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CEFEXOTIME DICLOXA Cefixime (200mg), Dicloxacillin ER (500mg) Introduction CEFEXOTIME DICLOXA is a potent antibiotic combination therapy that includes Cefixime (200mg) and Dicloxacillin ER (500mg). This medication is designed to combat a broad spectrum of bacterial infections, leveraging the synergistic effects of both antibiotics to enhance efficacy. Composition Cefixime (200mg): A third-generation cephalosporin antibiotic known for its broad-spectrum activity against Gram-positive and Gram-negative bacteria. It works by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Dicloxacillin ER (500mg): An extended-release form of dicloxacillin, a penicillinase-resistant penicillin. It is particularly effective against penicillinase-producing staphylococci and works by inhibiting cell wall synthesis. Mechanism of Action Cefixime: It binds to penicillin-binding proteins (PBPs) within the bacterial cell wall, disrupting the cross-linking of peptidoglycan chains necessary for cell wall strength and rigidity, resulting in cell lysis. Dicloxacillin: It similarly binds to PBPs, preventing the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, which is crucial for maintaining cell wall integrity. Indications CEFEXOTIME DICLOXA is indicated for the treatment of various bacterial infections, including: Respiratory tract infections (e.g., bronchitis, pneumonia) Urinary tract infections (UTIs) Skin and soft tissue infections Otitis media Sinusitis Bone and joint infections Dosage and Administration The typical dosage for adults is one tablet taken twice daily, with or without food. The duration of treatment depends on the severity and type of infection, usually ranging from 7 to 14 days. It is essential to complete the full course of therapy to prevent the development of antibiotic-resistant bacteria. Side Effects Common side effects may include: Gastrointestinal disturbances (nausea, vomiting, diarrhea) Allergic reactions (rash, itching, anaphylaxis in severe cases) Pseudomembranous colitis Hepatic dysfunction (elevated liver enzymes) Hematologic effects (eosinophilia, neutropenia) Renal toxicity (in rare cases) Precautions Allergy: Patients with a history of allergic reactions to cephalosporins, penicillins, or any other beta-lactam antibiotics should use this medication with caution. Renal Impairment: Dose adjustment may be necessary for patients with renal dysfunction. Pregnancy and Lactation: The safety of this medication in pregnant and breastfeeding women has not been fully established. It should only be used if clearly needed and prescribed by a healthcare provider. Drug Interactions Probenecid: May increase blood levels of Cefixime. Warfarin: Concomitant use can enhance anticoagulant effects, increasing the risk of bleeding. Methotrexate: Cefixime may reduce renal clearance of methotrexate, increasing its toxicity. Oral Contraceptives: Antibiotics may reduce the efficacy of oral contraceptives, suggesting the need for additional contraceptive measures. Conclusion CEFEXOTIME DICLOXA, with its combination of Cefixime and Dicloxacillin, provides a robust treatment option for various bacterial infections. Its broad-spectrum efficacy, combined with the extended-release formulation, ensures a potent and convenient antibiotic therapy. As with all antibiotics, it is crucial to use this medication as prescribed and complete the full course to prevent the emergence of resistant bacteria and achieve optimal therapeutic outcomes. Always consult with a healthcare professional before starting any new medication. For further information: EMAIL: info@sterispharma.com / contact@sterispharma.com CALL/WHATSAPP: 7877551268, 7849827488 Order NOW