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{ "products": [ { "_id": "68d51d9a26579f4bc195771a", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Glimepiride IP1 mg, Voglibose IP 0.2 MG & Metformin Hydrochloride IP 500 mg ", "description": "GLIMITERIS MV1 0.2 is an advanced fixed-dose combination (FDC) medication designed for adults with Type 2 Diabetes Mellitus (T2DM) who require more than lifestyle modifications or single/dual therapy to maintain optimal blood sugar levels. This innovative formulation brings together the power of three well-established antidiabetic agents—Glimepiride (1 mg), Voglibose (0.2 mg), and Metformin Hydrochloride SR (500 mg)—to provide comprehensive glycemic control.\n\nIt is particularly effective for patients struggling with postprandial hyperglycemia, fasting glucose regulation, and HbA1c reduction, making it a preferred choice in cases of poorly controlled diabetes.\n\n \n\nMechanism of Action\nThe therapeutic benefit of GLIMITERIS MV1 0.2 comes from the unique synergy of its three components, each targeting different aspects of glucose metabolism:\n\n1. Glimepiride (1 mg) – Sulfonylurea\nStimulates insulin secretion by activating pancreatic beta cells.\n\nProvides a long-lasting effect with comparatively lower hypoglycemia risk than older sulfonylureas.\n\nHelps reduce both fasting and postprandial glucose levels.\n\n2. Voglibose (0.2 mg) – Alpha-Glucosidase Inhibitor\nDelays the breakdown and absorption of carbohydrates in the intestine.\n\nMinimizes post-meal glucose spikes (PPBG).\n\nActs locally in the gut and has minimal systemic absorption, which reduces systemic side effects.\n\n3. Metformin Hydrochloride SR (500 mg) – Biguanide\nDecreases hepatic glucose production (gluconeogenesis).\n\nImproves peripheral insulin sensitivity, enhancing glucose uptake in muscles.\n\nDoes not cause hypoglycemia on its own.\n\nThe sustained-release (SR) formulation ensures extended control and reduces gastrointestinal side effects.\n\n \n\nIndications\nGLIMITERIS MV1 0.2 is indicated for:\n\nAdults with Type 2 Diabetes Mellitus.\n\nPatients inadequately controlled with monotherapy or dual therapy.\n\nManagement of fasting and postprandial hyperglycemia.\n\nLong-term HbA1c reduction as part of a comprehensive diabetes care plan.\n\n \n\nKey Benefits\n✅ Comprehensive Blood Sugar Control – Acts on fasting, post-meal, and long-term HbA1c levels.\n✅ Postprandial Spike Management – Voglibose effectively controls carbohydrate-induced sugar surges.\n✅ Reduced Pill Burden – Combines three medicines into a single tablet.\n✅ Lower Hypoglycemia Risk – Metformin and Voglibose balance out Glimepiride’s insulin-secreting effect.\n✅ Weight Management Support – Metformin may promote modest weight loss or prevent weight gain.\n✅ Improved Tolerability – SR formulation of Metformin enhances gastrointestinal comfort.\n\n \n\nDosage and Administration\nRecommended dose: One tablet once or twice daily with meals, or as directed by the physician.\n\nAdministration tips:\n\nTake with the first bite of a main meal to maximize Voglibose’s effect.\n\nSwallow whole with water; do not crush or chew the SR tablet.\n\nDose adjustments: Based on blood sugar monitoring, clinical response, and renal/hepatic function.\n\n \n\nContraindications\nGLIMITERIS MV1 0.2 is not suitable for patients with:\n\nType 1 diabetes or diabetic ketoacidosis.\n\nSevere renal impairment (eGFR <30 mL/min/1.73 m²).\n\nHepatic dysfunction.\n\nSevere gastrointestinal diseases.\n\nHistory of lactic acidosis.\n\nHypersensitivity to Glimepiride, Voglibose, or Metformin.\n\nPregnancy and lactation (unless strictly advised by a physician).\n\n \n\nWarnings and Precautions\nHypoglycemia: Risk is higher when combined with other antidiabetics or with missed meals.\n\nLactic Acidosis: A rare but life-threatening effect of Metformin—renal function monitoring is essential.\n\nGI Side Effects: Voglibose and Metformin may cause bloating, flatulence, or diarrhea (usually temporary).\n\nVitamin B12 Monitoring: Long-term Metformin use may reduce B12 absorption.\n\nLiver and Kidney Function: Regular monitoring is recommended for safe long-term use.\n\n \n\nAdverse Effects\nCommon:\nGlimepiride: Mild hypoglycemia, dizziness, slight weight gain.\n\nVoglibose: Gas, abdominal discomfort, mild diarrhea.\n\nMetformin SR: Nausea, bloating, metallic taste, loose stools.\n\nRare but Serious:\nLactic acidosis (from Metformin).\n\nSevere hypoglycemia (especially if meals are skipped).\n\nAllergic reactions such as rash, itching, or swelling.\n\nElevated liver enzymes.\n\nSeek medical attention if symptoms such as rapid breathing, confusion, severe fatigue, or muscle pain occur.\n\n \n\nDrug Interactions\nIncreased hypoglycemia risk: With insulin, beta-blockers, and sulfonylureas.\n\nReduced Metformin efficacy: With corticosteroids, estrogens, and diuretics.\n\nLactic acidosis risk: Higher with alcohol or iodinated contrast agents. ", "price": 263.0, "discountamount": 80.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2182, "imageuri": "https://productimages.withfloats.com/actual/68d51d9cdf1a4ca2c252370a.png", "tileimageuri": "https://productimages.withfloats.com/tile/68d51d9cdf1a4ca2c252370a.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-09-25T10:46:50.098Z", "updatedon": "2025-09-25T10:46:50.098Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/glimepiride-ip1-mg-voglibose-ip-0-2-mg-metformin-hydrochloride-ip-500-mg-/2182", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "GLIMITERIS MV1 0.2", "category": "", "tags": [], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "6895d48c5f37e7c86e301eb8", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "LAXAVATAR LB DS", "description": "LAXAVATAR LB DS is a specialized probiotic supplement formulated to support and enhance digestive health. Its main active ingredient is Lactic Acid Bacillus, which is present at a concentration of 120 million spores per tablet. This powerful probiotic is designed to promote a healthy balance of gut flora, improving digestive function and overall gastrointestinal well-being. Maintaining a balanced gut microbiota with LAXAVATAR LB DS can help improve nutrient absorption, support regular bowel movements, and potentially strengthen immune function by fostering a healthier digestive system.\n\nWhat is LAXAVATAR LB DS?\n\nLAXAVATAR LB DS is a probiotic tablet containing Lactic Acid Bacillus, a beneficial bacteria that plays a crucial role in maintaining gut health. Probiotics like Lactic Acid Bacillus help replenish and maintain the natural flora in the intestines, which can be disturbed by illness, antibiotics, or poor diet. As a result, this supplement aims to optimize digestive processes, reduce digestive discomfort, and improve bowel regularity.\n\nLactic Acid Bacillus belongs to the class of 'probiotics' and is primarily used to treat diarrhea. Additionally, Lactic Acid Bacillus effectively manages conditions such as irritable bowel syndrome, lactose intolerance, Crohn's disease (an inflammatory bowel disease), and bacterial overgrowth in the intestines, making it a versatile aid for various digestive disorders.\n\nUses of LAXAVATAR LB DS\n\nSupports and restores a healthy balance of gut bacteria.\n\nTreats and prevents different types of diarrhea.\n\nHelps alleviate symptoms of irritable bowel syndrome (IBS).\n\nAssists in managing lactose intolerance by improving digestion of lactose.\n\nAids in reducing bacterial overgrowth in the intestines.\n\nProvides relief from digestive discomfort such as bloating, gas, and indigestion.\n\nSupports regular and healthy bowel movements.\n\nEnhances nutrient absorption and overall digestive efficiency.\n\nMay contribute to boosting the immune response by balancing gut flora.\n\nSide Effects of LAXAVATAR LB DS\n\nGenerally, LAXAVATAR LB DS is well-tolerated with minimal side effects. However, some users may experience mild digestive symptoms, particularly when starting the supplementation. These include:\n\nMild bloating\n\nGas or flatulence\n\nSlight abdominal discomfort\n\nIf these side effects persist, worsen, or if any severe reactions occur, it is advisable to seek medical advice.\n\nPrecautions Before Using LAXAVATAR LB DS\n\nConsult your healthcare provider before use if you have a compromised immune system or serious underlying health conditions.\n\nInform your doctor if you are pregnant or breastfeeding.\n\nThis supplement should not replace conventional treatment for serious gastrointestinal diseases unless advised by a healthcare professional.\n\nDo not use if you have an allergy to probiotics or any ingredients in the tablet.\n\nStore the tablets in a cool, dry place away from direct sunlight and out of reach of children.\n\nDrug Interactions: What Drugs Interact with LAXAVATAR LB DS?\n\nLAXAVATAR LB DS, being a probiotic, generally has a low risk of drug interactions. However, it is important to consider:\n\nAntibiotics: Taking antibiotics alongside probiotics may reduce the effectiveness of the probiotic unless taken at different times of the day. It is usually recommended to space probiotic intake a few hours apart from antibiotics.\n\nImmunosuppressant Drugs: People on immunosuppressive therapy should consult a healthcare provider before taking probiotics like LAXAVATAR LB DS to avoid potential complications.\n\nOther medications: Always inform your healthcare provider of all medications and supplements you are currently taking to rule out any unforeseen interactions.\n\nBy maintaining a healthy gut environment and reducing harmful bacteria, LAXAVATAR LB DS may complement therapies aimed at improving digestive health but always under medical supervision.\n\nLAXAVATAR LB DS with its Lactic Acid Bacillus ingredient provides a reliable, scientifically backed solution for supporting digestive health and managing several gastrointestinal conditions. With proper usage and precautions, it can be a valuable addition to maintaining a balanced and well-functioning digestive system.", "price": 85.0, "discountamount": 26.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2159, "imageuri": "https://productimages.withfloats.com/actual/6895d4907303edb057e2a39c.png", "tileimageuri": "https://productimages.withfloats.com/tile/6895d4907303edb057e2a39c.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-08-08T10:42:20.432Z", "updatedon": "2025-08-08T10:42:20.432Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/laxavatar-lb-ds/2159", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "lactic acid bacillus tablet", "category": "GENERAL RANGE", "tags": [ "lactic acid bacillus tablet" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "68949d4ea0059029dc8c8915", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "BENZTETRA 25", "description": "BENZTETRA 25 contains the active ingredient tetrabenazine 25mg, a specialized medication used primarily to manage involuntary movements associated with neurological disorders. Tetrabenazine is classified as a vesicular monoamine transporter 2 (VMAT2) inhibitor and works by regulating the levels of neurotransmitters such as dopamine, serotonin, norepinephrine, and histamine in the brain. This correction of chemical imbalances helps reduce excessive and uncontrolled muscle movements. BENZTETRA 25 is especially valuable for patients suffering from movement disorders that significantly impact their daily functioning. It helps improve motor control, thereby enhancing quality of life for those affected. This medication is prescribed mainly to treat chorea—a movement disorder characterized by jerky, irregular, and uncontrollable muscle movements—that is caused by Huntington disease.\n\nWhat is BENZTETRA 25?\nBENZTETRA 25 is a therapeutic tablet containing tetrabenazine 25mg, designed to treat involuntary movements (chorea) linked to Huntington disease. It does not cure Huntington disease nor address cognitive or psychiatric symptoms of the disease but effectively reduces the severity of abnormal movements by altering neurotransmitter activity in the brain.\n\nUses of BENZTETRA 25\n\nTo treat chorea (a movement disorder) that is caused by Huntington disease.\n\nTo control involuntary muscle movements in Huntington’s disease patients.\n\nManagement of other hyperkinetic movement disorders as determined by a healthcare provider (such as tardive dyskinesia or Tourette syndrome in some cases).\n\nTo reduce excessive motor activity caused by abnormal nerve signaling in the brain, improving voluntary muscle control.\n\nSide Effects of BENZTETRA 25\n\nDrowsiness and fatigue, which may affect alertness.\n\nInsomnia or difficulty sleeping.\n\nNausea, vomiting, or abdominal discomfort.\n\nParkinsonism symptoms such as tremors, muscle rigidity, and slowed movements (bradykinesia).\n\nMood alterations including depression, anxiety, and in severe cases, suicidal thoughts.\n\nRare serious reactions like allergic responses, heart rhythm irregularities, or neuroleptic malignant syndrome (characterized by high fever, muscle stiffness).\n\nPrecautions Before Using BENZTETRA 25\n\nInform your doctor if you have a history of depression, suicidal thoughts, or any psychiatric illness.\n\nAvoid use if you have severe liver disease or have recently taken monoamine oxidase inhibitors (MAOIs).\n\nCaution in patients with cardiac issues due to potential QT interval prolongation.\n\nUse with care when driving or operating machinery as BENZTETRA 25 may cause dizziness or drowsiness.\n\nDo not stop the medication suddenly without consulting your healthcare provider, as symptoms might worsen.\n\nRegular monitoring by a healthcare professional is recommended to assess side effects and efficacy.\n\nDrug Interactions: What Drugs Interact with BENZTETRA 25?\n\nMAO inhibitors such as isocarboxazid, phenelzine, selegiline, and others can cause dangerous interactions and should not be used concurrently.\n\nOther drugs that affect serotonin levels, including selective serotonin reuptake inhibitors (SSRIs), may increase the risk of serotonin syndrome.\n\nCaution with other medications known to prolong the QT interval or those affecting dopamine systems.\n\nInteractions with neuroleptics or antipsychotics require close medical supervision due to additive effects on movement and mood.\n\nConclusion\nBENZTETRA 25, containing tetrabenazine 25mg, is a vital medication for managing chorea associated with Huntington disease by modulating neurotransmitter levels in the brain to reduce involuntary movements. While it offers substantial benefits in improving motor control, careful attention to side effects, precautions, and drug interactions is essential for safe and effective use. Always follow the guidance of a healthcare professional when using BENZTETRA 25 to ensure optimal outcomes and safety.", "price": 425.0, "discountamount": 128.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2158, "imageuri": "https://productimages.withfloats.com/actual/68949d54c82f93461bdc841f.png", "tileimageuri": "https://productimages.withfloats.com/tile/68949d54c82f93461bdc841f.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-08-07T12:34:22.411Z", "updatedon": "2025-08-07T12:34:22.411Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/benztetra-25/2158", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "tetrabenazine 25mg", "category": "NEUROLOGY RANGE", "tags": [ "tetrabenazine 25mg" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "68832b7f217a4e897b4812dd", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "SMITHCON ACID TABLETS", "description": "SMITHCON ACID TABLETS is a scientifically formulated oral medication designed to offer comprehensive relief from gastrointestinal disturbances such as acidity, gas, bloating, indigestion, and abdominal cramps. This tablet combines three powerful ingredients: Dicyclomine Hydrochloride 10 mg, Simethicone 20 mg, and Ranitidine Hydrochloride 150 mg. Together, these compounds address various symptoms of digestive distress and provide fast, effective, and lasting comfort.\n\nWhat is SMITHCON ACID TABLETS?\nSMITHCON ACID TABLETS is a combination medication containing three active ingredients:\n\nDicyclomine Hydrochloride 10 mg – An antispasmodic agent that works by relaxing the smooth muscles of the stomach and intestines, helping relieve painful cramps, spasms, and abdominal discomfort.\n\nSimethicone 20 mg – An anti-foaming agent that breaks down gas bubbles in the stomach and intestines, providing quick relief from bloating, fullness, and abdominal pressure.\n\nRanitidine Hydrochloride 150 mg – A histamine-2 (H2) receptor blocker that reduces the production of stomach acid, effectively treating heartburn, acid reflux, and indigestion.\n\nUses of SMITHCON ACID TABLETS:\nSMITHCON ACID TABLETS is used to treat a variety of gastrointestinal conditions, including:\n\nAcid indigestion and heartburn\n\nGastroesophageal reflux disease (GERD)\n\nFlatulence and bloating\n\nAbdominal cramps and spasms\n\nIrritable bowel syndrome (IBS)\n\nFunctional dyspepsia\n\nExcessive stomach acid production\n\nThe triple-action mechanism provides targeted relief from gas, acidity, and muscle spasms, making SMITHCON ACID TABLETS an ideal choice for patients experiencing multiple digestive complaints.\n\nSide Effects of SMITHCON ACID TABLETS:\nWhile generally well-tolerated, some patients may experience side effects such as:\n\nDry mouth\n\nDizziness or light-headedness\n\nNausea or constipation\n\nBlurred vision\n\nDrowsiness\n\nAllergic reactions (rare)\n\nHeadache or mild abdominal discomfort\n\nIf any of these symptoms persist or worsen, it is advised to consult a healthcare professional.\n\nPrecautions Before Using SMITHCON ACID TABLETS:\nBefore starting SMITHCON ACID TABLETS, inform your doctor if you have:\n\nGlaucoma\n\nEnlarged prostate\n\nObstructive gastrointestinal conditions\n\nLiver or kidney disease\n\nHeart conditions\n\nPregnancy or breastfeeding\n\nAvoid alcohol and activities requiring mental alertness if you experience drowsiness or dizziness while taking this medication.\n\nDrug Interactions: What Drugs Interact With SMITHCON ACID TABLETS?\nThe following medications may interact with SMITHCON ACID TABLETS:\n\nAnticholinergic drugs (may enhance side effects of dicyclomine)\n\nAntacids or sucralfate (may interfere with ranitidine absorption)\n\nKetoconazole, itraconazole (reduced absorption due to ranitidine)\n\nCNS depressants like alcohol, sedatives (increased risk of drowsiness)\n\nDigoxin or blood thinners (may be affected by changes in stomach acid levels)\n\nAlways inform your healthcare provider about all medications and supplements you are taking to avoid potential interactions.\n\nParaphrased Clinical Note:\nRanitidine, dicyclomine hydrochloride, and simethicone tablets are a combination medication used to treat various gastrointestinal issues. Ranitidine is an H2 blocker that reduces stomach acid production, helping with heartburn and indigestion. Dicyclomine is an antispasmodic that relaxes stomach and intestinal muscles, relieving cramps and pain. Simethicone helps to relieve gas and bloating by breaking down gas bubbles.\n\nConclusion:\nSMITHCON ACID TABLETS offers a dependable solution for those suffering from common gastrointestinal complaints such as acidity, gas, and abdominal pain. With its triple-action blend of dicyclomine hydrochloride 10mg, simethicone 20 mg, and ranitidine hydrochloride 150 mg, it provides swift and targeted relief for a better quality of life. Consult your physician before use and follow dosage guidelines to maximize its benefits.", "price": 70.0, "discountamount": 21.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2152, "imageuri": "https://productimages.withfloats.com/actual/68832b83093884639e4d0879.png", "tileimageuri": "https://productimages.withfloats.com/tile/68832b83093884639e4d0879.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-07-25T07:00:15.779Z", "updatedon": "2025-07-25T07:00:15.779Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/smithcon-acid-tablets/2152", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "ranitidine dicyclomine hydrochloride and simethicone tablets", "category": "GASTROLOGYRANGE", "tags": [ "dicyclomine hydrochloride and simethicone tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "687b663ab566f87e592f9a0f", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "PYLODIGEST ENZYME", "description": "PYLODIGEST ENZYME is a comprehensive digestive aid specially formulated with a powerful blend of Fungal Diastase, Papain, and Activated Charcoal. These natural and enzymatic components work synergistically to enhance the digestive process, alleviate common gastrointestinal disturbances, and promote better nutrient absorption. Whether you're dealing with a heavy meal, bloating, or general digestive discomfort, PYLODIGEST ENZYME offers effective relief and supports your gut health.\n\nWhat is PYLODIGEST ENZYME?\nPYLODIGEST ENZYME is a multi-action digestive supplement that contains:\n\nFungal Diastase: A digestive enzyme that breaks down complex carbohydrates into simpler sugars for easier digestion.\n\nPapain: A proteolytic enzyme derived from papaya, which helps in breaking down proteins into amino acids.\n\nActivated Charcoal: A natural absorbent that binds to gas, toxins, and impurities in the gut, helping relieve bloating and flatulence.\n\nFungal Diastase + Papain + Activated Charcoal helps relieve digestive disorders like indigestion, heartburn, gas, and abdominal discomfort.\n\nUses of PYLODIGEST ENZYME:\nThis combination is widely used to manage a range of digestive problems, including:\n\nIndigestion and dyspepsia\n\nBloating and excessive gas\n\nAcidity and heartburn\n\nAbdominal discomfort after meals\n\nFlatulence\n\nPoor digestion due to enzyme deficiency\n\nBy breaking down proteins, carbohydrates, and absorbing excess gas, PYLODIGEST ENZYME helps restore healthy digestion and improves overall gastrointestinal comfort.\n\nSide Effects of PYLODIGEST ENZYME:\nWhile PYLODIGEST ENZYME is generally well-tolerated, some individuals may experience:\n\nMild gastrointestinal disturbances such as nausea or diarrhea\n\nAllergic reactions like rash or itching (rare)\n\nConstipation or black stools (due to activated charcoal)\nIf any side effects persist or worsen, it is advisable to consult a healthcare provider immediately.\n\nPrecautions Before Using PYLODIGEST ENZYME:\n\nConsult a doctor before using if you are pregnant or breastfeeding\n\nUse with caution in patients with known allergies to any of the ingredients\n\nAvoid excessive or prolonged use without medical supervision\n\nNot recommended for use in children without pediatric guidance\n\nMaintain adequate hydration during use, especially when taking activated charcoal\n\nDrug Interactions – What Drugs Interact With PYLODIGEST ENZYME?\nActivated charcoal may reduce the effectiveness of certain oral medications by binding to them in the stomach. These include:\n\nAntibiotics (e.g., tetracycline, ciprofloxacin)\n\nAntiepileptic drugs\n\nBirth control pills\n\nCardiac medications like digoxin\nTo prevent interaction, it's advisable to take PYLODIGEST ENZYME at least 2 hours before or after other medications. Always inform your doctor or pharmacist about all the medications and supplements you are taking.\n\nConclusion:\nPYLODIGEST ENZYME is a reliable and effective digestive formula that provides natural enzymatic support to manage everyday digestive troubles. Its triple-action blend of Fungal Diastase, Papain, and Activated Charcoal makes it a trusted choice for those seeking relief from indigestion, gas, and bloating. Ideal for post-meal comfort, this product reflects Steris Healthcare’s commitment to quality, patient safety, and affordable care.", "price": 60.0, "discountamount": 20.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": null, "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2147, "imageuri": "https://productimages.withfloats.com/actual/687b66462c3676c2dacf8aa9.png", "tileimageuri": "https://productimages.withfloats.com/tile/687b66462c3676c2dacf8aa9.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-07-19T09:32:42.984Z", "updatedon": "2025-07-19T09:32:42.984Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/pylodigest-enzyme/2147", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "fungal diastase papain and activated charcoal tablets", "category": "GASTROLOGYRANGE", "tags": [ "Fungal diastase Papain and activated charcoal tablets Uses in Hindi", "fungal diastase papain and activated charcoal tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "685d3aee734cdee72771a953", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "RIFAXEMANIA 200", "description": "RIFAXEMANIA 200 is a targeted intestinal antibiotic that contains Rifaximin 200 mg. This medication is widely used to treat gastrointestinal infections without affecting the rest of the body. Because of its poor absorption into the bloodstream, it works directly in the digestive tract, helping to treat infections like traveler’s diarrhea, IBS-D (Irritable Bowel Syndrome with Diarrhea), and complications related to liver conditions such as hepatic encephalopathy. RIFAXEMANIA 200 is formulated in tablet form, offering convenience, precision, and effective relief.\n\nWhat is Rifaximin 200 mg?\nRifaximin 200 mg is a non-systemic, semi-synthetic antibiotic derived from the rifamycin group. It functions by binding to bacterial RNA polymerase, preventing bacteria from multiplying. Since it stays confined to the gastrointestinal tract and is not absorbed significantly into the bloodstream, it’s ideal for treating localized gut infections.\n\nThis unique property makes the rifaximin 200 tablet suitable for conditions that do not require full-body antibiotic exposure, ensuring effective treatment with minimal side effects.\n\nUses of Rifaximin 200 Tablet\nRifaximin 200 mg is prescribed in tablet form to treat a variety of gut-related conditions. Common uses include the treatment of traveler’s diarrhea caused by non-invasive strains of E. coli, reducing the recurrence of hepatic encephalopathy in individuals with chronic liver disease, and relieving symptoms associated with IBS-D such as diarrhea, bloating, and abdominal pain.\n\nAdditionally, rifaximin is sometimes used to manage small intestinal bacterial overgrowth (SIBO), functional digestive disorders, and as part of combination therapy in certain inflammatory bowel conditions. These rifaximin 200 mg uses make it a valuable option for both acute and chronic digestive health management.\n\nSide Effects of Rifaximin 200 mg\nRifaximin is generally considered safe and well-tolerated due to its low systemic absorption. However, like all medications, some individuals may experience side effects. These can include nausea, abdominal pain, bloating, headache, constipation, or mild diarrhea. In rare cases, allergic skin reactions or fatigue may occur.\n\nMost of these effects are mild and temporary. If symptoms persist or worsen, it is advisable to contact a healthcare professional for further evaluation.\n\nPrecautions Before Using RIFAXEMANIA 200\nBefore using RIFAXEMANIA 200, patients should consider a few important precautions. Anyone with a known allergy to rifaximin or related antibiotics in the rifamycin class should avoid this medication. It should also be used cautiously in people with moderate to severe liver disease, as systemic absorption may be higher in such cases.\n\nPregnant or breastfeeding individuals should only use this product after consulting a physician. Rifaximin 200 mg is not recommended in cases of bloody diarrhea or fever, where a more systemic antibiotic may be required. Proper diagnosis and physician supervision are essential before starting treatment.\n\nDrug Interactions with Rifaximin 200 mg\nAlthough rifaximin is minimally absorbed into the bloodstream, it may still interact with certain medications, particularly in patients with liver impairment. For example, cyclosporine can significantly raise blood levels of rifaximin, requiring dose adjustments.\n\nOther drugs that may interact include warfarin (where INR monitoring is necessary), oral contraceptives (as effectiveness may decrease), and antiepileptic medications (which may have altered therapeutic effects). Always inform your doctor about all current medications, including over-the-counter supplements and herbal products, before starting rifaximin 200 tablet.\n\nWhy RIFAXEMANIA 200 is Recommended\nRIFAXEMANIA 200 offers precise and localized antibacterial action in the intestines without exposing the rest of the body to unnecessary drug effects. This makes it a preferred option for managing conditions like traveler’s diarrhea, hepatic encephalopathy, and IBS-D. Its convenient tablet form, reliable safety profile, and effectiveness in reducing symptoms make it a valuable part of modern gastrointestinal therapy.\n\nConclusion\nRIFAXEMANIA 200, containing Rifaximin 200 mg, is a clinically effective and safe treatment for bacterial infections limited to the gastrointestinal tract. With minimal absorption and a strong local antibacterial effect, it helps address common and chronic digestive conditions while minimizing adverse effects. Whether you are managing liver-related complications or looking for relief from persistent diarrhea and gut discomfort, RIFAXEMANIA 200 delivers dependable results.\n\nAlways follow your healthcare provider’s instructions for dosage and duration to ensure the best possible outcomes.\n\n", "price": 259.0, "discountamount": 78.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "rifaxemania 200", "rifaxemania 200 patients", "breastfeeding individuals", "valuable part", "current medications", "antiepileptic medications", "cases pregnant", "mild diarrhea", "effective relief", "rifaxemania 200rifaxemania 200", "rifaximin 200 mg", "persistent diarrhea", "safe treatment", "clinically effective", "preferred option", "herbal products", "overthecounter supplements", "oral contraceptives", "inr monitoring", "minimally absorbed", "physician supervision", "bloody diarrhea", "rifamycin class", "related antibiotics", "important precautions", "evaluation precautions", "welltolerated due", "valuable option", "combination therapy", "diarrhea bloating", "hepatic encephalopathy", "noninvasive strains", "tablet form", "absorbed significantly", "stays confined", "rifamycin group", "works directly", "poor absorption", "symptoms persist", "relieving symptoms", "liver impairment", "healthcare professional", "coli reducing", "complications related", "systemic absorption", "treat infections", "gastrointestinal tract", "minimal absorption", "managing conditions", "systemic antibiotic", "liver conditions", "reducing symptoms make", "treat gastrointestinal infections", "low systemic absorption", "managing liverrelated complications", "travelers diarrhea caused", "unique property makes", "minimal side effects", "chronic digestive conditions", "inflammatory bowel conditions", "gutrelated conditions common", "digestive tract helping", "healthcare providers instructions", "severe liver disease", "generally considered safe", "chronic liver disease", "targeted intestinal antibiotic", "minimizing adverse effects", "bacterial infections limited", "unnecessary drug effects", "altered therapeutic effects", "experience side effects", "helps address common", "localized antibacterial action", "required proper diagnosis" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2138, "imageuri": "https://productimages.withfloats.com/actual/685d3af25609b7ccc73e989b.png", "tileimageuri": "https://productimages.withfloats.com/tile/685d3af25609b7ccc73e989b.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-06-26T12:19:58.961Z", "updatedon": "2025-06-26T12:20:59.942Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/rifaxemania-200/2138", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "rifaximin 200", "category": "GASTROLOGYRANGE", "tags": [ "rifaximin 200", "rifaximin 200 mg uses in hindi", "rifaximin 200 mg uses" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "685bf1b58f1119e73c154485", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "REBAMPEE OTIC", "description": "REBAMPEE OTIC is an advanced nutraceutical formulation combining rebamipide, alpha lipoic acid, and acetylcysteine, uniquely designed to support inner ear health and manage age-related hearing loss. The synergistic combination of these three active ingredients works to reduce oxidative stress, prevent cellular degeneration, and support nerve function, offering a targeted solution in cases where oxidative damage contributes to auditory decline. The formulation, known as rebamipide alpha 100mg lipoic acid 100mg and acetylcysteine 100mg capsules, is gaining attention in otolaryngology as a supportive therapy for managing sensorineural and degenerative hearing conditions.\n\nWhat is REBAMPEE OTIC?\nREBAMPEE OTIC is a capsule formulation composed of three clinically significant ingredients:\n\nRebamipide (100 mg): Known for its mucosal protective and antioxidant properties, it plays a role in reducing inflammation and protecting the delicate inner ear structures from oxidative damage.\n\nAlpha Lipoic Acid (100 mg): A powerful antioxidant that supports nerve regeneration and protects against cellular degeneration in the cochlea and auditory pathways.\n\nAcetylcysteine (100 mg): An effective mucolytic and precursor to glutathione, it combats oxidative stress and may help reduce cochlear damage due to noise, drugs, or aging.\n\nTogether, they act to protect and rejuvenate auditory cells, making REBAMPEE OTIC a promising aid in the treatment and management of age-related hearing loss and oxidative stress-induced otological damage.\n\nUses of REBAMPEE OTIC\nUsed in the treatment of age-related hearing loss (presbycusis)\n\nHelps protect auditory nerve cells from oxidative damage\n\nSupports cochlear and inner ear health in degenerative auditory conditions\n\nMay aid in managing hearing impairment due to noise exposure or ototoxic medications\n\nPromotes antioxidant activity and inner ear cellular regeneration\n\nPossible Side Effects\nMost people tolerate REBAMPEE OTIC well, but some may experience mild to moderate side effects such as:\n\nNausea\n\nMild headache\n\nHeartburn\n\nDizziness\n\nAbdominal discomfort\n\nFatigue\n\nSerious Side Effects (Rare)\nIn rare cases, more severe effects may occur:\n\nAllergic reactions such as skin rash, itching, or swelling\n\nSevere abdominal pain\n\nBreathing difficulty or tightness in the chest\n\nSevere dizziness or fainting\n\nHepatic enzyme elevation or liver dysfunction\n\nSeek immediate medical attention if any serious symptoms occur.\n\nPrecautions Before Using REBAMPEE OTIC\nConsult your physician before starting if you have liver disease, kidney dysfunction, or any autoimmune condition\n\nNot recommended during pregnancy or breastfeeding unless prescribed by a doctor\n\nUse with caution in individuals with a known allergy to any of the ingredients\n\nAvoid excessive alcohol consumption during the course as it may increase liver stress\n\nNot to be used as a replacement for medically prescribed treatments for hearing loss without a physician’s recommendation\n\nDrug Interactions\nREBAMPEE OTIC may interact with several medications. It is important to inform your healthcare provider about all drugs you are currently taking, including supplements and herbal products.\n\nWhat drugs interact with REBAMPEE OTIC?\n\nAnticoagulants (e.g., warfarin): Alpha lipoic acid may enhance the anticoagulant effect, increasing the risk of bleeding\n\nAntidiabetic medications: May enhance the glucose-lowering effect, increasing the risk of hypoglycemia\n\nIron supplements: Acetylcysteine may interact with iron metabolism\n\nCertain antibiotics: NAC (acetylcysteine) may reduce the efficacy of some antibiotics if taken simultaneously\n\nThyroid medications: Alpha lipoic acid may interfere with thyroid hormone levels\n\nCisplatin and aminoglycoside antibiotics: When used with antioxidants like NAC, ototoxicity might be reduced, but consult your doctor for adjusted therapy\n\nAlways consult your doctor or pharmacist before combining REBAMPEE OTIC with other medications.\n\nConclusion\nREBAMPEE OTIC is a scientifically developed capsule combining rebamipide, alpha lipoic acid, and acetylcysteine, each known for its distinct cellular protective roles. When used as directed, this formula helps mitigate the effects of age-related hearing loss and supports inner ear health through potent antioxidant action. Safe, effective, and based on evidence-backed ingredients, REBAMPEE OTIC offers new hope for those experiencing the early signs of auditory decline.", "price": 280.0, "discountamount": 84.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "reduce absorption", "rebamipide 100mg", "gastrointestinal issues", "vasodilators caution", "drugs interact", "worsens consult", "liver enzymes", "promote healing", "chronic conditions", "chronic inflammation", "individuals suffering", "lasting relief", "acetylcysteine 100mgtargeting", "wellbalanced combination", "activated charcoal", "respiratory sensitivity", "breastfeeding womenonly", "kidney disorders", "precautions inform", "symptom persists", "side effects", "rare cases", "taste due", "diarrhea headache", "generally welltolerated", "burning sensation", "tingling numbness", "metabolic disorders", "oxidative stress", "ulcers reduction", "gastric mucosa", "diabetic neuropathy", "neurological protection", "oxidative damage", "powerful mucolytic", "universal antioxidant", "multifunctional capsule", "ideal adjunct", "tripleaction formulation", "neuroprotective properties", "antioxidant mucosalprotective", "cellular health", "mucosal protection", "nerve health", "healthcare provider", "medications antacids", "antioxidant agent", "rebampee otic", "starting rebampee otic", "rebampee oticrebampee otic", "medical supervision patients", "healthcare professional precautions", "acetylcysteine temporary increase", "mucosal protective agent", "medications herbal supplements", "cellular defense making", "supports nerve regeneration", "doctors dosage instructions", "optimal results follow", "simultaneously iron supplements", "dizziness skin rash", "ingredients work synergistically" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2137, "imageuri": "https://productimages.withfloats.com/actual/685bf1b95d6f047570824865.png", "tileimageuri": "https://productimages.withfloats.com/tile/685bf1b95d6f047570824865.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-06-25T12:55:17.97Z", "updatedon": "2025-07-02T06:35:37.588Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/rebampee-otic/2137", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "rebamipide alpha lipoic acid and acetylcysteine capsules", "category": "GASTROLOGYRANGE", "tags": [ "rebamipide alpha lipoic acid and acetylcysteine capsules", "rebamipide tablets uses in hindi" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "681c5e9e5a26e4010ea42029", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "ST-GLIPTIN M 100/ 1000", "description": "ST-GLIPTIN M 100/1000 is an advanced oral antidiabetic medication designed for the effective management of Type 2 Diabetes Mellitus. This powerful combination of Sitagliptin (100 mg) and Metformin Hydrochloride (1000 mg) offers dual action in controlling elevated blood glucose levels, especially in patients who do not respond adequately to metformin or sitagliptin alone. It is intended for adults and is generally used in conjunction with diet and exercise to enhance glycemic control.\n\nKey Ingredients\nSitagliptin (100 mg)\nSitagliptin is a DPP-4 (Dipeptidyl Peptidase-4) inhibitor that increases the levels of incretin hormones, which help regulate blood sugar by increasing insulin release and decreasing glucagon levels.\n\nMetformin Hydrochloride (1000 mg)\nMetformin belongs to the biguanide class of antidiabetics. It works by reducing the amount of sugar produced by the liver and improves the body’s sensitivity to insulin, facilitating better glucose utilization.\n\nKey Benefits\nHelps reduce both fasting and postprandial (after-meal) blood glucose levels effectively\nImproves overall glycemic control in patients with Type 2 diabetes\nCombines two different mechanisms of action for better diabetes management\nMinimizes the risk of hypoglycemia compared to other antidiabetic therapies\nMay support weight neutrality or slight weight loss in diabetic individuals\n\nHow Does It Work?\nST-GLIPTIN M 100/1000 works through a synergistic mechanism by combining two effective antidiabetic agents:\n\nSitagliptin enhances the levels of incretin hormones, which help the pancreas produce more insulin and reduce the secretion of glucagon, especially when blood sugar is high.\nMetformin reduces hepatic glucose production and increases insulin sensitivity, which helps the body use glucose more efficiently.\nTogether, these agents provide comprehensive blood sugar control by addressing multiple physiological pathways involved in glucose metabolism.\n\nDirections for Use\nTake ST-GLIPTIN M 100/1000 exactly as prescribed by your physician.\nIt is typically taken once or twice daily with meals to reduce gastrointestinal side effects and optimize absorption.\nSwallow the tablet whole with water. Do not crush or chew the tablet.\nMaintain a balanced diet and follow an active lifestyle for best results.\nRegular blood sugar monitoring is essential to assess effectiveness and make any necessary dosage adjustments.\n\nSide Effects\nCommon side effects may include nausea, diarrhea, stomach upset, or headache.\nSome individuals may experience respiratory tract infections, sore throat, or a runny nose.\nLactic acidosis is a rare but serious side effect associated with high-dose metformin—seek immediate medical attention if symptoms like unusual fatigue, muscle pain, difficulty breathing, or abdominal discomfort occur.\nAllergic reactions such as rash, itching, or swelling are uncommon but possible.\nAlways inform your doctor of any persistent or bothersome side effects for timely intervention.", "price": 225.0, "discountamount": 68.0, "currencycode": "INR", "priority": 1000000, "isfreeshipmentavailable": false, "shipmentduration": 1, "_keywords": [ "1001000 works", "100 1000stgliptin", "work stgliptin", "balanced diet", "tablet maintain", "diabetic individuals", "sitagliptin 100 mg", "timely intervention", "rash itching", "medical attention", "highdose metforminseek", "assess effectiveness", "active lifestyle", "pancreas produce", "synergistic mechanism", "antidiabetic therapies", "hypoglycemia compared", "glycemic control", "biguanide class", "incretin hormones", "respond adequately", "powerful combination", "insulin facilitating", "sugar produced", "side effect", "bodys sensitivity", "effective management", "blood sugar", "increases insulin sensitivity", "regulate blood sugar", "glucose metabolism directions", "increasing insulin release", "bothersome side effects", "diabetes management minimizes", "optimize absorption swallow", "slight weight loss", "support weight neutrality" ], "isarchived": false, "isavailable": true, "applicationid": null, "productindex": 2107, "imageuri": "https://productimages.withfloats.com/actual/681c5e9f5e6dd8f19a0309c3.png", "tileimageuri": "https://productimages.withfloats.com/tile/681c5e9f5e6dd8f19a0309c3.png", "images": null, "totalqueries": 0, "gpid": null, "groupproductid": null, "createdon": "2025-05-08T07:34:54.516Z", "updatedon": "2025-05-08T07:35:36.782Z", "buyonlinelink": null, "producturl": "http://WWW.STERISINDIA.COM/products/st-gliptin-m-100-1000/2107", "availableunits": -1.0, "iscodavailable": false, "isprepaidonlineavailable": false, "maxcodorders": 0, "maxprepaidonlineorders": 0, "uniquepaymenturl": null, "brandname": "sitagliptin and metformin hydrochloride tablets", "category": "DIABETIC RANGE", "tags": [ "Sitagliptin and Metformin hydrochloride tablets Uses in Hindi", "sitagliptin and metformin hydrochloride tablets 50/1000 uses in hindi", "sitagliptin and metformin hydrochloride tablets" ], "variants": false, "keyspecification": null, "otherspecifications": null, "pickupaddressreferenceid": null, "paymenttype": "UniquePaymentUrl", "producttype": "products", "hsncode": null, "gstslab": 0.0, "isnotforsale": false }, { "_id": "680cb27bf2104bea7f8374cb", "fptag": "STERISHEALTHCARE", "merchantname": null, "customwidgets": null, "externalsourceid": null, "name": "Multi Enzyme Complex Probiotic Capsules", "description": "PYLODIGEST PRO is a scientifically formulated supplement that combines the power of a Multi Enzyme Complex with the benefits of Probiotic Capsules to promote optimal digestive health. Designed to support a healthy gut environment, it aids in efficient digestion, nutrient absorption, and maintaining the natural balance of good bacteria in the intestines. Ideal for individuals experiencing digestive discomfort, bloating, irregular bowel movements, or those aiming to enhance their overall gastrointestinal wellness.\n\nKey Benefits\nSupports complete digestion of carbohydrates, proteins, fats, and fibers\n\nHelps reduce bloating, gas, and indigestion\n\nRestores and maintains a healthy gut microbiome\n\nBoosts immune function through improved gut health\n\nEnhances nutrient absorption and overall energy levels\n\nAids in managing gut-related issues like constipation, diarrhea, and irritable bowel syndrome (IBS)\n\nPromotes overall gastrointestinal comfort and wellness\n\nHow Does It Work?\nPYLODIGEST PRO works through a synergistic combination of enzymes and probiotics:\n\nThe Multi Enzyme Complex initiates and enhances the breakdown of different food components into simpler, absorbable forms, easing the workload of the digestive system and preventing discomfort after meals.\n\nThe Probiotics recolonize the gut with beneficial bacteria, which help in fermenting undigested food, producing essential vitamins, protecting against harmful bacteria, and modulating immune responses.\nTogether, they ensure smoother digestion, better gut health, and improved systemic wellness.\n\nDirections for Use\nTake one capsule of PYLODIGEST PRO daily, preferably with meals or as directed by your healthcare provider.\n\nSwallow the capsule whole with water; do not chew or crush it.\n\nFor best results, incorporate into your daily routine alongside a balanced diet.\n\nConsult your healthcare provider before use if you are pregnant, nursing, or taking other medications.\n\nSide Effects\nPYLODIGEST PRO is generally safe and well-tolerated. 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