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"description": "Enzalutamide 40 mg capsules represent a breakthrough in targeted therapy for advanced prostate cancer, particularly in metastatic castration-resistant prostate cancer (mCRPC) and metastatic castration-sensitive prostate cancer (mCSPC). This second-generation androgen receptor inhibitor works by disrupting multiple steps in the androgen signaling pathway, offering patients a chance to slow disease progression, reduce tumor burden, and extend survival even after other treatments fail. Administered as a once-daily oral capsule, enzalutamide 40 mg provides four capsules per day (total 160 mg), making it convenient for long-term use in clinical settings where hormone therapy alone proves insufficient.\n\nPatients often turn to enzalutamide when facing rising PSA levels despite androgen deprivation therapy (ADT), experiencing bone pain, or dealing with cancer spread to lymph nodes or distant sites. Its high affinity for androgen receptors—5-8 times stronger than first-generation antiandrogens like bicalutamide—ensures potent blockade without agonist activity, translating to real-world benefits like delayed chemotherapy needs and improved quality of life during treatment.\n\nProduct Use and Indications\nEnzalutamide 40 mg primarily treats metastatic castration-resistant prostate cancer (mCRPC) in patients previously treated with docetaxel or progressing despite ADT. The FDA and EMA approvals extend to non-metastatic CRPC (nmCRPC) with high-risk biochemical recurrence and metastatic castration-sensitive prostate cancer (mCSPC) alongside ADT, based on landmark trials like AFFIRM, PREVAIL, PROSPER, and ARCHES.\n\nKey uses include:\n\nSlowing tumor growth in hormone-refractory stages by inhibiting androgen-driven proliferation.\n\nReducing skeletal-related events like fractures or spinal cord compression in bone metastases.\n\nDelaying progression to chemotherapy in pre-chemotherapy mCRPC, with PREVAIL showing 17-month median radiographic progression-free survival (rPFS) versus 4 months for placebo.\n\nIn mCSPC, ARCHES trial data demonstrated 61% risk reduction in progression or death when combined with ADT. Clinicians monitor PSA response (≥50% decline in 70-80% of patients) and imaging every 3 months to assess efficacy.\n\nMechanism of Action\nEnzalutamide 40 mg exerts a threefold blockade on androgen receptor (AR) signaling: it competitively inhibits androgen binding to AR (with affinity rivaling dihydrotestosterone), prevents nuclear translocation of the ligand-receptor complex, and disrupts DNA binding and coactivator recruitment at androgen response elements. This comprehensive inhibition downregulates oncogenes like TMPRSS2-ERG fusion genes common in prostate cancer, inducing apoptosis and halting cell proliferation without lowering systemic testosterone levels.\n\nUnlike earlier antiandrogens, enzalutamide avoids partial agonist effects, ensuring pure antagonism even in AR-overexpressing tumors. Its active metabolite, N-desmethyl enzalutamide (via CYP2C8), contributes 30% to activity, with steady-state levels achieved in 4 weeks.\n\nKey Benefits\nExtended Progression-Free Survival: In PREVAIL (pre-chemo mCRPC), median overall survival reached 32.4 months versus 30.2 for placebo; PROSPER (nmCRPC) delayed metastasis by 22 months.\n\nPSA Response and Tumor Shrinkage: 78% PSA90 response rate; radiographic responses in 29% with measurable disease.\n\nQuality of Life Preservation: Delays pain progression (hazard ratio 0.40) and chemotherapy (by 17 months), maintaining daily function.\n\nBone Protection: Reduces fractures by 30% in high-risk patients via AR inhibition in osteoblasts.\n\nCombination Synergy: Enhances ADT efficacy in mCSPC, cutting death risk by 33% per ARCHES.\n\nThese benefits position enzalutamide 40 mg as a cornerstone in modern prostate cancer protocols, especially for fit patients tolerating oral therapy.\n\nSide Effects\nEnzalutamide 40 mg carries a manageable profile, with most effects dose-related and reversible upon discontinuation.\n\nCommon Side Effects\nFatigue/Asthenia (34-50%): Often mild, peaking in first months; rest and nutrition help.\n\nArthralgia/Myalgia (14-21%): Joint/muscle pain managed with NSAIDs.\n\nHot Flashes (20%): Androgen blockade mimic; hydration aids.\n\nHeadache/Dizziness (12-19%): Transient; avoid driving if severe.\n\nHypertension (6-13%): Monitor BP monthly; antihypertensives as needed.\n\nGI Issues (diarrhea 12%, nausea 11%): Antiemetics support compliance.\n\nSerious Side Effects\nSeizures (0.9%): Highest risk in epileptics or brain mets; EEG baseline, avoid triggers.\n\nPosterior Reversible Encephalopathy (PRES): Rare (<0.1%); headache, confusion—MRI confirms.\n\nFalls/Fractures (15% increased risk): Due to weakness/falls; DEXA scans recommended.\n\nCardiac Events (2-5%): MI/arrhythmias; ECG monitoring in CVD history.\n\nHepatic Injury (1%): ALT/AST elevation; monthly labs first 3 months.\n\nDiscontinuation occurs in 8-10%; supportive care mitigates most.\n\nDosage and Administration\nStandard dose: 160 mg (four 40 mg capsules) once daily, with or without food. Swallow intact; no crushing. Adjust for CYP2A4 inducers (e.g., rifampin—increase to 240 mg) or strong inhibitors (reduce to 80 mg). Continue until progression/toxicity; no dose interruptions beyond 28 days without reassessment.\n\nPrecautions and Monitoring\nContraindicated in pregnancy (teratogenic; absolute contraception for men/ partners). Screen for seizure history; CYP2C8/3A4 interactions (e.g., ketoconazole). Baseline LFTs, PSA, testosterone; imaging q8-12 weeks. Elderly (>75) monitor falls.\nConclusion\nEnzalutamide 40 mg stands as a transformative therapy, empowering prostate cancer patients with prolonged control over aggressive disease through precise AR inhibition. Balancing robust efficacy—evidenced by landmark trials delaying metastasis and death—with proactive side effect management, it enhances survival and daily living. Patients achieve meaningful milestones, from family events to travel, underscoring its role in personalized oncology. Consult oncologists for integration into care plans, ensuring optimal outcomes in this challenging journey.\nEmail: info@sterispharma.com / contact@sterispharma.com\nCall/WhatsApp: 7877551268, 7849827488\n\n\n\n\n\n\n\n\n",
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"name": "Nebivolol and s-amlodipine Tablets 5/2.5 mg",
"description": "NEBIVALVE AM is a combination tablet containing Nebivolol and S-Amlodipine, designed to provide effective management of hypertension (high blood pressure). Hypertension is a leading risk factor for cardiovascular diseases in India, including heart attacks, strokes, and kidney complications.\n\nThis dual-action formulation combines the benefits of Nebivolol, a cardio-selective beta-blocker, with S-Amlodipine, a calcium channel blocker, providing comprehensive blood pressure control. The combination helps relax blood vessels, improve blood flow, and reduce cardiac workload, offering a convenient and effective option for patients requiring combination therapy.\n\nUses\n\nNEBIVALVE AM is primarily prescribed for:\n\nEssential Hypertension\nLowers elevated blood pressure to reduce the risk of cardiovascular complications.\n\nCardiovascular Risk Reduction\nHelps in preventing heart attacks, strokes, and heart failure in high-risk patients.\n\nManagement of Stable Angina\nBy reducing cardiac workload and improving oxygen supply to the heart.\n\nCombination Therapy in Resistant Hypertension\nSuitable for patients who do not achieve target blood pressure with single-drug therapy.\n\nBenefits\n1. Dual Mechanism of Action\n\nNebivolol: Blocks beta-1 adrenergic receptors in the heart, reducing heart rate and cardiac output. It also promotes nitric oxide release, helping dilate blood vessels.\n\nS-Amlodipine: Relaxes vascular smooth muscles by blocking calcium channels, improving blood flow and reducing blood pressure.\n\n2. Effective Blood Pressure Control\n\nThe combination provides better blood pressure reduction compared to either drug alone, helping patients achieve their target levels faster.\n\n3. Cardiovascular Protection\n\nReduces strain on the heart, lowers risk of stroke, and supports overall heart health.\n\n4. Once-Daily Convenience\n\nThe tablet can be taken once daily, enhancing patient adherence to therapy.\n\n5. Well-Tolerated Formulation\n\nBoth Nebivolol and S-Amlodipine are generally well tolerated, minimizing side effects when used as prescribed.\n\nDosage\n\nTypical Dose: One tablet of NEBIVALVE AM once daily, preferably at the same time each day.\n\nAdministration: Swallow the tablet whole with water. Do not crush or chew.\n\nIndividualization: The dose may be adjusted by the physician based on blood pressure response and patient tolerability.\n\nLifestyle Measures: Continue dietary modifications, regular exercise, and salt restriction alongside medication for optimal results.\n\nImportant: Do not stop the medication abruptly without consulting your doctor, as sudden withdrawal may worsen blood pressure control or cardiac function.\n\nSide Effects\n\nNEBIVALVE AM is generally well tolerated, but some patients may experience mild side effects, including:\n\nDizziness or lightheadedness\n\nFatigue or weakness\n\nHeadache\n\nFlushing or swelling of ankles (edema)\n\nMild gastrointestinal discomfort\n\nRare but Serious Side Effects\n\nSlow heart rate (bradycardia)\n\nSevere hypotension (low blood pressure)\n\nWorsening of heart failure in susceptible patients\n\nAllergic reactions such as rash or swelling\n\nSeek immediate medical attention if severe symptoms such as fainting, chest pain, or shortness of breath occur.\n\nPrecautions and Warning\n\nPregnancy and Breastfeeding: Use only if clearly indicated and prescribed by a doctor.\n\nHeart Conditions: Inform your doctor if you have heart failure, arrhythmia, or recent heart attack.\n\nKidney or Liver Impairment: Dose adjustment may be necessary.\n\nDiabetes: Nebivolol may mask symptoms of low blood sugar; monitor blood glucose closely.\n\nDrug Interactions: Notify your doctor about all medications, especially other blood pressure drugs, anti-arrhythmics, or diuretics.\n\nAvoid Alcohol: Alcohol may increase the risk of hypotension or dizziness.\n\nRegular Monitoring: Blood pressure and heart rate should be monitored periodically during therapy.\n\nConclusion\n\nNEBIVALVE AM (Nebivolol and S-Amlodipine Tablets) is a safe and effective combination therapy for managing hypertension and reducing cardiovascular risks. By combining Nebivolol’s beta-blocking and vasodilatory effects with S-Amlodipine’s calcium channel blocking action, it provides superior blood pressure control and cardiovascular protection.",
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"name": "Naltrexone Hydrochloride IP 50 mg",
"description": "Naltrexone Hydrochloride IP 50 mg, marketed under the brand name NALTREXON 50, is a prescription medication primarily used in the management of opioid and alcohol dependence. This potent pharmaceutical agent plays a crucial role in addiction treatment programs by helping individuals reduce or eliminate their reliance on addictive substances. Below is an in-depth description of the product, its uses, key benefits, possible side effects, and a concluding overview.\n\nProduct Description\nNALTREXON 50 contains Naltrexone Hydrochloride as its active ingredient, formulated as an immediate-release tablet with a strength of 50 mg per tablet. Naltrexone is an opioid antagonist, meaning it works by blocking the opioid receptors in the brain. By binding to these receptors without activating them, Naltrexone prevents opioids from producing their euphoric and sedative effects, which are often responsible for addiction.\nPharmacologically, Naltrexone Hydrochloride belongs to the class of medications known as opioid antagonists, specifically targeting mu, kappa, and delta opioid receptors. Its chemical composition and formulation comply with the Indian Pharmacopoeia (IP) standards, ensuring high quality and purity that meet regulatory guidelines.\n\nNALTREXON 50 is indicated for adults who are already detoxified from opioids or alcohol and are motivated to maintain abstinence from these substances. It supports addiction recovery by reducing cravings and diminishing the rewarding effects if relapse occurs.\n\nUses of NALTREXONE 50\nNALTREXONE 50 is primarily prescribed for two major therapeutic purposes:\n\nAlcohol dependence management: It helps reduce the desire to consume alcohol and lowers the risk of relapse by blocking alcohol’s rewarding effects in the brain.\n\nOpioid dependence treatment: Naltrexone aids in preventing relapse by blocking the euphoric and sedative effects induced by opioid drugs like heroin, morphine, and prescription painkillers.\n\nThe medication is typically administered as part of a comprehensive addiction treatment plan that includes counseling, behavioral therapies, and support groups. It is essential that the patient is opioid-free for at least 7 to 10 days before starting Naltrexone to avoid precipitating withdrawal symptoms.\n\nKey Benefits\nReduces cravings and relapse: By blocking opioid receptors, NALTREXON 50 reduces cravings and diminishes the pleasure derived from alcohol or opioid consumption, which helps patients stay abstinent.\n\nNon-addictive: Unlike some addiction treatments that contain opioids, Naltrexone is non-addictive and does not produce tolerance or dependence.\n\nSupports long-term recovery: When combined with behavioral therapy, Naltrexone enhances the likelihood of successful long-term abstinence from alcohol and opioids.\n\nImproves quality of life: Patients taking NALTREXONE 50 often experience improved emotional stability, better social functioning, and enhanced physical health compared to ongoing substance use.\n\nOral administration: As an oral tablet, Naltrexone is easy to administer, improving patient compliance.\n\nReduces overdose risk: By blocking the euphoric effects of opioids, it reduces the temptation to use high doses, thereby decreasing the risk of overdose.\n\nSide Effects\nLike all medications, NALTREXON 50 can cause side effects, although not everyone experiences them. Common side effects associated with Naltrexone Hydrochloride include:\n\nNausea and vomiting: These digestive issues are most frequent during the initial treatment phase but often subside with continued use.\n\nHeadache: Mild to moderate headaches may occur.\n\nDizziness and fatigue: Some patients report feeling dizzy or tired, particularly in the beginning.\n\nInsomnia: Difficulty sleeping or altered sleep patterns may be experienced.\n\nAnxiety or nervousness: Some individuals may feel anxious or agitated.\n\nJoint or muscle pain: Muscle aches and joint discomfort can occasionally occur.\n\nLiver function changes: Very rarely, Naltrexone may lead to elevations in liver enzymes; therefore, monitoring liver function tests during treatment is recommended.\n\nSevere side effects or allergic reactions are uncommon but require immediate medical attention. These include symptoms such as rash, swelling, difficulty breathing, or severe abdominal pain.\n\nIt is crucial for patients to inform their healthcare provider about any pre-existing liver conditions, prescribed or over-the-counter medications, and any history of opioid- or alcohol-related health issues before starting therapy.\n\nConclusion\nNALTREXON 50, containing Naltrexone Hydrochloride IP 50 mg, is a highly effective medication designed to aid in the treatment of alcohol and opioid dependence. Its action as an opioid antagonist helps block the pleasurable effects of these substances, reduce cravings, and diminish relapse risks. When used responsibly as part of a multidisciplinary treatment approach that incorporates counseling and behavioral therapies, NALTREXON 50 significantly enhances the chances of sustained recovery and improved quality of life.\n\nThough generally well-tolerated, users should be aware of potential side effects and consult healthcare providers regularly to ensure safety throughout the course of treatment. With careful medical oversight and patient commitment, NALTREXON 50 is a valuable tool in the fight against substance dependence, offering hope for individuals seeking freedom from addiction.",
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"description": "OVOCYST M is a specialized sustained-release tablet combining Myoinositol 600mg and Metformin SR 500mg, primarily designed to address polycystic ovary syndrome (PCOS) and related metabolic issues in women. This formulation from Steris Healthcare Pvt Ltd targets insulin resistance, hormonal imbalances, and ovulatory dysfunction, making it a go-to option for restoring reproductive wellness. By improving insulin sensitivity and ovarian function, OVOCYST M supports regular cycles and fertility outcomes effectively.\n\nProduct Composition and Mechanism\nOVOCYST M features Myoinositol 600mg, a natural insulin signaling mediator that enhances cellular health and oocyte quality in PCOS patients. Paired with Metformin SR 500mg, a sustained-release biguanide that lowers hepatic glucose production and boosts peripheral insulin uptake, this duo tackles root causes like hyperinsulinemia. The SR technology ensures gradual release, minimizing digestive upset while providing prolonged metabolic support throughout the day.\n\nThis synergistic action restores ovulatory cycles by balancing hormones such as FSH and LH, reducing androgen excess common in PCOS. Women experiencing anovulation or irregular menses find OVOCYST M particularly beneficial as it promotes follicular development without aggressive interventions.\n\nKey Uses of OVOCYST M\nOVOCYST M excels in managing PCOS symptoms, including irregular menstrual cycles and infertility linked to insulin resistance. Healthcare providers often prescribe it for hyperandrogenism, where elevated male hormones cause hirsutism or acne, alongside metabolic syndrome features like obesity.\n\nSupports fertility treatments by improving egg quality and implantation rates in assisted reproduction.\nAids weight management in PCOS by curbing insulin-driven fat accumulation.\nRegulates blood sugar in prediabetic women with PCOS, preventing progression to type 2 diabetes.\nTypically taken once or twice daily with meals, the dosage aligns with physician guidance for optimal results over 4-12 weeks.\n\nMajor Benefits for PCOS and Beyond\nOne standout advantage of OVOCYST M is its ability to normalize ovulation, with studies showing improved cycle regularity in up to 70-80% of users. By enhancing insulin sensitivity, it reduces hyperinsulinemia, alleviating symptoms like fatigue and cravings that hinder daily life.\n\nPromotes modest weight loss (2-5kg over months) through better metabolic control, boosting self-esteem and mobility.\n\nEnhances fertility by maturing oocytes and lowering miscarriage risks in PCOS pregnancies.\n\nLowers androgen levels, clearing skin issues and reducing unwanted hair growth for aesthetic and emotional relief.\n\nLong-term use under supervision sustains these gains, fostering holistic health improvements like better energy and mood stability.\n\nPotential Side Effects and Precautions\nWhile generally well-tolerated, OVOCYST M may cause mild gastrointestinal effects such as nausea, flatulence, or a metallic taste from Metformin. These often subside with time or food intake, thanks to the SR formulation's gentler profile.\n\nRare but serious risks include lactic acidosis in those with kidney/liver issues, warranting avoidance in such cases. Precautions involve monitoring blood sugar, avoiding during acute illnesses, and consulting doctors if pregnant or breastfeeding.\n\nCommon: Bloating or diarrhea, manageable by starting low dose.\n\nConsult promptly for persistent vomiting or weakness.\n\nConclusion\nOVOCYST M stands as a reliable, science-backed ally for women battling PCOS, insulin resistance, and fertility hurdles through its potent Myoinositol 600mg and Metformin SR 500mg blend. Delivering tangible benefits like restored cycles, weight control, and enhanced conception chances, it empowers proactive reproductive health management. Always pair with lifestyle tweaks like balanced diet and exercise for peak efficacy, and rely on professional oversight for safe, sustained results—transforming challenges into opportunities for vitality.",
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"name": "Lurasidone Hydrochloride Tablets 40 mg",
"description": "Lurasidone Hydrochloride Tablets 40 mg are an atypical antipsychotic medication primarily prescribed for the treatment of schizophrenia and bipolar disorder, including depressive episodes associated with bipolar I disorder. Manufactured to deliver precise dosing, these tablets help manage symptoms such as hallucinations, delusions, mood swings, and depression by modulating the activity of certain neurotransmitters in the brain. Lurasidone works by balancing dopamine and serotonin receptors, which are often dysregulated in psychiatric conditions, thereby improving thought processes, mood stability, and overall mental function.\nKey Benefits of Lurasidone Hydrochloride Tablets 40 mg\nEffective control of schizophrenia symptoms such as delusions, hallucinations, and disorganized thinking.\nTreatment of major depressive episodes in bipolar I disorder either as monotherapy or adjunctive therapy with lithium or valproate.\nImprovement in mood stabilization helps reduce manic and depressive episodes in bipolar patients.\nGenerally improved patient quality of life by reducing the severity of psychotic and mood symptoms.\nSuitable for adult patients as well as adolescents aged 13 years and older for schizophrenia and patients 10 years and older for bipolar depression under medical guidance.\nFlexible dosing options allow for titration based on clinical response and tolerability.\nSide Effects of Lurasidone Hydrochloride Tablets 40 mg\nLike many antipsychotic medications, Lurasidone may cause side effects, some of which are mild and manageable, while others may require medical attention. Common side effects include nausea, dizziness, restlessness, sedation, weight gain, and gastrointestinal issues such as vomiting or constipation. Some patients may experience extrapyramidal symptoms, which affect muscle control and movement, such as tremors or rigidity. Blood sugar and lipid levels may rise, so periodic monitoring is advised.\nSerious side effects, though less common, can include neuroleptic malignant syndrome (a rare but severe neurological disorder), tardive dyskinesia (involuntary muscle movements), and metabolic changes like significant weight gain, hyperglycemia, or elevated cholesterol. Allergic reactions are rare but possible and require immediate medical attention.\n\nConclusion\n\nLurasidone Hydrochloride Tablets 40 mg offer significant benefits for patients struggling with schizophrenia and bipolar depression by addressing psychotic symptoms and mood disturbances through targeted neurotransmitter modulation. Its efficacy in improving mental health and quality of life is well-documented, but careful adherence to prescribed dosages and medical supervision are essential due to potential side effects. Regular monitoring and open communication with healthcare providers help ensure that patients receive the maximum therapeutic benefit while minimizing risks. This medication should always be used under the guidance of a qualified healthcare professional.",
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