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STERISHEALTHCARE 573431969ec6680ff811d9bc Products https://www.sterisindia.com
Home Products Enzalutamide 160 mg Tablet
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Oncology by ENZULAMIDE 160

Enzalutamide 160 mg Tablet

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ENZULAMIDE 160 Enzalutamide 160mg capsules represent a breakthrough in targeted therapy for advanced prostate cancer, specifically designed to inhibit androgen receptor signaling at multiple levels, slowing cancer progression even in castration-resistant cases. This oral medication, typically taken as a single daily 160mg dose (four 40mg capsules), binds directly to the androgen receptor, preventing nuclear translocation and DNA binding, which starves hormone-dependent prostate tumors of growth signals. Patients with metastatic castration-resistant prostate cancer (mCRPC), non-metastatic CRPC (nmCRPC), or metastatic castration-sensitive prostate cancer (mCSPC) benefit from its ability to delay disease advancement, reduce PSA levels, and extend progression-free survival.​ Administered continuously without cycling, enzalutamide 160mg maintains steady-state plasma levels for consistent anti-tumor activity, making it suitable for long-term management alongside standard care. Its role expands beyond initial hormone therapy failures, offering hope where traditional options falter.​ Product Uses: Targeting Advanced Prostate Cancer Enzalutamide 160mg primarily treats metastatic castration-resistant prostate cancer (mCRPC) post-chemotherapy or in pre-chemo settings, where tumors grow despite low testosterone. It excels in non-metastatic CRPC (nmCRPC) by delaying metastasis onset, with trials showing median metastasis-free survival exceeding 3 years versus placebo. In mCSPC, combination with ADT prolongs overall survival by months, reducing radiographic progression risks.​ Clinicians prescribe it for high-risk patients with rising PSA despite androgen deprivation therapy (ADT), as it shrinks tumors, alleviates bone pain from metastases, and improves quality of life metrics like urinary function and fatigue scores. Regular monitoring via PSA doubling time and imaging guides ongoing use.​ Key Benefits of Enzalutamide 160mg Enzalutamide 160mg delivers transformative outcomes through potent androgen blockade: Extended Progression-Free Survival: PROSPER trial data indicate 97% risk reduction in metastasis or death for nmCRPC; ENZAMET shows 33% overall survival benefit in mCSPC.​ PSA Response Rates: Over 78% achieve ≥50% PSA decline in mCRPC, correlating with radiographic stability and symptom palliation.​ Bone Metastasis Control: Lowers skeletal-related events by 30-40%, preserving mobility and reducing fracture incidence when paired with bone agents.​ Quality of Life Preservation: FACT-P scores improve in pain, appetite, and emotional well-being domains, enabling patients to maintain daily activities longer.​ Oral Convenience: Once-daily dosing without food restrictions enhances adherence compared to infusions or multi-pill regimens.​ These advantages position enzalutamide 160mg as a cornerstone in modern prostate cancer protocols, particularly for fit patients tolerating its profile.​ Side Effects: Managing Risks Effectively While effective, enzalutamide 160mg carries side effects from androgen suppression and receptor antagonism, affecting 70-90% of users to varying degrees. Most prove manageable with supportive care, dose holds, or adjustments, but vigilance remains essential.​ Common Side Effects Frequently reported (≥10%) issues include: Fatigue/Asthenia (30-40%): Profound tiredness impacting daily tasks; rest, exercise, and stimulants like modafinil help.​ Hot Flashes (20-25%): Sudden heat waves; cooling strategies and SSRIs alleviate symptoms.​ Musculoskeletal Pain (15-30%): Joint/muscle aches; NSAIDs or physical therapy provide relief.​ Diarrhea/Constipation (10-20%): Alternating bowel changes; fiber, hydration, and laxatives balance gut function.​ Hypertension (10-15%): Blood pressure elevations; routine monitoring and antihypertensives control spikes.​ These transient effects often peak in first months, diminishing with acclimation.​ Serious Side Effects Seek immediate care for: Seizures (1-2%): Risk higher with brain history; anticonvulsants or discontinuation advised.​ Falls/Fractures (10-15%): Due to weakness, dizziness; fall precautions and bone density scans mitigate.​ Cardiovascular Events: Myocardial infarction, strokes (2-5%); lipid/BP checks essential.​ Posterior Reversible Encephalopathy Syndrome (PRES): Rare confusion, seizures, vision loss; MRI confirms.​ Severe Skin Reactions: Stevens-Johnson syndrome; rash monitoring critical.​ Baseline neurological assessments and quarterly labs optimize safety.​ Dosage and Administration Guidelines Swallow four 40mg capsules whole once daily at the same time, with or without food, totaling 160mg. No dose reductions below 120mg recommended; hold for grade 3-4 toxicity, resuming at prior dose once resolved. Hepatic impairment (Child-Pugh B/C) warrants caution; renal adjustments unnecessary. Continue indefinitely unless progression or intolerance occurs.​ Precautions and Monitoring Avoid in seizure history without prophylaxis; women (especially pregnant) must not handle due to teratogenicity. Strong CYP2A4 inducers/inhibitors alter exposure—adjust accordingly. Elderly patients face amplified fall risks; annual DEXA scans track bone health. Regular PSA, testosterone, CBC, liver enzymes, and ECGs ensure proactive management.​ Conclusion Enzalutamide 160mg stands as a pivotal advancement in prostate cancer care, offering substantial delays in disease progression, symptom control, and survival gains for patients facing hormone-resistant stages. By meticulously balancing its robust benefits against manageable side effects through vigilant monitoring and supportive measures, individuals regain control over their health journey. Consult oncologists to integrate this therapy seamlessly, tailoring it to personal profiles for optimal, life-extending results Email: info@sterispharma.com / contact@sterispharma.com Call/WhatsApp: 7877551268, 7849827488

Other Specifications

Brand Name :ENZULAMIDE 160
Manufactured By :STERIS HEALTHCARE PVT LTD
Package SIZE :For 7 TABLETS
Storage :Store In A Cool & Dry Place
Counrty :India

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