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"name": "Lopinavir 200mg Ritonavir 50mg",
"description": "RITONATERIS LP is a combination formulation containing Lopinavir and Ritonavir, two well-established antiretroviral agents that work together to inhibit viral replication. This fixed-dose combination is designed to enhance the effectiveness of treatment by improving drug levels and prolonging the action of lopinavir in the body.\n\nLopinavir belongs to the class of protease inhibitors, which act by blocking the protease enzyme essential for viral maturation. Ritonavir, although also a protease inhibitor, is primarily used here as a pharmacokinetic enhancer. It slows down the metabolism of lopinavir, allowing higher and more sustained concentrations in the bloodstream. This synergy makes RITONATERIS LP a reliable option in combination therapy regimens.\n\nManufactured with strict quality standards, RITONATERIS LP ensures consistent potency, stability, and performance. The formulation is intended for use as part of a broader therapeutic approach under professional supervision.\n\nUses of RITONATERIS LP\n\nRITONATERIS LP is primarily used in the management of viral infections where protease inhibition is required, particularly in combination regimens. It is not used as a standalone option but rather as part of a comprehensive treatment strategy.\n\nKey Uses Include:\n\nSuppression of viral replication by inhibiting protease enzyme activity\n\nReducing viral load when used in combination with other compatible agents\n\nSupporting long-term viral control strategies\n\nEnhancing treatment effectiveness through boosted drug exposure\n\nThis combination has been widely studied and utilized due to its dependable action and synergistic mechanism.\n\nHow RITONATERIS LP Works\n\nThe effectiveness of RITONATERIS LP lies in its dual-action mechanism:\n\nLopinavir\n\nInhibits the viral protease enzyme\n\nPrevents the virus from producing mature, infectious particles\n\nReduces the ability of the virus to multiply and spread\n\nRitonavir\n\nInhibits liver enzymes responsible for breaking down lopinavir\n\nIncreases the concentration and duration of lopinavir in the blood\n\nEnhances overall treatment efficiency\n\nTogether, these actions lead to sustained viral suppression and improved therapeutic outcomes when used correctly.\n\nKey Benefits of RITONATERIS LP\n1. Enhanced Effectiveness\n\nThe presence of ritonavir boosts lopinavir levels, ensuring consistent activity and reducing the risk of sub-therapeutic exposure.\n\n2. Proven Combination Strategy\n\nThe lopinavir-ritonavir combination has a long history of clinical use, making it a trusted choice in combination-based regimens.\n\n3. Reduced Dosing Complexity\n\nFixed-dose combinations like RITONATERIS LP simplify dosing schedules, which can improve adherence and continuity.\n\n4. Broad Compatibility\n\nRITONATERIS LP can be integrated into various combination protocols as advised by professionals.\n\n5. Stable and Reliable Formulation\n\nManufactured under controlled conditions, the product ensures uniform quality and performance across batches.\n\nDosage and Administration\n\nThe dosage of RITONATERIS LP depends on individual factors such as age, treatment plan, and combination regimen. It should always be taken exactly as prescribed.\n\nGeneral guidance includes:\n\nTablets are usually taken orally\n\nOften recommended with food to improve absorption\n\nConsistent timing helps maintain stable drug levels\n\nDo not alter the dose or discontinue use without professional guidance, as this may affect effectiveness.\n\nPossible Side Effects of RITONATERIS LP\n\nLike all combination formulations, RITONATERIS LP may cause side effects in some individuals. These effects are generally manageable and vary in intensity.\n\nCommon Side Effects\n\nNausea or vomiting\n\nDiarrhea or abdominal discomfort\n\nHeadache\n\nFatigue\n\nMild skin reactions\n\nThese effects often improve as the body adjusts to the formulation.\n\nLess Common Side Effects\n\nChanges in lipid levels\n\nAltered taste sensation\n\nSleep disturbances\n\nSerious Side Effects (Require Immediate Attention)\n\nSevere abdominal pain\n\nSigns of liver dysfunction such as yellowing of skin or eyes\n\nSevere allergic reactions\n\nIrregular heartbeat\n\nPrompt medical attention is necessary if serious reactions occur.\n\nPrecautions and Warnings\n\nInform your professional advisor about all other products you are using to avoid interactions\n\nRegular monitoring may be required to assess response and tolerance\n\nNot recommended without supervision in individuals with pre-existing liver conditions\n\nAdherence to the prescribed schedule is critical for effectiveness\n\nStorage Instructions\n\nStore at room temperature\n\nKeep away from moisture and direct sunlight\n\nKeep out of reach of children\nConclusion\nRITONATERIS LP, containing Lopinavir and Ritonavir, is a well-established combination designed to deliver reliable and sustained viral suppression as part of a broader therapeutic strategy. By combining a potent protease inhibitor with a pharmacokinetic enhancer, this formulation maximizes effectiveness while maintaining manageable dosing.",
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"name": "Sodium Chloride Inhalation Solution USP 3% w/v",
"description": "SODICHLOR 3% is a sterile, preservative-free hypertonic saline inhalation solution specifically formulated to help manage respiratory conditions characterized by thick, tenacious mucus secretions. This pharmaceutical-grade formulation contains 3% sodium chloride in purified water, offering a concentration three times higher than normal saline, designed to work through osmotic principles to improve airway clearance and respiratory function.\nAs a trusted therapeutic agent in respiratory care, SODICHLOR 3% represents a non-antibiotic approach to managing chronic respiratory conditions, making it an invaluable tool for patients suffering from cystic fibrosis, chronic obstructive pulmonary disease (COPD), bronchiectasis, and other conditions where mucus clearance is compromised. The solution is administered via nebulization, allowing the medication to reach deep into the bronchial passages where it can exert its therapeutic effects most effectively.\nHow SODICHLOR 3% Works\nThe mechanism of action behind SODICHLOR 3% is elegantly simple yet highly effective. When nebulized and inhaled, the hypertonic saline solution creates an osmotic gradient in the airways. This means that the higher salt concentration in the solution draws water from the surrounding tissues into the airway surface liquid layer. This influx of water hydrates the mucus, making it less viscous and sticky, which significantly improves the ability to cough up and clear secretions from the lungs.\nAdditionally, SODICHLOR 3% helps restore the normal salt and water balance on airway surfaces, which is particularly important in conditions like cystic fibrosis where this balance is naturally disrupted. The solution also stimulates ciliary beat frequency, enhancing the natural cleaning mechanism of the respiratory tract. By improving mucociliary clearance, SODICHLOR 3% helps reduce the bacterial burden in the airways, potentially decreasing the frequency of respiratory infections and exacerbations.\nPrimary Uses and Applications\nSODICHLOR 3% is prescribed for various respiratory conditions where enhanced mucus clearance is clinically beneficial:\nCystic Fibrosis Management: Perhaps the most well-established use, SODICHLOR 3% has become a cornerstone therapy for patients with cystic fibrosis. Regular use helps thin the abnormally thick mucus characteristic of this genetic condition, improving lung function and quality of life while reducing the risk of pulmonary exacerbations.\nChronic Obstructive Pulmonary Disease: For COPD patients who struggle with excessive mucus production and poor clearance, SODICHLOR 3% provides relief by facilitating easier expectoration and improving breathing comfort.\nBronchiectasis: This condition, characterized by permanently damaged and widened airways that trap mucus, benefits significantly from hypertonic saline therapy. SODICHLOR 3% helps clear the pooled secretions that contribute to recurrent infections.\nPost-Operative Respiratory Care: Following certain surgical procedures, particularly thoracic surgeries, SODICHLOR 3% may be used to prevent mucus plugging and atelectasis by maintaining adequate airway hydration.\nSputum Induction: In diagnostic settings, SODICHLOR 3% can be used to induce sputum production for laboratory testing when patients cannot spontaneously produce adequate samples.\nKey Benefits of SODICHLOR 3%\nThe therapeutic advantages of SODICHLOR 3% extend across multiple dimensions of respiratory health:\nEnhanced Mucus Clearance: The primary benefit is the dramatic improvement in the ability to clear thick, sticky mucus from the airways. Patients often report easier breathing and more productive coughing within minutes of treatment.\nImproved Lung Function: Clinical studies have demonstrated that regular use of hypertonic saline solutions like SODICHLOR 3% can lead to measurable improvements in pulmonary function tests, including forced expiratory volume (FEV1) and forced vital capacity (FVC).\nReduced Infection Frequency: By promoting better mucus clearance and reducing bacterial colonization in the airways, SODICHLOR 3% may help decrease the frequency of respiratory infections and disease exacerbations, leading to fewer hospitalizations.\nNon-Antibiotic Therapy: In an era of increasing antibiotic resistance, SODICHLOR 3% offers a mechanical rather than chemical approach to managing respiratory symptoms, making it a valuable addition to any treatment regimen without contributing to resistance patterns.\nCost-Effective Treatment: Compared to many specialized respiratory medications, SODICHLOR 3% represents a relatively affordable therapeutic option that can be used long-term without prohibitive expense.\nQuality of Life Enhancement: Patients using SODICHLOR 3% regularly often report significant improvements in their daily activities, exercise tolerance, and overall sense of well-being due to easier breathing and reduced respiratory distress.\nCompatibility with Other Treatments: SODICHLOR 3% can be safely used alongside other respiratory medications, including bronchodilators, corticosteroids, and antibiotics, as part of a comprehensive treatment plan.\nPotential Side Effects and Considerations\nWhile SODICHLOR 3% is generally well-tolerated, patients should be aware of potential side effects:\nCommon Side Effects: The most frequently reported adverse effects include throat irritation, coughing (especially initially), unpleasant taste, and mild wheezing or chest tightness. These effects are typically transient and often diminish with continued use as the body adapts to the therapy.\nBronchospasm: Some patients, particularly those with hyperreactive airways or asthma, may experience bronchospasm (sudden narrowing of the airways) during or after treatment. This is why healthcare providers often recommend using a bronchodilator before SODICHLOR 3% administration.\nTemporary Oxygen Desaturation: In some cases, especially in patients with severe lung disease, temporary decreases in blood oxygen levels may occur immediately after treatment, though levels typically return to baseline within 30 minutes.\nNasal Congestion and Rhinorrhea: Some patients may experience nasal stuffiness or runny nose following inhalation therapy.\nLess Common Effects: Headache, nausea, dizziness, or voice changes may occasionally occur but are generally mild and self-limiting.\nPatients with certain conditions such as uncontrolled hypertension, severe electrolyte imbalances, or recent hemoptysis should use SODICHLOR 3% only under close medical supervision. As with any medical treatment, it's essential to discuss your complete medical history with your healthcare provider before beginning therapy.\nConclusion\nSODICHLOR 3% represents a scientifically sound, clinically proven approach to managing respiratory conditions complicated by thick mucus secretions. Its mechanism of action—leveraging osmotic principles to hydrate and mobilize airway secretions—addresses a fundamental problem faced by millions of patients with chronic respiratory diseases. The substantial body of evidence supporting its efficacy, combined with its favorable safety profile and cost-effectiveness, makes SODICHLOR 3% an indispensable component of modern respiratory care.",
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"name": "Vitamin E 600 mg Capsule",
"description": "STERI'S VITAMIN E 600 contains Tocopheryl Acetate IP 600 mg, a stable and highly effective form of Vitamin E widely used as a nutritional supplement and antioxidant therapy. Vitamin E is a fat-soluble vitamin that plays a crucial role in protecting cells from oxidative damage, supporting immune function, improving skin and hair health, and maintaining overall well-being.\n\nTocopheryl Acetate is preferred in pharmaceutical formulations because of its excellent stability and better shelf life compared to other forms of Vitamin E. Once ingested, it is converted into active Vitamin E in the body and helps neutralize free radicals that can damage cells, tissues, and organs.\n\nSTERI'S VITAMIN E 600 is commonly recommended for individuals with Vitamin E deficiency, increased oxidative stress, fertility-related concerns, skin disorders, and conditions where antioxidant support is essential. It is suitable for long-term use under medical supervision and is trusted for its quality, purity, and therapeutic effectiveness.\n\nUses of Tocopheryl Acetate IP 600 mg\n\nSTERI'S VITAMIN E 600 is prescribed for a wide range of health conditions due to its antioxidant and protective properties. Key uses include:\n\nTreatment and prevention of Vitamin E deficiency\n\nSupport in male and female infertility\n\nManagement of oxidative stress-related conditions\n\nImprovement of skin texture and elasticity\n\nSupport for hair health and scalp nourishment\n\nAdjunct therapy in cardiovascular health\n\nSupport in neurological and muscular disorders\n\nEnhancing immune system response\n\nSupport during pregnancy (as advised by a doctor)\n\nVitamin E plays an important role in protecting red blood cells, supporting nerve function, and maintaining healthy vision. It is often used as a supportive supplement in patients undergoing long-term medical treatment or those with increased nutritional requirements.\n\nHow Tocopheryl Acetate Works\n\nTocopheryl Acetate functions primarily as a powerful antioxidant. It protects body cells from damage caused by free radicals—unstable molecules generated due to pollution, stress, unhealthy diet, smoking, aging, and certain medical conditions.\n\nOnce absorbed, Tocopheryl Acetate is converted into active Vitamin E, which:\n\nStabilizes cell membranes\n\nPrevents lipid peroxidation\n\nProtects skin cells from UV damage\n\nSupports healthy blood circulation\n\nEnhances reproductive health\n\nBy reducing oxidative stress, Vitamin E helps slow down cellular aging and supports overall metabolic balance.\n\nKey Benefits of STERI'S VITAMIN E 600\n1. Powerful Antioxidant Protection\n\nSTERI'S VITAMIN E 600 helps protect cells from oxidative damage, reducing the risk of chronic diseases and supporting long-term health.\n\n2. Supports Skin Health\n\nVitamin E is well-known for improving skin hydration, reducing dryness, supporting wound healing, and maintaining youthful skin. It is often used in the management of skin disorders and cosmetic health.\n\n3. Improves Hair Strength and Scalp Health\n\nRegular supplementation may help reduce hair fall, strengthen hair roots, and improve scalp circulation, promoting healthier hair growth.\n\n4. Enhances Reproductive Health\n\nTocopheryl Acetate is commonly prescribed in infertility treatments for both men and women. It supports sperm quality, egg health, and hormonal balance.\n\n5. Boosts Immune Function\n\nVitamin E supports immune cells, helping the body fight infections and maintain a strong defense system.\n\n6. Cardiovascular Support\n\nBy reducing oxidative damage to blood vessels, Vitamin E may support heart health and healthy blood circulation.\n\n7. Neurological and Muscle Support\n\nVitamin E is essential for nerve protection and muscle function, especially in individuals with neurological or muscular disorders.\n\nDosage and Administration\n\nThe dosage of STERI'S VITAMIN E 600 should be taken as prescribed by a healthcare professional. Typically:\n\nOne capsule daily after meals\n\nSwallowed whole with water\n\nNot to be crushed or chewed\n\nDosage may vary depending on age, medical condition, and nutritional requirements.\n\nSide Effects of Tocopheryl Acetate IP 600 mg\n\nSTERI'S VITAMIN E 600 is generally well tolerated when taken at recommended doses. However, some individuals may experience mild side effects, including:\n\nCommon Side Effects\n\nNausea\n\nStomach discomfort\n\nHeadache\n\nFatigue\n\nMild diarrhea\n\nRare or Serious Side Effects (High Doses or Prolonged Use)\n\nIncreased risk of bleeding\n\nBlurred vision\n\nSevere weakness\n\nAllergic reactions (rare)\n\nIf any unusual symptoms occur, medical advice should be sought immediately.\n\nPrecautions and Warnings\n\nUse under medical supervision, especially during pregnancy or breastfeeding\n\nPatients with bleeding disorders should consult a doctor before use\n\nAvoid exceeding the recommended dose\n\nInform your doctor about other medications being taken, especially blood thinners\n\nStore in a cool, dry place away from sunlight\n\nConclusion\n\nSTERI'S VITAMIN E 600, containing Tocopheryl Acetate IP 600 mg, is a high-quality Vitamin E supplement designed to provide effective antioxidant protection and comprehensive health support. From enhancing skin and hair health to supporting fertility, immunity, and cardiovascular function, it plays a vital role in maintaining overall wellness.",
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"name": "Magnesium glycine complex and vitamin d3 Tablet",
"description": "FABRICAL D3 represents a breakthrough in nutritional supplementation, combining the superior bioavailability of magnesium glycinate complex with the essential benefits of vitamin D3 (cholecalciferol). This scientifically formulated supplement addresses two of the most common nutritional deficiencies affecting modern populations, offering a comprehensive solution for individuals seeking to optimize their mineral and vitamin intake for overall health and wellness.\nThe unique formulation of FABRICAL D3 harnesses the synergistic relationship between magnesium and vitamin D3, two nutrients that work in tandem to support numerous physiological processes. While magnesium glycinate provides highly absorbable magnesium bound to the amino acid glycine, vitamin D3 delivers the most bioactive form of vitamin D, ensuring maximum therapeutic benefit with minimal gastrointestinal discomfort.\nUnderstanding the Components\nMagnesium Glycinate Complex\nMagnesium glycinate is widely regarded as one of the most bioavailable forms of magnesium supplementation. Unlike other magnesium compounds that may cause digestive upset, the glycinate form is chelated with glycine, an amino acid that facilitates gentle absorption and enhances tolerability. This molecular structure allows magnesium to pass through the intestinal wall more efficiently, delivering therapeutic levels of this essential mineral to tissues throughout the body.\nMagnesium participates in over 300 enzymatic reactions within the human body, making it indispensable for energy production, protein synthesis, muscle function, and nervous system regulation. The glycinate form specifically offers additional calming benefits through glycine's natural ability to support neurotransmitter balance and promote relaxation.\nVitamin D3 (Cholecalciferol)\nVitamin D3 is the biologically active form of vitamin D that the body naturally produces when skin is exposed to sunlight. FABRICAL D3 provides supplemental cholecalciferol to compensate for inadequate sun exposure, dietary insufficiency, or increased physiological demands. Vitamin D3 functions more as a hormone than a traditional vitamin, influencing gene expression and regulating calcium absorption, immune function, and cellular health throughout the body.\nPrimary Uses and Applications\nFABRICAL D3 is designed for individuals experiencing or at risk of magnesium and vitamin D deficiency. Common scenarios warranting supplementation include:\nBone Health Support: The combination supports optimal bone density by facilitating calcium absorption and utilization. Magnesium activates vitamin D, while vitamin D enhances calcium absorption—creating a powerful triad for skeletal integrity.\nMuscle Function and Recovery: Athletes, active individuals, and those experiencing muscle cramps or tension benefit from magnesium's role in muscle contraction and relaxation, while vitamin D supports muscle strength and recovery.\nMood and Cognitive Support: Both nutrients influence neurotransmitter production and brain function. Magnesium glycinate's calming properties combined with vitamin D's mood-regulating effects make FABRICAL D3 valuable for emotional wellness.\nSleep Quality Enhancement: The glycinate component promotes relaxation and may improve sleep quality, while adequate vitamin D levels correlate with better sleep patterns.\nImmune System Fortification: Vitamin D3 plays a critical role in immune cell function, while magnesium supports the immune response through various enzymatic pathways.\nCardiovascular Health: Magnesium supports healthy blood pressure and vascular function, while vitamin D contributes to cardiovascular system regulation.\nEnergy Production: Magnesium is essential for ATP synthesis, the body's primary energy currency, helping combat fatigue and support metabolic efficiency.\nKey Benefits of FABRICAL D3\nEnhanced Bioavailability\nThe magnesium glycinate complex offers superior absorption compared to conventional magnesium oxide or citrate forms, ensuring therapeutic levels reach target tissues without gastrointestinal distress.\nDual-Action Formula\nBy addressing two prevalent nutritional deficiencies simultaneously, FABRICAL D3 provides comprehensive nutritional support in a single convenient tablet.\nGentle on Digestion\nThe glycinate form minimizes the laxative effect commonly associated with magnesium supplementation, making it suitable for individuals with sensitive digestive systems.\nSynergistic Nutrient Interaction\nMagnesium activates vitamin D, while vitamin D enhances magnesium absorption—creating a mutually beneficial relationship that maximizes the efficacy of both nutrients.\nNervous System Support\nThe combination promotes neurological health, supporting stress response, cognitive function, and overall mental clarity.\nBone Density Optimization\nTogether, these nutrients create an optimal environment for calcium utilization, supporting skeletal strength and reducing fracture risk.\nImproved Muscle Function\nThe formula addresses muscle cramping, tension, and weakness while supporting post-exercise recovery and physical performance.\nConvenient Dosing\nSingle-tablet formulation simplifies supplementation routines, improving compliance and consistency.\nPotential Side Effects and Considerations\nWhile FABRICAL D3 is generally well-tolerated, some individuals may experience side effects, particularly when beginning supplementation or taking doses exceeding recommended guidelines:\nMagnesium-Related Effects:\n\nMild digestive upset, though significantly less common with glycinate forms\nDiarrhea if dosage exceeds individual tolerance (typically above 400-500mg elemental magnesium)\nNausea in sensitive individuals\n\nVitamin D3-Related Effects:\n\nHypercalcemia (elevated blood calcium) with excessive long-term supplementation\nNausea or vomiting with very high doses\nKidney stone formation in susceptible individuals taking excessive amounts\nFatigue or weakness if overdosed\n\nGeneral Considerations:\nIndividuals with kidney disease should consult healthcare providers before use, as magnesium excretion may be impaired. Those taking medications including antibiotics, bisphosphonates, diuretics, or heart medications should discuss potential interactions with their physician. Vitamin D supplementation should be monitored in individuals with hyperparathyroidism, sarcoidosis, or other conditions affecting calcium metabolism.\nRecommended Usage\nFor optimal results, take FABRICAL D3 as directed by healthcare professionals or according to package instructions. Generally, supplementation is most effective when taken with food containing healthy fats, which enhance vitamin D3 absorption. Consistency is crucial—daily supplementation allows the body to maintain steady nutrient levels and experience cumulative benefits over time.\nIndividuals should consider periodic blood testing to monitor vitamin D and magnesium status, ensuring supplementation achieves therapeutic ranges without exceeding safe upper limits. Healthcare providers can adjust dosing based on individual biochemistry, lifestyle factors, and health objectives.\nConclusion\nFABRICAL D3 represents an intelligently designed nutritional supplement that addresses two fundamental nutritional gaps affecting millions worldwide. By combining highly bioavailable magnesium glycinate with vitamin D3, this formulation delivers comprehensive support for bone health, muscle function, immune system performance, mood regulation, and overall vitality.\nThe scientific synergy between these nutrients—where each enhances the other's absorption and function—makes FABRICAL D3 more than a simple combination product. It's a thoughtfully engineered solution that recognizes how nutrients work together within the complex systems of human physiology.",
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"name": "FABRICAL MG K₂7",
"description": "FABRICAL MG K₂7 represents a scientifically advanced nutritional supplement that combines essential minerals and vitamins in a synergistic formulation designed to support optimal bone health, cardiovascular function, and overall metabolic wellness. This innovative product brings together six critical nutrients—Calcium Citrate Maleate, Magnesium Bisglycinate, Vitamin D3, Vitamin K2-7 (Menaquinone-7), Zinc, and Methylcobalamin—in precise therapeutic ratios that maximize bioavailability and clinical effectiveness.\nUnlike conventional calcium supplements that focus solely on calcium supplementation, FABRICAL MG K₂7 adopts a comprehensive, multi-nutrient approach that addresses the complex interplay between various micronutrients essential for skeletal integrity, neuromuscular function, immune competence, and metabolic regulation. This sophisticated formulation reflects current understanding of nutritional biochemistry, recognizing that optimal health outcomes require balanced supplementation rather than isolated nutrient provision.\nThe product has been meticulously formulated to address the growing epidemic of nutritional deficiencies affecting diverse populations, from elderly individuals experiencing age-related bone loss to young adults with suboptimal dietary intake, pregnant women with increased nutritional demands, and individuals with chronic conditions affecting nutrient absorption or utilization. FABRICAL MG K₂7 serves as a convenient, evidence-based solution for maintaining nutritional adequacy and supporting long-term health across various life stages.\nDetailed Understanding of FABRICAL MG K₂7 Components\nCalcium Citrate Maleate: Superior Calcium Bioavailability\nCalcium Citrate Maleate represents the premium form of calcium supplementation, offering significantly enhanced absorption compared to traditional calcium carbonate. This advanced calcium complex demonstrates approximately 25-30% better bioavailability, making it particularly valuable for individuals with reduced gastric acid production, including elderly populations and those taking proton pump inhibitors or H2-receptor antagonists. Unlike calcium carbonate, which requires acidic conditions for optimal dissolution, Calcium Citrate Maleate can be absorbed efficiently regardless of meal timing or stomach pH, providing greater flexibility and convenience.\nThe maleate component further enhances calcium absorption and utilization by supporting cellular energy metabolism and mitochondrial function. This sophisticated formulation ensures that supplemented calcium reaches target tissues—bones, teeth, muscles, and nerves—where it performs essential physiological functions rather than accumulating in soft tissues where it could potentially contribute to unwanted calcification.\nMagnesium Bisglycinate: The Gentle Magnesium Choice\nMagnesium Bisglycinate, also known as magnesium glycinate, stands as one of the most bioavailable and well-tolerated forms of magnesium supplementation. This chelated form, where magnesium is bound to two molecules of the amino acid glycine, offers exceptional absorption rates approaching 80-90% while minimizing the gastrointestinal side effects—particularly diarrhea—commonly associated with other magnesium forms like magnesium oxide or sulfate.\nMagnesium plays over 300 enzymatic roles throughout the body, making it indispensable for energy production, protein synthesis, muscle and nerve function, blood glucose control, and blood pressure regulation. Within FABRICAL MG K₂7, magnesium works synergistically with calcium, maintaining the critical calcium-magnesium balance essential for proper muscular contraction and relaxation, cardiovascular rhythm stability, and skeletal mineralization.\nVitamin D3: The Sunshine Vitamin in Its Active Form\nVitamin D3 (cholecalciferol) represents the most bioactive form of vitamin D, identical to what human skin synthesizes upon ultraviolet B exposure. This fat-soluble vitamin functions more accurately as a hormone, regulating calcium absorption from the intestines, maintaining serum calcium and phosphorus concentrations within optimal ranges, and modulating bone remodeling by both osteoblasts and osteoclasts.\nBeyond skeletal functions, Vitamin D3 exerts profound influences on immune system regulation, cellular differentiation and proliferation, neuromuscular function, and inflammation modulation. Vitamin D receptors exist throughout the body—in tissues ranging from the brain and heart to immune cells and muscle—highlighting its systemic importance. The inclusion of Vitamin D3 in FABRICAL MG K₂7 ensures that supplemented calcium can be effectively absorbed and utilized, preventing the futility of calcium supplementation in vitamin D-deficient states.\nVitamin K2-7: The Missing Link in Bone and Cardiovascular Health\nVitamin K2-7, specifically the menaquinone-7 (MK-7) form, represents perhaps the most revolutionary component of FABRICAL MG K₂7. This long-chain vitamin K2 demonstrates superior bioavailability and longer half-life compared to vitamin K1 (phylloquinone) found in green vegetables or shorter-chain K2 forms. Vitamin K2-7's critical function involves activating proteins responsible for proper calcium utilization—specifically matrix Gla protein (MGP) and osteocalcin.\nOsteocalcin, produced by bone-building osteoblasts, requires vitamin K2-dependent carboxylation to become active and effectively bind calcium into bone matrix, strengthening skeletal structure. Simultaneously, Vitamin K2-7 activates MGP, which prevents calcium deposition in arterial walls and soft tissues, directing calcium away from cardiovascular structures where it contributes to atherosclerosis and arterial stiffness. This dual action—promoting bone calcification while preventing vascular calcification—makes Vitamin K2-7 uniquely valuable, addressing the “calcium paradox” where individuals may simultaneously experience osteoporosis and arterial calcification.\nZinc: The Multifunctional Essential Mineral\nZinc, incorporated into FABRICAL MG K₂7 in highly bioavailable form, serves numerous critical physiological functions spanning immune competence, wound healing, protein synthesis, DNA synthesis, and cellular division. Regarding bone health specifically, zinc influences bone metabolism by supporting osteoblast activity and collagen synthesis, contributing to bone matrix formation and mineralization. Zinc also functions as a cofactor for alkaline phosphatase, an enzyme essential for bone mineralization.\nBeyond skeletal contributions, zinc supports immune system function, acting as a critical component of innumerable enzymes involved in immune cell development and function. Zinc deficiency impairs both innate and adaptive immunity, increasing susceptibility to infections. The mineral also supports sensory function (taste and smell), cognitive function, reproductive health, and skin integrity.\nMethylcobalamin: The Bioactive Vitamin B12\nMethylcobalamin represents the active, coenzyme form of vitamin B12, requiring no metabolic conversion to exert biological activity. This form demonstrates superior neurological benefits compared to cyanocobalamin, the synthetic form commonly used in supplements. Methylcobalamin directly participates in methionine synthesis and methylation reactions critical for nervous system health, DNA synthesis, red blood cell formation, and homocysteine metabolism.\nElevated homocysteine, resulting from inadequate B12 status, associates with increased cardiovascular disease risk, cognitive decline, and bone fragility. By supporting homocysteine conversion to methionine, methylcobalamin in FABRICAL MG K₂7 contributes to cardiovascular protection and potentially supports bone health through mechanisms independent of its well-established neurological and hematological roles.\nPrimary Uses and Clinical Applications of FABRICAL MG K₂7\nComprehensive Bone Health Support\nThe primary indication for FABRICAL MG K₂7 centers on comprehensive bone health support across various life stages and clinical scenarios. The formulation addresses all critical aspects of skeletal health: providing adequate calcium substrate for mineralization, ensuring calcium absorption through Vitamin D3, directing calcium into bone matrix via Vitamin K2-7, supporting bone matrix formation through magnesium and zinc, and protecting against homocysteine-related bone fragility through methylcobalamin.\nThis makes FABRICAL MG K₂7 particularly valuable for:\nOsteoporosis Prevention and Management: Postmenopausal women and elderly men experiencing age-related bone loss benefit from the formulation's comprehensive approach, potentially slowing bone density decline and reducing fracture risk.\nGrowing Children and Adolescents: During peak bone-building years, FABRICAL MG K₂7 supports optimal skeletal development, helping children and teenagers achieve maximum peak bone mass—a critical determinant of lifelong skeletal health.\nPregnancy and Lactation: Women during pregnancy and breastfeeding experience dramatically increased calcium demands. FABRICAL MG K₂7 helps prevent maternal bone density loss while supporting fetal skeletal development.\nCardiovascular Protection Through Proper Calcium Distribution\nThe Vitamin K2-7 component positions FABRICAL MG K₂7 as more than a bone health supplement—it's a cardiovascular protective formulation. By activating matrix Gla protein, the supplement helps prevent arterial calcification, potentially reducing cardiovascular disease risk. This dual benefit addresses the concerning observation that some individuals taking calcium supplements without adequate Vitamin K2 may experience increased cardiovascular events due to inappropriate calcium deposition in arterial walls.\nNeurological and Cognitive Support\nThe methylcobalamin component provides neurological support, particularly valuable for elderly individuals at risk for vitamin B12 deficiency due to reduced intrinsic factor production or those taking medications that impair B12 absorption (such as metformin or proton pump inhibitors). Adequate B12 status supports cognitive function, mood regulation, nerve conduction, and may help prevent peripheral neuropathy.\nImmune System Enhancement\nBoth zinc and vitamin D3 within FABRICAL MG K₂7 contribute significantly to immune competence. Vitamin D modulates both innate and adaptive immunity, while zinc supports immune cell development and function. This immune support proves particularly relevant during seasonal illness peaks or for individuals with compromised immunity.\nMuscle Function and Exercise Performance\nMagnesium's role in muscle contraction and relaxation, combined with calcium's involvement in excitation-contraction coupling, makes FABRICAL MG K₂7 valuable for athletes and physically active individuals. The formulation may help prevent exercise-associated muscle cramps, support recovery, and maintain electrolyte balance.\nKey Benefits of FABRICAL MG K₂7\nEnhanced Bioavailability and Absorption\nUnlike basic supplements using inferior ingredient forms, FABRICAL MG K₂7 utilizes premium, highly bioavailable compounds:\n\nCalcium Citrate Maleate offers superior absorption compared to calcium carbonate\nMagnesium Bisglycinate provides excellent absorption without gastrointestinal distress\nVitamin D3 is more potent than D2\nVitamin K2-7 (MK-7) has longer half-life and better tissue distribution than K1 or shorter-chain K2 forms\nMethylcobalamin is the active B12 form requiring no conversion\n\nThis superior bioavailability means lower doses can achieve therapeutic effects, reducing pill burden and potential adverse effects while maximizing benefits.\nSynergistic Nutrient Interactions\nFABRICAL MG K₂7's formulation recognizes that nutrients work together, not in isolation:\n\nVitamin D3 enhances calcium absorption while Vitamin K2-7 directs where that calcium goes\nMagnesium supports Vitamin D activation and calcium metabolism\nZinc supports bone matrix formation complementing calcium's role in mineralization\nMethylcobalamin supports methylation pathways that may influence bone health\n\nThis synergy delivers benefits exceeding what individual nutrients could provide separately.\nComprehensive Rather Than Fragmented Nutritional Support\nRather than requiring multiple separate supplements, FABRICAL MG K₂7 provides comprehensive support in a single, convenient formulation. This simplification improves compliance, reduces costs compared to purchasing individual supplements, and eliminates concerns about nutrient imbalances from uncoordinated supplementation.\nProtection Against the Calcium Paradox\nPerhaps the most significant benefit stems from the Vitamin K2-7 inclusion, which addresses the calcium paradox—simultaneously strengthening bones while protecting cardiovascular health by preventing arterial calcification. This represents a critical advancement over traditional calcium supplements that may inadvertently increase cardiovascular risk when taken without adequate Vitamin K2.\nSupport Across Multiple Physiological Systems\nBeyond bones, FABRICAL MG K₂7 benefits:\n\nCardiovascular System: Through arterial protection and homocysteine management\nNervous System: Via methylcobalamin's neurological support\nImmune System: Through vitamin D3 and zinc's immunomodulatory effects\nMuscular System: Via magnesium and calcium's roles in contraction\nMetabolic System: Through magnesium's involvement in glucose metabolism\n\nThis multi-system support delivers value far exceeding simple bone health supplementation.\nPotential Side Effects and Safety Considerations\nGenerally Well-Tolerated with Minimal Side Effects\nFABRICAL MG K₂7, when taken as directed, demonstrates excellent tolerability in most individuals. The selection of highly bioavailable, gentle nutrient forms specifically minimizes adverse effects common with inferior formulations.\nMild Gastrointestinal Effects\nSome users may initially experience mild digestive symptoms including:\n\nSlight nausea, particularly if taken on an empty stomach\nMinor bloating or gas\nMild constipation (though less likely than with calcium carbonate formulations)\n\nThese effects typically resolve within a few days as the body adjusts and can be minimized by taking the supplement with meals and ensuring adequate hydration.\nRare Allergic Reactions\nAlthough uncommon, some individuals may experience hypersensitivity to ingredients or excipients in the formulation. Signs include rash, itching, or swelling. Discontinuation and medical consultation are warranted if such reactions occur.\nConsiderations for Specific Populations\nIndividuals on Anticoagulants: Vitamin K2, while generally safer regarding coagulation than K1, may theoretically interact with warfarin. Patients on anticoagulation therapy should consult healthcare providers before starting FABRICAL MG K₂7, though recent evidence suggests K2 supplementation at consistent doses may not significantly affect INR stability.\nKidney Disease Patients: Individuals with chronic kidney disease should consult nephrologists before supplementing with calcium, magnesium, or vitamin D due to altered mineral metabolism and increased calcification risks in renal impairment.\nHypercalcemia Risk: Those with conditions predisposing to elevated calcium (hyperparathyroidism, sarcoidosis, certain cancers) should avoid supplementation without medical supervision.\nImportance of Appropriate Dosing\nExceeding recommended doses may increase adverse effect risks including:\n\nHypercalcemia (excessive calcium) causing nausea, constipation, kidney stones\nHypermagnesemia (excessive magnesium) causing diarrhea, cardiac abnormalities\nVitamin D toxicity (though requiring very high doses sustained over time)\n\nFollowing manufacturer's recommendations and consulting healthcare providers regarding individual needs ensures safe, effective use.\nRecommended Usage and Dosage Guidelines\nFABRICAL MG K₂7 should be taken according to manufacturer recommendations, typically one to two tablets daily with meals for optimal absorption of fat-soluble vitamins (D3 and K2-7). Taking the supplement with food containing some dietary fat further enhances absorption of these critical nutrients while minimizing potential gastrointestinal discomfort.\nConsistency in timing supports optimal benefits, as regular daily supplementation maintains stable nutrient levels. For individuals on multiple medications, spacing FABRICAL MG K₂7 administration at least two hours from certain medications (particularly thyroid hormones, bisphosphonates, or antibiotics) prevents potential absorption interference.\nIndividual requirements vary based on age, sex, dietary intake, health status, and specific deficiency risks. Healthcare provider consultation helps determine whether standard dosing suffices or whether adjustments are warranted. Periodic monitoring of vitamin D levels and other relevant biomarkers may be recommended to ensure supplementation achieves therapeutic goals without overshooting into excess.\nConclusion: FABRICAL MG K₂7 as a Comprehensive Nutritional Solution\nFABRICAL MG K₂7 stands as a sophisticated, scientifically formulated nutritional supplement that transcends traditional approaches to bone health support. By combining six synergistic nutrients in highly bioavailable forms, this innovative product addresses the complex, interconnected nature of skeletal health, cardiovascular protection, neurological function, and overall metabolic wellness.\nThe formulation's greatest strength lies in its comprehensive approach—recognizing that optimal health outcomes require balanced nutrition rather than isolated nutrient provision. The inclusion of Vitamin K2-7 particularly distinguishes FABRICAL MG K₂7 from conventional calcium supplements, addressing the critical calcium paradox and ensuring supplemented calcium strengthens bones while protecting cardiovascular structures.\nFor individuals seeking to support bone density, prevent osteoporosis, ensure adequate nutritional status during life stages of increased demand, or simply maintain optimal health through evidence-based supplementation, FABRICAL MG K₂7 offers a convenient, effective solution backed by nutritional science. Its excellent tolerability, superior ingredient quality, and multi-system benefits make it suitable for diverse populations from growing adolescents to active adults and elderly individuals concerned about age-related health challenges.\nAs with any nutritional supplement, FABRICAL MG K₂7 works best as part of a comprehensive health strategy including balanced nutrition, regular physical activity, adequate sleep, stress management, and appropriate medical care. It complements rather than replaces healthy lifestyle practices, providing nutritional insurance that helps fill gaps in modern diets while supporting long-term wellness.\nWhether you're proactively supporting your skeletal health, addressing identified nutritional deficiencies, or seeking comprehensive multi-nutrient support, FABRICAL MG K₂7 represents a premium choice that combines scientific sophistication with practical convenience, delivering measurable benefits that support vibrant health across all life stages.\n\nDisclaimer: This information is for educational purposes and does not constitute medical advice. Individual nutritional needs vary significantly based on numerous factors. Consult qualified healthcare professionals before starting any supplement regimen, particularly if you have existing health conditions, take medications, are pregnant or nursing, or have specific health concerns. Keep supplements out of reach of children and store according to manufacturer recommendations to maintain product integrity and safety.",
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"description": "ESMOSTRUM IT: Comprehensive Product Guide\nProduct Overview\nESMOSTRUM IT is an advanced pharmaceutical formulation that combines two potent active ingredients—Esomeprazole and Itopride—to provide comprehensive relief from gastrointestinal disorders. This dual-action medication represents a significant advancement in the management of acid-related digestive conditions and motility disorders. By combining a proton pump inhibitor with a prokinetic agent, ESMOSTRUM IT addresses both the underlying causes and symptomatic manifestations of various digestive ailments, offering patients a complete therapeutic solution in a single, convenient dosage form.\nThe synergistic combination of Esomeprazole and Itopride makes ESMOSTRUM IT particularly effective for individuals suffering from gastroesophageal reflux disease (GERD), functional dyspepsia, and other conditions where both excessive acid production and impaired gastric motility contribute to discomfort and disease progression.\nActive Pharmaceutical Ingredients\nEsomeprazole\nEsomeprazole is the S-isomer of omeprazole and belongs to the class of medications known as proton pump inhibitors (PPIs). It works by specifically and irreversibly blocking the hydrogen-potassium adenosine triphosphatase enzyme system (the proton pump) located in the gastric parietal cells. This mechanism effectively reduces gastric acid secretion, providing sustained relief from acid-related symptoms and allowing damaged esophageal and gastric tissue to heal.\nItopride\nItopride is a prokinetic agent that enhances gastrointestinal motility through a dual mechanism of action. It acts as both a dopamine D2 receptor antagonist and an acetylcholinesterase inhibitor. By blocking dopamine receptors, it removes the inhibitory effect of dopamine on gastrointestinal motility, while its acetylcholinesterase inhibition increases acetylcholine levels, further promoting coordinated gastric contractions and improved gastric emptying.\nTherapeutic Uses and Indications\nESMOSTRUM IT is prescribed for a wide range of gastrointestinal conditions where both acid suppression and enhanced motility are therapeutically beneficial:\nGastroesophageal Reflux Disease (GERD)\nESMOSTRUM IT provides exceptional relief for patients suffering from GERD, a chronic condition where stomach acid frequently flows back into the esophagus. The esomeprazole component reduces acid production, while itopride improves the tone of the lower esophageal sphincter and accelerates gastric emptying, thereby reducing the frequency and severity of reflux episodes.\nFunctional Dyspepsia\nFor patients experiencing persistent or recurrent upper abdominal discomfort without an identifiable organic cause, ESMOSTRUM IT addresses multiple pathophysiological mechanisms. It relieves symptoms such as early satiety, postprandial fullness, epigastric pain, and bloating by normalizing gastric acid levels and improving gastric accommodation and emptying.\nPeptic Ulcer Disease\nESMOSTRUM IT aids in the healing of gastric and duodenal ulcers by creating an optimal healing environment through sustained acid suppression. The prokinetic action of itopride helps prevent stasis of gastric contents, which can exacerbate ulcer symptoms.\nNon-Ulcer Dyspepsia\nMany patients experience dyspeptic symptoms without evidence of ulceration. ESMOSTRUM IT effectively manages these symptoms by addressing both acid hypersecretion and delayed gastric emptying, two key factors in non-ulcer dyspepsia.\nGastroparesis-Related Symptoms\nIn conditions where gastric emptying is significantly delayed, the itopride component of ESMOSTRUM IT helps restore more normal gastric motility patterns, reducing associated symptoms like nausea, vomiting, and abdominal distension.\nKey Benefits and Advantages\nDual Mechanism of Action\nThe primary advantage of ESMOSTRUM IT lies in its comprehensive approach to gastrointestinal health. Rather than addressing only acid production or motility in isolation, this combination therapy tackles both aspects simultaneously, providing more complete symptom relief and better therapeutic outcomes.\nSuperior Acid Suppression\nEsomeprazole offers more consistent and prolonged acid suppression compared to many other acid-reducing medications. It provides sustained relief throughout the day and night, allowing patients to experience fewer breakthrough symptoms and better quality of life.\nEnhanced Gastric Motility\nThe itopride component specifically targets motility issues without crossing the blood-brain barrier significantly, meaning it provides prokinetic benefits with minimal central nervous system side effects. This results in improved gastric emptying, reduced bloating, and decreased feelings of fullness after meals.\nRapid Symptom Relief\nMany patients experience noticeable improvement in their symptoms within the first few days of treatment with ESMOSTRUM IT. The combination therapy addresses multiple symptom pathways simultaneously, leading to faster and more comprehensive relief.\nImproved Quality of Life\nBy effectively managing symptoms such as heartburn, regurgitation, nausea, bloating, and early satiety, ESMOSTRUM IT significantly enhances patients' daily functioning and overall well-being. Patients report better sleep quality, improved dietary tolerance, and reduced anxiety related to their digestive symptoms.\nConvenient Dosing\nThe combination of two active ingredients in a single formulation improves medication adherence by reducing pill burden. Patients appreciate the simplicity of taking one medication instead of multiple separate preparations.\nMucosal Healing Properties\nBeyond symptom relief, ESMOSTRUM IT promotes actual healing of damaged esophageal and gastric mucosa. The reduced acid environment created by esomeprazole allows inflamed and eroded tissue to regenerate properly.\nReduced Risk of Complications\nBy effectively controlling acid reflux and improving gastric emptying, ESMOSTRUM IT helps prevent potential complications of chronic GERD, such as esophageal strictures, Barrett's esophagus, and respiratory complications from aspiration.\nDosage and Administration\nESMOSTRUM IT should be taken exactly as prescribed by a healthcare professional. Typically, the medication is administered orally, preferably before meals to optimize its therapeutic effects. The standard dosing regimen usually involves once or twice daily administration, though individual requirements may vary based on the severity of the condition and patient response.\nThe medication should be swallowed whole with water and should not be crushed, chewed, or split, as this may affect the drug's release mechanism and therapeutic efficacy. Patients should maintain regular dosing schedules to ensure optimal acid suppression and motility enhancement throughout the day.\nSide Effects and Safety Considerations\nLike all medications, ESMOSTRUM IT may cause side effects in some individuals, though not everyone experiences them. Understanding potential adverse effects helps patients identify and report concerning symptoms promptly.\nCommon Side Effects\nGastrointestinal Effects: Some patients may experience diarrhea, constipation, abdominal pain, nausea, or flatulence, particularly during initial treatment. These effects are usually mild and often resolve as the body adjusts to the medication.\nHeadache: Mild to moderate headaches occur in a small percentage of patients and typically diminish with continued use.\nDizziness: Some individuals may experience lightheadedness or dizziness, particularly when standing up quickly.\nDry Mouth: Reduced saliva production may occur, leading to oral dryness and discomfort.\nLess Common Side Effects\nSkin Reactions: Rash, itching, or other dermatological manifestations may develop in sensitive individuals.\nSleep Disturbances: Some patients report insomnia or unusual dreams while taking the medication.\nIncreased Prolactin Levels: Itopride may cause mild elevation in prolactin levels, though clinical manifestations are rare.\nTaste Alterations: Changes in taste perception or metallic taste may occur temporarily.\nSerious Side Effects (Rare)\nWhile uncommon, certain serious adverse effects require immediate medical attention:\n\nSevere allergic reactions including difficulty breathing, facial swelling, or severe skin reactions\nSevere diarrhea that persists or contains blood\nIrregular heartbeat or palpitations\nMuscle weakness or pain\nSeizures or tremors\nSigns of liver problems including jaundice, dark urine, or persistent nausea\n\nLong-Term Considerations\nExtended use of proton pump inhibitors like esomeprazole has been associated with certain risks that patients should discuss with their healthcare providers:\n\nPotential reduction in calcium, magnesium, and vitamin B12 absorption\nSlightly increased risk of bone fractures with prolonged use\nPossible increased susceptibility to certain gastrointestinal infections\nRare cases of kidney problems\n\nRegular monitoring and periodic assessment by healthcare professionals help minimize these risks while maintaining therapeutic benefits.\nPrecautions and Contraindications\nPatients should inform their healthcare provider about all existing medical conditions, particularly liver disease, kidney problems, osteoporosis, low magnesium levels, or any gastrointestinal bleeding. ESMOSTRUM IT may interact with certain medications, including blood thinners, antifungals, HIV medications, and certain antibiotics. A complete medication review ensures safe and effective therapy.\nPregnant or breastfeeding women should only use ESMOSTRUM IT under strict medical supervision, as the safety profile in these populations requires careful consideration of potential risks and benefits.\nLifestyle Recommendations\nFor optimal therapeutic outcomes, patients taking ESMOSTRUM IT should complement their medication regimen with appropriate lifestyle modifications:\n\nAvoid trigger foods that exacerbate acid reflux, such as spicy foods, citrus, chocolate, caffeine, and alcohol\nMaintain a healthy body weight to reduce abdominal pressure\nEat smaller, more frequent meals rather than large portions\nAvoid lying down immediately after eating; wait at least two to three hours\nElevate the head of the bed if nighttime symptoms occur\nQuit smoking, as tobacco use significantly worsens reflux symptoms\nManage stress through relaxation techniques, as stress can exacerbate digestive symptoms\n\nConclusion\nESMOSTRUM IT represents a sophisticated and effective pharmaceutical solution for individuals struggling with complex gastrointestinal disorders involving both acid hypersecretion and impaired motility. By combining the powerful acid-suppressing capabilities of esomeprazole with the prokinetic benefits of itopride, this medication offers comprehensive symptom management that addresses the multifaceted nature of digestive disorders.",
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"description": "GLISITAPTIN 100 is a pharmaceutical formulation containing Sitagliptin Phosphate 100 mg as its active ingredient. This medication represents a significant advancement in the management of type 2 diabetes mellitus, offering patients an effective oral treatment option that works through an innovative mechanism of action. As part of the DPP-4 inhibitor class of antidiabetic medications, GLISITAPTIN 100 has emerged as a trusted choice for healthcare providers and patients seeking reliable glycemic control with a favorable safety profile.\nThe brand name GLISITAPTIN 100 signifies quality, efficacy, and a commitment to helping individuals with type 2 diabetes achieve better health outcomes. Each tablet is precisely formulated to deliver the optimal therapeutic dose of sitagliptin phosphate, ensuring consistent and predictable results in blood sugar management.\nUnderstanding Sitagliptin Phosphate\nSitagliptin phosphate is a highly selective dipeptidyl peptidase-4 (DPP-4) inhibitor that has revolutionized diabetes treatment since its introduction. Unlike older diabetes medications that work through insulin secretion or glucose absorption mechanisms alone, sitagliptin operates through the incretin system—a natural bodily process that regulates blood glucose levels in response to food intake.\nThe 100 mg strength available in GLISITAPTIN 100 represents the standard therapeutic dose for most adult patients, providing optimal efficacy while maintaining an excellent safety margin. This once-daily formulation simplifies treatment regimens and promotes better adherence, which is crucial for long-term diabetes management success.\nHow GLISITAPTIN 100 Works\nGLISITAPTIN 100 works through a sophisticated yet elegant mechanism that harnesses your body's natural glucose regulation system. When you eat, your intestines release hormones called incretins, specifically GLP-1 (glucagon-like peptide-1) and GIP (glucose-dependent insulinotropic polypeptide). These incretins have multiple beneficial effects: they stimulate insulin secretion from the pancreas, suppress glucagon release (which reduces glucose production by the liver), and slow gastric emptying.\nHowever, these beneficial incretins are rapidly broken down by an enzyme called DPP-4, limiting their glucose-lowering effects. GLISITAPTIN 100 inhibits this DPP-4 enzyme, allowing incretins to remain active in your bloodstream for longer periods. This results in better insulin secretion when blood glucose is elevated, reduced glucagon levels, and ultimately improved blood sugar control throughout the day.\nImportantly, because this mechanism is glucose-dependent, GLISITAPTIN 100 primarily works when blood sugar is elevated, which significantly reduces the risk of hypoglycemia (dangerously low blood sugar) compared to some other diabetes medications.\nPrimary Uses and Indications\nType 2 Diabetes Mellitus Management: GLISITAPTIN 100 is primarily indicated for improving glycemic control in adult patients with type 2 diabetes mellitus. It can be prescribed as:\n\nMonotherapy: As a first-line treatment for patients who cannot achieve adequate control through diet and exercise alone, particularly when metformin is contraindicated or not tolerated\nCombination Therapy: Alongside metformin, sulfonylureas, thiazolidinediones, or insulin when these medications alone do not provide sufficient glucose control\nTriple Therapy: In combination with two other antidiabetic agents when dual therapy fails to achieve target HbA1c levels\n\nThe medication is particularly suitable for patients who require effective glucose control but have concerns about weight gain or hypoglycemia, as GLISITAPTIN 100 is weight-neutral and has a low hypoglycemia risk when used as monotherapy.\nKey Benefits of GLISITAPTIN 100\n1. Effective Glycemic Control\nClinical studies have demonstrated that GLISITAPTIN 100 significantly reduces HbA1c levels (a measure of long-term blood sugar control) by approximately 0.5-1.0%, helping patients achieve and maintain target glucose levels. This improvement translates to reduced risk of diabetes-related complications over time.\n2. Low Hypoglycemia Risk\nUnlike sulfonylureas or insulin, GLISITAPTIN 100 has a glucose-dependent mechanism, meaning it primarily works when blood sugar is elevated. This dramatically reduces the risk of hypoglycemic episodes, providing patients with greater safety and peace of mind, especially important for elderly patients or those with unpredictable meal schedules.\n3. Weight Neutral\nGLISITAPTIN 100 does not cause weight gain, a significant advantage over some other diabetes medications like insulin, sulfonylureas, or thiazolidinediones. Maintaining a healthy body weight is crucial for overall diabetes management and cardiovascular health.\n4. Once-Daily Convenience\nThe single daily dose requirement of GLISITAPTIN 100 simplifies treatment regimens, making it easier for patients to maintain adherence. Better adherence directly correlates with improved glycemic control and better long-term outcomes.\n5. Pancreatic Preservation\nBy working through the incretin system, GLISITAPTIN 100 may help preserve pancreatic beta-cell function, potentially slowing the progression of type 2 diabetes. This represents a significant long-term benefit beyond simple glucose control.\n6. Cardiovascular Safety\nClinical trials have demonstrated cardiovascular safety with sitagliptin, an important consideration given that cardiovascular disease is the leading cause of morbidity and mortality in patients with type 2 diabetes.\n7. Renal Dosing Available\nWhile the 100 mg dose is standard, sitagliptin can be adjusted for patients with kidney impairment, making it accessible to a broader patient population, including those with diabetic nephropathy.\n8. Well-Tolerated\nGLISITAPTIN 100 generally has a favorable side effect profile, with most patients experiencing minimal adverse effects, contributing to better quality of life during treatment.\nDosage and Administration\nThe standard recommended dose of GLISITAPTIN 100 is one tablet taken orally once daily, with or without food. The medication can be taken at any time of day, though taking it at the same time daily helps establish a routine and ensures consistent blood levels.\nFor patients with moderate to severe kidney disease, dosage adjustments may be necessary. Your healthcare provider will determine the appropriate dose based on your kidney function tests. It's crucial to follow your doctor's instructions precisely and not adjust your dose without medical guidance.\nPotential Side Effects\nWhile GLISITAPTIN 100 is generally well-tolerated, like all medications, it may cause side effects in some individuals:\nCommon Side Effects (Affecting 1-10% of patients):\n\nUpper respiratory tract infections\nNasopharyngitis (common cold symptoms)\nHeadache\nNausea\nAbdominal pain\nDiarrhea\n\nThese side effects are typically mild and often resolve on their own as your body adjusts to the medication.\nLess Common but Serious Side Effects:\n\nPancreatitis: Severe abdominal pain that may radiate to the back, with or without vomiting, requires immediate medical attention\nSevere Joint Pain: Persistent, severe joint pain has been reported in some patients; inform your doctor if this occurs\nAllergic Reactions: Rare cases of serious allergic reactions including anaphylaxis, angioedema, and severe skin reactions have occurred\nHeart Failure: In patients with existing heart disease, worsening heart failure has been reported\nBullous Pemphigoid: A rare skin condition requiring discontinuation of the medication\n\nWhen Used with Other Diabetes Medications:\nWhen GLISITAPTIN 100 is combined with sulfonylureas or insulin, the risk of hypoglycemia increases. Your doctor may reduce the dose of these medications when adding GLISITAPTIN 100 to your regimen.\nPrecautions and Contraindications\nDo Not Use GLISITAPTIN 100 if:\n\nYou are allergic to sitagliptin or any ingredients in the formulation\nYou have type 1 diabetes or diabetic ketoacidosis\nYou are under 18 years of age (safety and efficacy not established)\n\nUse with Caution if:\n\nYou have a history of pancreatitis\nYou have kidney disease (dose adjustment required)\nYou have heart failure\nYou are pregnant or planning to become pregnant\nYou are breastfeeding\n\nImportant Patient Information\nMonitoring: Regular monitoring of blood glucose levels and HbA1c testing (typically every 3-6 months) is essential to assess treatment effectiveness and make necessary adjustments.\nLifestyle Factors: GLISITAPTIN 100 works best when combined with a healthy diet, regular physical activity, and weight management. Medication alone cannot substitute for comprehensive lifestyle management.\nMissed Dose: If you miss a dose, take it as soon as you remember on the same day. If it's almost time for your next dose, skip the missed dose and continue with your regular schedule. Never double up doses.\nStorage: Store GLISITAPTIN 100 at room temperature, away from moisture and heat. Keep the medication in its original container and out of reach of children.\nDrug Interactions\nGLISITAPTIN 100 has few significant drug interactions, contributing to its safety profile. However, inform your healthcare provider about all medications, supplements, and herbal products you're taking. Particular attention should be paid to:\n\nOther diabetes medications (may require dose adjustments)\nDigoxin (levels may be slightly increased)\nMedications affecting kidney function\n\nConclusion\nGLISITAPTIN 100 (Sitagliptin Phosphate 100 mg) represents a modern, effective, and well-tolerated option for managing type 2 diabetes mellitus. Its innovative mechanism through the incretin system offers multiple advantages including effective glucose control, low hypoglycemia risk, weight neutrality, and once-daily convenience. These benefits make it an excellent choice for many patients, whether used alone or in combination with other antidiabetic medications.",
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"name": "Cinnarizine and Domperidone Tablets ",
"description": "CLANARIZINE DOM represents an advanced pharmaceutical combination that brings together two potent therapeutic agents—Cinnarizine and Domperidone—in a single convenient tablet formulation. This innovative combination medication addresses multiple aspects of vestibular disorders, motion sickness, and associated nausea and vomiting, providing comprehensive relief for patients suffering from these debilitating conditions. Manufactured under stringent quality control standards, CLANARIZINE DOM offers a synergistic approach to managing symptoms that significantly impact quality of life and daily functioning.The combination of Cinnarizine and Domperidone in CLANARIZINE DOM is based on sound pharmacological principles. While Cinnarizine works primarily on the vestibular system to reduce dizziness and vertigo, Domperidone acts as an effective antiemetic to control nausea and vomiting. Together, these two active ingredients provide more comprehensive symptom control than either agent alone, making CLANARIZINE DOM an excellent choice for patients experiencing vestibular disturbances accompanied by gastrointestinal symptoms.This combination therapy is particularly valuable because vertigo, dizziness, and motion sickness are frequently accompanied by nausea and vomiting. Patients suffering from these conditions often find that addressing only one aspect of their symptoms provides insufficient relief. CLANARIZINE DOM's dual-action formula tackles both the underlying vestibular dysfunction and the accompanying gastrointestinal distress, offering patients a more complete therapeutic solution that improves both comfort and functional capacity.Understanding the Active IngredientsCinnarizine is a calcium channel blocker with specific antihistaminic and vestibular suppressant properties. Unlike systemic calcium channel blockers used for cardiovascular conditions, Cinnarizine selectively acts on the blood vessels in the inner ear and brain, improving blood flow to these areas. This enhanced circulation helps reduce the frequency and severity of vertigo attacks while also preventing motion sickness. Cinnarizine also possesses mild antihistaminic effects that contribute to its anti-nausea properties, though this is not its primary mechanism of action.The medication works by blocking calcium channels in the vestibular system, which helps stabilize the sensory organs responsible for balance. By reducing the excessive stimulation of the vestibular apparatus, Cinnarizine decreases the sensation of spinning or imbalance that characterizes vertigo. Additionally, its vasodilatory effects improve microcirculation in the inner ear, which can be beneficial for conditions where reduced blood flow contributes to symptoms.Domperidone is a peripheral dopamine antagonist that acts primarily as a prokinetic and antiemetic agent. Unlike some antiemetic medications that cross the blood-brain barrier and cause sedation or extrapyramidal side effects, Domperidone works predominantly in the peripheral nervous system. It blocks dopamine receptors in the chemoreceptor trigger zone (CTZ) located outside the blood-brain barrier, effectively preventing nausea and vomiting without causing significant central nervous system effects.Domperidone also enhances gastrointestinal motility by promoting coordinated contractions of the stomach and upper small intestine. This prokinetic effect helps empty the stomach more efficiently, reducing feelings of fullness, bloating, and discomfort that often accompany vestibular disorders. By accelerating gastric emptying, Domperidone also reduces the likelihood of gastroesophageal reflux, which can exacerbate nausea in some patients.The combination of these two medications in CLANARIZINE DOM creates a complementary therapeutic effect. While Cinnarizine addresses the vestibular component of dizziness and vertigo, Domperidone manages the gastrointestinal symptoms that frequently accompany these conditions. This dual approach provides more comprehensive symptom relief and improves overall treatment outcomes compared to monotherapy with either agent alone.Clinical Applications and UsesCLANARIZINE DOM is indicated for a wide range of conditions characterized by vertigo, dizziness, and associated nausea. Understanding these clinical applications helps healthcare providers select appropriate candidates for this combination therapy.Vestibular Disorders: The primary indication for CLANARIZINE DOM includes various vestibular disorders that cause vertigo and imbalance. These conditions include Ménière's disease, benign paroxysmal positional vertigo (BPPV), vestibular neuritis, and labyrinthitis. Patients with these disorders experience episodes of spinning sensation, loss of balance, and often severe nausea. CLANARIZINE DOM helps reduce the frequency and intensity of vertigo attacks while controlling the accompanying gastrointestinal symptoms.Motion Sickness: CLANARIZINE DOM is highly effective for preventing and treating motion sickness, whether related to travel by car, boat, airplane, or amusement park rides. The medication can be taken prophylactically before travel or at the onset of symptoms. The combination is particularly useful for individuals who experience severe nausea and vomiting with motion sickness, as Domperidone provides powerful antiemetic effects that complement Cinnarizine's anti-motion-sickness properties.Migraine-Associated Vertigo: Many patients with migraines experience vestibular symptoms, including dizziness, vertigo, and motion sensitivity, either during migraine attacks or as independent episodes. CLANARIZINE DOM can help manage these vestibular manifestations of migraine, reducing both the vertigo and the nausea that often accompany migraine headaches.Post-Concussion Syndrome: Following head injuries, some patients develop persistent dizziness, balance problems, and nausea as part of post-concussion syndrome. CLANARIZINE DOM may provide symptomatic relief for these patients during their recovery period, though it should be used as part of a comprehensive treatment approach that includes rest, gradual return to activities, and vestibular rehabilitation when appropriate.Cerebrovascular Insufficiency: In older adults with reduced blood flow to the brain, symptoms such as dizziness, vertigo, tinnitus (ringing in the ears), and cognitive difficulties may develop. Cinnarizine's vasodilatory properties can improve cerebral circulation, potentially reducing these symptoms. The addition of Domperidone helps manage any associated nausea.Radiation-Induced or Chemotherapy-Induced Nausea: While not a primary indication, some healthcare providers use CLANARIZINE DOM as adjunctive therapy for patients undergoing cancer treatment who experience both nausea and dizziness. Domperidone's strong antiemetic properties are particularly valuable in this context.Key Benefits of CLANARIZINE DOMThe unique combination of Cinnarizine and Domperidone in CLANARIZINE DOM offers numerous advantages that make it a preferred choice for managing vestibular disorders and associated symptoms.Comprehensive Symptom Control: The primary benefit of CLANARIZINE DOM is its ability to address multiple symptoms simultaneously. Rather than requiring patients to take separate medications for vertigo and nausea, this combination provides unified treatment in a single tablet. This comprehensive approach improves symptom control across the full spectrum of vestibular disorder manifestations, from the spinning sensation to the gastrointestinal distress that often accompanies it.Improved Patient Compliance: Taking multiple medications can be burdensome, particularly for patients who feel dizzy or nauseated. CLANARIZINE DOM simplifies the treatment regimen by combining two medications in one tablet, making it easier for patients to adhere to their prescribed therapy. Better compliance translates to better outcomes, as consistent medication use is essential for managing chronic vestibular conditions.Synergistic Therapeutic Effects: The combination of Cinnarizine and Domperidone creates synergistic effects that enhance overall efficacy. While Cinnarizine reduces vestibular stimulation and improves inner ear blood flow, Domperidone prevents nausea and promotes gastric emptying. This dual action addresses both the cause and consequences of vestibular dysfunction, providing more complete relief than either medication alone.Reduced Central Nervous System Side Effects: Because Domperidone works primarily in the peripheral nervous system rather than crossing the blood-brain barrier extensively, CLANARIZINE DOM causes less sedation and fewer cognitive effects compared to some alternative antiemetic medications. This allows patients to maintain better alertness and function during treatment, which is particularly important for those who need to continue working or performing daily activities.Enhanced Quality of Life: Vertigo and chronic dizziness significantly impair quality of life, limiting mobility, social interactions, and occupational functioning. The nausea and vomiting that accompany these conditions add another layer of disability. By effectively controlling both vestibular and gastrointestinal symptoms, CLANARIZINE DOM helps restore patients' ability to engage in normal activities, improving overall life satisfaction and functional independence.Fast Onset of Action: CLANARIZINE DOM provides relatively rapid symptom relief, with many patients experiencing improvement within 30 minutes to 2 hours after taking the medication. This quick onset is particularly valuable for acute episodes of vertigo or when taking the medication prophylactically before situations that might trigger motion sickness.Suitable for Long-Term Use: For patients with chronic vestibular disorders requiring ongoing treatment, CLANARIZINE DOM is generally safe for extended use when properly monitored by a healthcare provider. The medication maintains its effectiveness over time without significant tolerance development, making it suitable for long-term symptom management.Improved Gastric Emptying: The prokinetic effects of Domperidone benefit not only nausea but also other gastrointestinal symptoms such as early satiety, bloating, and upper abdominal discomfort. Patients with vestibular disorders often develop gastroparesis or delayed gastric emptying secondary to their condition, and Domperidone addresses this issue effectively.Vascular Benefits: Cinnarizine's ability to improve blood flow to the inner ear and brain provides additional benefits beyond symptom control. Enhanced microcirculation may support healing and recovery in conditions where vascular insufficiency contributes to vestibular dysfunction.Side Effects and Safety ConsiderationsLike all medications, CLANARIZINE DOM can cause side effects, though not everyone experiences them. Understanding potential adverse effects helps patients recognize when to seek medical attention and allows healthcare providers to monitor therapy appropriately.Common Side Effects:The most frequently reported side effect of CLANARIZINE DOM is drowsiness or sedation, occurring in approximately 10-20% of patients. This effect is primarily attributable to Cinnarizine's antihistaminic properties. Patients should avoid driving or operating machinery until they know how the medication affects them. Taking the medication at bedtime can minimize daytime drowsiness for some patients.Dry mouth is another common side effect, affecting roughly 10-15% of patients. This occurs due to anticholinergic effects and can be managed by sipping water frequently, chewing sugar-free gum, or using saliva substitutes if severe. Maintaining good oral hygiene is important to prevent dental problems associated with reduced saliva production.Mild gastrointestinal symptoms, including constipation, abdominal discomfort, or changes in bowel habits, may occur. While Domperidone promotes gastric emptying, it can occasionally alter bowel motility. These effects are usually mild and resolve with continued use or dose adjustment.",
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"name": "Frusemide IP 40mg ",
"description": "FRUSIP 40 is a pharmaceutical formulation containing Frusemide IP 40mg as its active ingredient, presented in tablet form for oral administration. This medication belongs to the class of loop diuretics, which are among the most potent diuretic agents available in modern medicine. FRUSIP 40 is specifically designed to help manage conditions associated with fluid retention and elevated blood pressure, offering patients a reliable therapeutic solution for maintaining optimal fluid balance in the body.\nThe formulation adheres to Indian Pharmacopoeia (IP) standards, ensuring consistent quality, purity, and efficacy. Each tablet is precisely manufactured to deliver the exact dosage required for effective treatment while maintaining the highest safety standards in pharmaceutical production.\nUnderstanding Furosemide and Its Mechanism\nFrusemide, also known as furosemide in some regions, is a powerful loop diuretic that works primarily in the kidneys. The medication exerts its therapeutic effect by inhibiting the reabsorption of sodium and chloride in the ascending loop of Henle, a specific segment of the kidney's nephron. This action prevents the body from retaining excess salt and water, leading to increased urine production and the subsequent elimination of accumulated fluids.\nThe “loop” designation comes from the specific site of action within the kidney's loop of Henle, making frusemide significantly more potent than thiazide diuretics that work in different parts of the kidney. This enhanced potency makes FRUSIP 40 particularly valuable in managing conditions requiring substantial fluid removal.\nPrimary Uses and Indications\nFRUSIP 40 is prescribed for various medical conditions where fluid accumulation poses health risks or causes discomfort:\nEdema Management: The medication is highly effective in treating edema (swelling) associated with congestive heart failure, where the heart's reduced pumping efficiency leads to fluid buildup in the lungs, legs, and other tissues. It helps alleviate breathing difficulties and reduces the strain on the cardiovascular system.\nLiver Disease: Patients with cirrhosis or other liver conditions often develop ascites, an accumulation of fluid in the abdominal cavity. FRUSIP 40 helps manage this uncomfortable and potentially dangerous condition by promoting fluid elimination.\nKidney Disorders: In cases of nephrotic syndrome and other renal conditions causing fluid retention, this medication assists in maintaining proper fluid balance, though it must be used judiciously under medical supervision in patients with compromised kidney function.\nHypertension Control: FRUSIP 40 serves as an effective antihypertensive agent, helping to lower blood pressure by reducing blood volume through increased fluid excretion. This is particularly beneficial for patients whose hypertension is resistant to other treatments.\nPulmonary Edema: In acute situations where fluid accumulates in the lungs, this medication can provide rapid relief, making it a valuable tool in emergency medical settings.\nKey Benefits and Therapeutic Advantages\nThe advantages of FRUSIP 40 extend beyond its primary diuretic function, offering patients multiple therapeutic benefits:\nRapid Onset of Action: One of the most significant advantages is the quick response time. Patients typically experience diuretic effects within 30 to 60 minutes of oral administration, with peak effects occurring within one to two hours. This rapid action is particularly valuable in acute situations requiring prompt fluid removal.\nPotent Efficacy: As a loop diuretic, FRUSIP 40 demonstrates superior diuretic potency compared to thiazide diuretics, making it the preferred choice for patients with severe fluid retention or those who haven't responded adequately to milder diuretics.\nCardiovascular Protection: By reducing fluid overload, the medication decreases the workload on the heart, helping to prevent complications in patients with heart failure. This protective effect can significantly improve quality of life and potentially reduce hospitalizations.\nSymptom Relief: Patients often experience notable improvement in symptoms such as shortness of breath, swelling in the extremities, and abdominal distension. This symptomatic relief contributes to enhanced mobility and daily functioning.\nFlexible Dosing: The 40mg strength allows healthcare providers to adjust treatment according to individual patient needs, either maintaining this dose or modifying it based on therapeutic response and tolerance.\nElectrolyte Management: When used under proper medical supervision with appropriate monitoring, the medication allows for controlled fluid management while maintaining awareness of electrolyte balance.\nPotential Side Effects and Considerations\nWhile FRUSIP 40 is generally well-tolerated, patients should be aware of potential side effects:\nCommon Side Effects: These include increased urination frequency (which is expected), dizziness or lightheadedness upon standing (due to reduced blood volume), muscle cramps, and mild headaches. These effects often diminish as the body adjusts to the medication.\nElectrolyte Imbalances: The medication can cause depletion of important electrolytes, including potassium, sodium, magnesium, and calcium. Symptoms may include weakness, irregular heartbeat, confusion, or severe muscle cramps. Regular monitoring through blood tests is essential.\nDehydration Risk: Excessive fluid loss can lead to dehydration, characterized by extreme thirst, dry mouth, decreased urine output, and confusion. Patients must maintain adequate fluid intake as directed by their healthcare provider.\nMetabolic Effects: Some patients may experience increased blood sugar levels, elevated uric acid (potentially triggering gout attacks), or changes in cholesterol levels.\nHearing Changes: Rarely, particularly at higher doses, patients may experience ringing in the ears (tinnitus) or temporary hearing impairment.\nPhotosensitivity: Increased sensitivity to sunlight may occur, requiring appropriate sun protection measures.\nDrug Interactions: FRUSIP 40 can interact with numerous medications, including certain antibiotics, other blood pressure medications, NSAIDs, and lithium, necessitating comprehensive medication review by healthcare providers.\nImportant Safety Information\nPatients taking FRUSIP 40 should inform their healthcare provider about any existing medical conditions, particularly kidney disease, liver disease, diabetes, gout, or lupus. Pregnant and breastfeeding women require special consideration, as the medication crosses the placenta and appears in breast milk.\nRegular monitoring of kidney function, electrolyte levels, and blood pressure is essential for safe and effective therapy. Patients should maintain consistent communication with their healthcare team and report any unusual symptoms promptly.\nConclusion\nFRUSIP 40 (Frusemide IP 40mg Tablets) represents a cornerstone therapy in the management of conditions involving fluid retention and hypertension. Its potent diuretic action, rapid onset, and proven efficacy make it an invaluable tool in cardiovascular and renal medicine. The medication offers significant benefits in symptom relief, cardiovascular protection, and overall quality of life improvement for patients struggling with edema and related conditions.\nHowever, the power of this medication demands respect and proper medical supervision. The potential for electrolyte imbalances and other side effects necessitates regular monitoring and open communication between patients and healthcare providers. When used appropriately under medical guidance, with proper monitoring and patient education, FRUSIP 40 can dramatically improve patient outcomes and help individuals regain control over conditions that significantly impact their daily lives.\nPatients prescribed FRUSIP 40 should view this medication as part of a comprehensive treatment plan that may include dietary modifications, lifestyle changes, and other medications. Success with this therapy depends on adherence to prescribed dosing, regular follow-up appointments, and proactive management of potential side effects. With proper use, FRUSIP 40 continues to serve as a trusted and effective therapeutic option for millions of patients worldwide requiring diuretic therapy.",
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