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"description": "MAGRAL 160 is a pharmaceutical medication containing megestrol acetate 160 mg, a synthetic progestin known for its potent antineoplastic and appetite-stimulating properties. This drug is primarily prescribed to manage significant health challenges such as unexplained weight loss, anorexia, and cachexia, especially in patients suffering from chronic conditions like cancer or AIDS. Additionally, megestrol acetate functions as a hormone therapy agent employed in the treatment of certain hormone-sensitive malignancies. Its dual action both supports tumor management and improves patients' nutritional status by stimulating appetite and promoting weight gain, thereby enhancing overall quality of life. The drug is regarded as a crucial option in oncology and palliative care for managing complex conditions related to hormone-dependent cancers and severe wasting syndromes.\n\nWhat is MAGRAL 160?\nMAGRAL 160 is an oral medication formulated with megestrol acetate 160 mg, a synthetic progestin hormone derivative. It works primarily by modulating hormone receptors and altering hormone levels that influence the growth of hormone-responsive tumors such as breast and endometrial cancers. Apart from its antineoplastic action, it stimulates appetite by acting on the hypothalamic centers responsible for hunger, helping patients suffering from severe weight loss regain a healthy appetite and weight.\n\nUses of MAGRAL 160\n\nTo treat hormone-dependent cancers, specifically advanced breast cancer and endometrial cancer.\n\nTo stimulate appetite and promote weight gain in patients experiencing anorexia, cachexia, or unexplained severe weight loss related to chronic illnesses like cancer or AIDS.\n\nTo manage wasting syndromes that lead to malnutrition and significant weight loss.\n\nTo serve as an antineoplastic agent in hormone-sensitive malignancies.\n\nIn short, MAGRAL 160 is primarily used to treat anorexia and cachexia or serious unexplained weight loss and is also used as an antineoplastic agent to treat certain types of malignancy.\n\nSide Effects of MAGRAL 160\n\nWeight gain (often desirable but can be excessive)\n\nFluid retention and edema (swelling)\n\nNausea and vomiting\n\nDiarrhea or constipation\n\nVaginal bleeding or spotting in women\n\nFatigue, weakness, and insomnia\n\nHeadache and dizziness\n\nIncreased risk of blood clots (deep vein thrombosis or pulmonary embolism)\n\nHormonal imbalances, such as decreased sex hormone levels, which can lead to sexual dysfunction or bone density loss\n\nAllergic reactions including rash or itching\n\nPatients should report severe or unusual symptoms, especially signs of blood clots such as limb swelling, chest pain, or sudden shortness of breath, immediately to their healthcare provider.\n\nPrecautions before Using MAGRAL 160\n\nInform your doctor if you are pregnant, breastfeeding, or planning to conceive as MAGRAL 160 is contraindicated in pregnancy.\n\nDisclose any history of blood clots, cardiovascular diseases, liver or kidney impairment.\n\nPatients with diabetes should monitor blood sugar closely as megestrol acetate may cause hyperglycemia.\n\nAvoid sudden discontinuation without medical advice to prevent potential hormonal withdrawal effects.\n\nRegular monitoring is required, including hormone levels and blood tests, to assess efficacy and safety during treatment.\n\nUse cautiously in patients at risk for deep vein thrombosis or pulmonary embolism due to increased clotting risks.\n\nDrug Interactions: What Drugs Interact with MAGRAL 160?\n\nCYP3A4 enzyme inducers (e.g., rifampin, phenytoin) may reduce the effectiveness of megestrol acetate by increasing its metabolism.\n\nConcurrent use with blood thinners (anticoagulants) requires careful monitoring as MAGRAL 160 might influence clotting parameters.\n\nCombining with drugs that affect hormonal pathways, such as other hormonal therapies or corticosteroids, may alter treatment outcomes.\n\nInteractions with diabetes medications might necessitate dose adjustment due to potential effects on blood sugar control.\n\nCareful medical supervision is necessary when used with immunosuppressants or other chemotherapy agents to avoid additive side effects or altered drug levels.\n\nConclusion\nMAGRAL 160, containing megestrol acetate 160 mg, is a clinically validated medication widely used to manage complex conditions such as hormone-dependent cancers as well as severe weight loss due to anorexia and cachexia. Its unique ability to act both as an antineoplastic agent and an appetite stimulant makes it invaluable in improving patient outcomes, nutritional status, and overall quality of life. Patients prescribed MAGRAL 160 should adhere strictly to their healthcare provider’s instructions and report any adverse effects promptly. This medication should always be used under medical supervision to ensure optimal benefits and minimize risks.",
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"description": "ST-GLIPTIN M 100/500 is an oral antidiabetic medication designed to help manage Type 2 Diabetes Mellitus effectively. It combines two powerful ingredients, sitagliptin and metformin hydrochloride, which work together to help control blood sugar levels in adults.\n\nKey Ingredients:\n\nSitagliptin (100 mg): A DPP-4 inhibitor that helps increase the levels of incretin hormones, thereby stimulating insulin release and reducing glucose production by the liver.\n\nMetformin Hydrochloride (500 mg): A biguanide that improves insulin sensitivity and reduces hepatic glucose production.\n\nKey Benefits:\n\nHelps maintain healthy blood glucose levels.\n\nEnhances insulin sensitivity in the body.\n\nLowers glucose production in the liver.\n\nReduces the risks associated with high blood sugar, like cardiovascular complications.\n\nHow Does It Work?\nSitagliptin works by inhibiting the DPP-4 enzyme, which prolongs the activity of incretin hormones. These hormones help regulate blood sugar levels by increasing insulin release from the pancreas and decreasing glucagon levels. Metformin acts primarily by reducing the amount of sugar the liver produces and increasing the body's response to insulin. Together, they help achieve better glycemic control.\n\nDirections for Use:\nTake ST-GLIPTIN M 100/500 as prescribed by your healthcare professional. It is usually taken with meals to reduce gastrointestinal side effects. Do not skip doses and avoid self-adjusting the medication without consulting your doctor.\n\nSide Effects:\nSome common side effects may include:\n\nNausea or vomiting\n\nDiarrhea\n\nStomach upset\n\nHeadache\n\nSerious side effects are rare but may include lactic acidosis, allergic reactions, or severe hypoglycemia. Consult your healthcare provider immediately if you experience unusual symptoms.",
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"description": "TENELIGOLD PIO 20/15 \nTeneligliptin & Pioglitazone\nIntroduction\nTENELIGOLD PIO 20/15 combines two antidiabetic medications, Teneligliptin and Pioglitazone, in a single formulation. This combination is designed to manage type 2 diabetes mellitus by targeting different aspects of glucose metabolism, thereby improving glycemic control in patients who are inadequately controlled with monotherapy or require dual therapy.\n\nComposition\n\nTeneligliptin: A dipeptidyl peptidase-4 (DPP-4) inhibitor that enhances insulin secretion and reduces glucagon release, thereby lowering blood glucose levels.\nPioglitazone: A thiazolidinedione (TZD) that improves insulin sensitivity in peripheral tissues (muscle and adipose tissue) and reduces hepatic glucose production.\nMechanism of Action\n\nTeneligliptin: Inhibits the degradation of incretin hormones (GLP-1 and GIP), which play a key role in glucose-dependent insulin secretion and suppression of glucagon secretion.\nPioglitazone: Activates peroxisome proliferator-activated receptor gamma (PPAR-γ), leading to improved insulin sensitivity, enhanced glucose uptake in peripheral tissues, and reduced hepatic glucose production.\nIndications\nTENELIGOLD PIO 20/15 is indicated for:\n\nType 2 Diabetes Mellitus: Used to improve glycemic control in adults who are inadequately controlled with diet and exercise alone or with other antidiabetic medications.\nDosage and Administration\n\nThe typical dosage is one tablet of TENELIGOLD PIO 20/15 taken orally once daily, preferably with meals.\nDosage adjustments may be necessary based on individual patient response and tolerability.\nIt is important to adhere to the prescribed dosage regimen to achieve optimal glycemic control.\nSide Effects\nCommon side effects may include:\n\nHypoglycemia (especially when used in combination with insulin or sulfonylureas)\nEdema (fluid retention)\nWeight gain\nHeadache\nNasopharyngitis (common cold)\nMore severe side effects can include:\n\nHeart failure (especially in patients with pre-existing cardiovascular disease)\nHepatic dysfunction (monitor liver function tests periodically)\nBone fractures (especially in women)\nPrecautions\n\nHeart Failure: Use with caution in patients with a history of heart failure or other cardiovascular diseases.\nBladder Cancer: Pioglitazone has been associated with an increased risk of bladder cancer; therefore, it should be used cautiously in patients with a history of bladder cancer or with risk factors.\nLiver Function: Monitor liver function tests before starting treatment and periodically thereafter, as Pioglitazone may cause hepatic dysfunction.\nPregnancy and Lactation: Use during pregnancy and lactation should be avoided unless the potential benefits outweigh the risks.\nDrug Interactions\n\nInsulin/Sulfonylureas: Increased risk of hypoglycemia when used concomitantly with insulin or sulfonylureas.\nGemfibrozil: May increase Pioglitazone levels, requiring dose adjustment.\nCYP2C8 Inhibitors (e.g., Gemfibrozil): May increase Pioglitazone concentrations, necessitating monitoring for adverse effects.\nConclusion\nTENELIGOLD PIO 20/15 offers a dual-action approach to managing type 2 diabetes mellitus by combining Teneligliptin and Pioglitazone. This combination helps improve glycemic control through different mechanisms: enhancing insulin secretion and sensitivity. It is crucial to use this medication under the guidance of a healthcare professional to optimize treatment outcomes while minimizing the risk of side effects. Regular monitoring for efficacy and safety parameters, including blood glucose levels and potential adverse effects, is essential for managing diabetes effectively with TENELIGOLD PIO 20/15.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n\n",
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"description": "DIOWELPREX 250 ORAL SOLUTION \nDivalproex (250mg/5ml)\nIntroduction\nDIOWELPREX 250 ORAL SOLUTION contains Divalproex (250mg/5ml), an anticonvulsant and mood-stabilizing medication used to treat various neurological and psychiatric conditions. It is particularly effective in managing epilepsy, bipolar disorder, and preventing migraine headaches.\n\nComposition\n\nDivalproex Sodium (250mg/5ml): A stable coordination compound comprised of sodium valproate and valproic acid in a 1:1 molar relationship, providing a source of valproate ion which exhibits anticonvulsant and mood-stabilizing properties.\nMechanism of Action\nDivalproex works by increasing the levels of gamma-aminobutyric acid (GABA) in the brain, an inhibitory neurotransmitter that helps calm neuronal activity. It stabilizes electrical activity in the brain, reducing the frequency and severity of seizures, stabilizing mood in bipolar disorder, and preventing migraine headaches by altering the way nerves send signals.\n\nIndications\nDIOWELPREX 250 ORAL SOLUTION is indicated for:\n\nEpilepsy: Used to control various types of seizures including complex partial seizures and simple and complex absence seizures.\nBipolar Disorder: Helps in the management of manic episodes associated with bipolar disorder.\nMigraine Prophylaxis: Used to prevent migraine headaches.\nDosage and Administration\n\nEpilepsy: The initial dose is typically 10-15 mg/kg/day, gradually increased as needed and tolerated to achieve optimal clinical response.\nBipolar Disorder: The initial dose is generally 750 mg/day, given in divided doses, adjusted according to clinical response.\nMigraine Prophylaxis: The initial dose is usually 250 mg twice daily, adjusted as necessary.\nIt is essential to follow the prescribed dosage and administration instructions provided by a healthcare professional. The oral solution should be measured accurately using a dosing syringe or cup to ensure the correct dose is administered.\nSide Effects\nCommon side effects may include:\n\nNausea\nDrowsiness\nDizziness\nTremor\nHair loss\nWeight gain\nGastrointestinal disturbances\nMore severe side effects can include:\n\nLiver damage\nPancreatitis\nThrombocytopenia (low platelet count)\nHyperammonemia (high levels of ammonia in the blood)\nPrecautions\n\nLiver Function: Regular monitoring of liver function tests is recommended due to the risk of hepatotoxicity.\nPancreatitis: Patients should be monitored for signs of pancreatitis.\nPregnancy: Divalproex is associated with an increased risk of congenital malformations and should be used during pregnancy only if absolutely necessary and prescribed by a healthcare provider.\nBleeding Disorders: Caution is advised in patients with known bleeding disorders due to the risk of thrombocytopenia.\nDrug Interactions\n\nAntiepileptic Drugs: Concurrent use with other antiepileptic drugs may require dosage adjustments.\nWarfarin: May enhance the anticoagulant effect, necessitating close monitoring of INR levels.\nTopiramate: Co-administration can lead to hyperammonemia and encephalopathy.\nAlcohol: Should be avoided as it can exacerbate the side effects of Divalproex and further impair mental and motor skills.\nConclusion\nDIOWELPREX 250 ORAL SOLUTION is an effective medication for managing epilepsy, bipolar disorder, and preventing migraines. With its active ingredient Divalproex, it helps stabilize neuronal activity and mood. Proper dosage and administration under the guidance of a healthcare professional are essential to maximize benefits and minimize potential side effects. Regular monitoring and adherence to medical advice ensure the safe and effective use of DIOWELPREX 250 ORAL SOLUTION.\nFor further information: \nEMAIL: info@sterispharma.com / contact@sterispharma.com \n CALL/WHATSAPP: 7877551268, 7849827488 \n Order NOW\n",
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