences them. Common side effects include:\n\nHeadache (especially at the beginning of treatment).\n\nDizziness or lightheadedness.\n\nFlushing of the skin.\n\nNausea or vomiting.\n\nFatigue.\n\nLow blood pressure (hypotension).\n\nIn rare cases, severe allergic reactions or fainting may occur. Contact your healthcare provider immediately if you experience chest pain that doesn't improve, irregular heartbeat, or signs of an allergic reaction like rash, itching, or swelling.",
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"description": "TRIMETAZ CR 80 \nTrimetazidine (80mg)\nIntroduction\nTRIMETAZ CR 80 is a medication containing Trimetazidine hydrochloride, formulated to treat angina pectoris and certain other cardiovascular conditions. It is known for its metabolic effects on the heart muscle, improving myocardial efficiency and reducing symptoms associated with ischemic heart disease.\n\nComposition\n\nTrimetazidine (80mg): The active ingredient, Trimetazidine, acts as a cellular metabolic agent that enhances myocardial glucose utilization and improves energy production in the heart muscle.\nMechanism of Action\nTrimetazidine exerts its therapeutic effects through several mechanisms:\n\nMetabolic Regulation: Shifts myocardial energy substrate utilization from fatty acids toward glucose oxidation, which is more efficient and requires less oxygen.\nAnti-ischemic Effect: Protects the heart against ischemic damage by preserving cellular energy metabolism and reducing oxidative stress.\nImprovement in Symptomatology: Reduces angina symptoms such as chest pain, shortness of breath, and exercise intolerance by enhancing myocardial function.\nIndications\nTRIMETAZ CR 80 is indicated for:\n\nChronic Stable Angina Pectoris: Used as adjunctive therapy in patients who are inadequately controlled with other anti-anginal medications.\nIschemic Heart Disease: Helps improve myocardial function and reduce symptoms associated with coronary artery disease.\nDosage and Administration\n\nThe usual dosage of TRIMETAZ CR 80 is one tablet (80mg) taken orally twice daily, preferably with meals.\nThe extended-release formulation ensures sustained therapeutic levels of Trimetazidine throughout the day.\nDosage adjustments may be necessary based on individual patient response and tolerance.\nSide Effects\nCommon side effects may include:\n\nHeadache\nDizziness\nNausea\nGastrointestinal disturbances (such as abdominal pain or diarrhea)\nSevere side effects are rare but may include:\n\nAllergic reactions (rash, itching, swelling)\nExtrapyramidal symptoms (involuntary movements)\nHepatic dysfunction (monitor liver function tests periodically)\nPrecautions\n\nUse with caution in patients with severe renal impairment or hepatic dysfunction, as Trimetazidine metabolism may be altered.\nMonitor patients for signs of extrapyramidal symptoms, especially in patients with Parkinson's disease or other movement disorders.\nAvoid abrupt discontinuation of Trimetazidine, as it may worsen angina symptoms.\nDrug Interactions\n\nTrimetazidine may interact with other medications that affect myocardial metabolism or cardiac function, including beta-blockers and calcium channel blockers. Close monitoring is recommended when used concomitantly.\nConclusion\nTRIMETAZ CR 80 is a valuable therapeutic option for managing chronic stable angina pectoris and ischemic heart disease by improving myocardial efficiency and reducing symptoms associated with cardiac ischemia. Its mechanism of action, focusing on metabolic modulation and anti-ischemic effects, makes it an effective adjunctive therapy in patients with inadequate symptom control on standard anti-anginal medications. Proper dosage, administration, and monitoring for side effects are essential to ensure safe and effective use of TRIMETAZ CR 80 in cardiovascular patients. Consultation with a healthcare provider is recommended for personalized treatment plans and management of cardiac conditions with TRIMETAZ CR 80.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n\n",
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"description": "TENELIGOLD PIO 20/15 \nTeneligliptin & Pioglitazone\nIntroduction\nTENELIGOLD PIO 20/15 combines two antidiabetic medications, Teneligliptin and Pioglitazone, in a single formulation. This combination is designed to manage type 2 diabetes mellitus by targeting different aspects of glucose metabolism, thereby improving glycemic control in patients who are inadequately controlled with monotherapy or require dual therapy.\n\nComposition\n\nTeneligliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucagon release, thereby lowering blood glucose levels.\nPioglitazone: A thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues (muscle and adipose tissue) and reduces hepatic glucose production.\nMechanism of Action\n\nTeneligliptin: Inhibits the degradation of incretin hormones (GLP-1 and GIP), which play a key role in glucose-dependent insulin secretion and suppression of glucagon secretion.\nPioglitazone: Activates peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to improved insulin sensitivity, enhanced glucose uptake in peripheral tissues, and reduced hepatic glucose production.\nIndications\nTENELIGOLD PIO 20/15 is indicated for:\n\nType 2 Diabetes Mellitus: Used to improve glycemic control in adults who are inadequately controlled with diet and exercise alone or with other antidiabetic medications.\nDosage and Administration\n\nThe typical dosage is one tablet of TENELIGOLD PIO 20/15 taken orally once daily, preferably with meals.\nDosage adjustments may be necessary based on individual patient response and tolerability.\nIt is important to adhere to the prescribed dosage regimen to achieve optimal glycemic control.\nSide Effects\nCommon side effects may include:\n\nHypoglycemia (especially when used in combination with insulin or sulfonylureas)\nEdema (fluid retention)\nWeight gain\nHeadache\nNasopharyngitis (common cold)\nMore severe side effects can include:\n\nHeart failure (especially in patients with pre-existing cardiovascular disease)\nHepatic dysfunction (monitor liver function tests periodically)\nBone fractures (especially in women)\nPrecautions\n\nHeart Failure: Use with caution in patients with a history of heart failure or other cardiovascular diseases.\nBladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; therefore, it should be used cautiously in patients with a history of bladder cancer or with risk factors.\nLiver Function: Monitor liver function tests before starting treatment and periodically thereafter, as Pioglitazone may cause hepatic dysfunction.\nPregnancy and Lactation: Use during pregnancy and lactation should be avoided unless the potential benefits outweigh the risks.\nDrug Interactions\n\nInsulin/Sulfonylureas: Increased risk of hypoglycemia when used concomitantly with insulin or sulfonylureas.\nGemfibrozil: May increase Pioglitazone levels, requiring dose adjustment.\nCYP2C8 Inhibitors (e.g., Gemfibrozil): May increase Pioglitazone concentrations, necessitating monitoring for adverse effects.\nConclusion\nTENELIGOLD PIO 20/15 offers a dual-action approach to managing type 2 diabetes mellitus by combining Teneligliptin and Pioglitazone. This combination helps improve glycemic control through different mechanisms: enhancing insulin secretion and sensitivity. It is crucial to use this medication under the guidance of a healthcare professional to optimize treatment outcomes while minimizing the risk of side effects. Regular monitoring for efficacy and safety parameters, including blood glucose levels and potential adverse effects, is essential for managing diabetes effectively with TENELIGOLD PIO 20/15.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n\n",
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"description": "CILOSTAZONE 100 \nCilostazol (100mg)\nIntroduction\nCILOSTAZONE 100 contains Cilostazol (100 mg), a potent medication used to treat the symptoms of intermittent claudication in individuals with peripheral artery disease (PAD). By improving blood flow and reducing pain during physical activity, Cilostazol enables patients to walk longer distances and engage more comfortably in daily activities.\n\nKey Ingredient and Its Benefits\nCilostazol (100 mg)\nImproved Blood Flow: Cilostazol works by inhibiting phosphodiesterase III, leading to an increase in cyclic AMP levels, which causes vasodilation and improves blood flow to the limbs.\nReduced Pain: It effectively reduces pain and discomfort in the legs associated with intermittent claudication, allowing patients to walk longer distances without pain.\nPlatelet Aggregation Inhibition: Cilostazol inhibits platelet aggregation, reducing the risk of blood clots and enhancing cardiovascular health.\nEnhanced Physical Activity: By alleviating symptoms of intermittent claudication, Cilostazol helps patients increase their physical activity and improve overall fitness.\nBenefits of CILOSTAZONE 100\nEffective Symptom Relief: CILOSTAZONE 100 provides robust relief from intermittent claudication symptoms, significantly reducing pain and discomfort in the legs.\nImproved Circulation: The medication enhances blood flow to the extremities, improving circulation and overall vascular health.\nIncreased Mobility: By reducing pain during walking, CILOSTAZONE 100 enables patients to increase their mobility and engage more actively in daily activities.\nPrevention of Blood Clots: Cilostazol’s platelet aggregation inhibition properties help prevent blood clot formation, reducing the risk of cardiovascular events.\nDosage and Administration\nDosage\nIntermittent Claudication: The typical dosage for adults is one tablet (100 mg) taken twice daily, 30 minutes before or 2 hours after breakfast and dinner. The dosage may be adjusted by the healthcare provider based on the patient’s response and specific health needs.\nAdministration\nOral Use: Swallow the tablet whole with a full glass of water. It should be taken on an empty stomach, either 30 minutes before or 2 hours after meals.\nConsistency: For optimal results, take CILOSTAZONE 100 at the same times each day to maintain consistent medication levels in your bloodstream.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW \nhttps://www.sterisonline.com/product/cilostazone-100-133550",
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