Description
Product details
Rifaximin Oral Suspension 100 mg/5 ml is a broad-spectrum, gut-selective antibiotic formulated to treat various bacterial infections of the gastrointestinal tract, including traveler’s diarrhea, hepatic encephalopathy-related symptoms, and irritable bowel syndrome with diarrhea (IBS-D). Its unique non-systemic activity ensures that the drug acts locally in the intestines without significant absorption into the bloodstream, making it both effective and safe for long-term gastrointestinal management. Designed in a pleasant-tasting, easy-to-administer oral suspension form, Rifaximin 100 mg/5 ml is especially suitable for pediatric patients and adults who have difficulty swallowing tablets. It is ideal for treating infections caused by non-invasive strains of Escherichia coli and other enteric bacteria, while also helping maintain intestinal balance and promoting recovery from gut-related complications. Composition Each 5 ml of suspension contains: Rifaximin IP – 100 mg Flavored base and excipients – q.s. Dosage Form: Oral Suspension Appearance: Pink to reddish suspension (depending on brand formulation) Packaging: Available in 30 ml, 60 ml, or 100 ml bottles with a measuring cup for accurate dosing. Pharmacological Action and Mechanism Rifaximin belongs to the rifamycin class of antibiotics and is structurally related to rifampicin. However, it has been specially modified to act locally in the gastrointestinal tract with negligible systemic absorption (<0.4%). Mechanism of Action: Rifaximin inhibits bacterial RNA synthesis by binding to the β-subunit of the bacterial DNA-dependent RNA polymerase. This action prevents the transcription process, thereby stopping bacterial growth and replication. Its broad-spectrum activity covers both gram-positive and gram-negative bacteria, including aerobic and anaerobic strains. Due to poor absorption, it remains in the intestine at high concentrations, providing localized antibacterial effect without systemic toxicity. Additionally, Rifaximin exerts eubiotic effects — it helps restore normal intestinal flora balance by selectively targeting harmful bacteria, which makes it useful for chronic intestinal disorders. Uses and Indications Rifaximin Oral Suspension 100 mg/5 ml is indicated for the following conditions: Traveler’s Diarrhea (TD): Caused by non-invasive strains of Escherichia coli. Helps relieve symptoms like watery stools, abdominal cramps, and bloating within a short duration. Hepatic Encephalopathy (HE): Used as adjunct therapy to reduce ammonia-producing gut bacteria, thereby lowering blood ammonia levels and improving mental status in patients with chronic liver disease. Irritable Bowel Syndrome with Diarrhea (IBS-D): Provides relief from abdominal pain, bloating, and irregular bowel movements by reducing bacterial overgrowth in the small intestine (SIBO). Small Intestinal Bacterial Overgrowth (SIBO): Helps normalize gut flora and reduces gas, bloating, and discomfort caused by bacterial overgrowth. Gastrointestinal Infections in Children: Effective in pediatric patients suffering from infectious diarrhea due to bacterial contamination of food or water. Prophylactic Use: May be prescribed post-surgery or in chronic liver disease to prevent recurrence of infection-related complications. Dosage and Administration Adults and Children (>12 years): Usual dose is 10–20 ml (200–400 mg) every 8–12 hours, depending on the indication and physician’s recommendation. Children (2–12 years): 5–10 ml (100–200 mg) two or three times daily, as directed by a pediatrician. Shake the bottle well before each use. Complete the prescribed course even if symptoms improve early to prevent recurrence and antibiotic resistance. Key Benefits Gut-Selective Action: Acts locally within the intestine without entering systemic circulation, ensuring targeted therapy with minimal side effects. Broad-Spectrum Antibacterial Activity: Effective against a wide range of gram-positive, gram-negative, aerobic, and anaerobic enteric pathogens. Safe for Pediatric and Adult Use: The liquid form allows accurate dosing and ease of administration, especially for children or elderly patients. Minimal Systemic Absorption: Reduces the risk of systemic toxicity and drug interactions compared to conventional antibiotics. Effective for Traveler’s Diarrhea: Rapidly controls diarrhea symptoms caused by E. coli and restores normal intestinal function. Improves Liver Health in Hepatic Encephalopathy: Decreases ammonia-producing bacteria, thereby reducing confusion, lethargy, and other symptoms related to hepatic encephalopathy. Restores Gut Microbiota Balance: Helps maintain healthy intestinal flora, supporting digestion and preventing recurrent infections. Reduces Bloating and Abdominal Discomfort in IBS-D: Provides symptomatic relief and enhances quality of life in patients suffering from chronic bowel irregularities. Low Risk of Resistance: Due to its minimal absorption and targeted mechanism, the development of bacterial resistance is significantly lower. Well-Tolerated Formulation: The oral suspension is gentle on the stomach and has a pleasant taste, improving compliance in children and adults alike. Precautions and Warnings While Rifaximin Oral Suspension is considered safe for most patients, the following precautions should be observed: Allergy: Avoid use in patients with known hypersensitivity to rifaximin, rifampicin, or other rifamycin derivatives. Severe Diarrhea or Bloody Stool: If symptoms worsen or persist beyond 48 hours, consult a physician; may indicate an invasive infection requiring alternative therapy. Liver Impairment: Use with caution in patients with severe hepatic impairment; dosage adjustments may be required. Pregnancy and Lactation: Limited data available; should be used only if clearly needed and prescribed by a doctor. Long-Term Use: Prolonged or unnecessary use may lead to superinfection by non-susceptible organisms, including fungi. Driving and Machinery: Generally safe, but dizziness or fatigue may occur in rare cases. Possible Side Effects Rifaximin is generally well-tolerated due to its localized action in the gut. However, some mild to moderate side effects may occur in sensitive individuals. Common Side Effects: Nausea Flatulence (gas) Abdominal pain or cramping Headache Bloating Constipation Less Common / Rare Side Effects: Skin rash or itching Dizziness or fatigue Elevated liver enzymes (rare) Vomiting or dry mouth Fever or flu-like symptoms Serious Side Effects (Very Rare): Allergic reaction (rash, swelling, or breathing difficulty) Persistent watery or bloody diarrhea Severe abdominal pain If any severe adverse reactions occur, discontinue use and seek medical attention immediately. Storage and Handling Store below 30°C in a cool, dry place. Protect from direct sunlight and freezing. Shake well before use. Keep out of reach of children. Discard any unused portion after the treatment course or expiry date. Conclusion Rifaximin Oral Suspension 100 mg/5 ml is a clinically trusted and patient-friendly antibiotic formulation for the treatment of gastrointestinal infections and liver-related complications. Its unique non-systemic mode of action, combined with broad antibacterial efficacy, makes it an excellent choice for both acute and chronic intestinal disorders. Unlike traditional antibiotics that circulate systemically, Rifaximin works locally within the intestines to eliminate harmful bacteria while preserving the natural gut flora. This results in faster relief from symptoms like diarrhea, bloating, and abdominal discomfort — with minimal side effects. Whether used for traveler’s diarrhea, hepatic encephalopathy, IBS-D, or bacterial overgrowth syndromes, Rifaximin offers targeted, safe, and effective therapy for restoring digestive health and improving overall well-being.
