Description
Product details
Nicorandil Tablets 5 mg is a vasodilatory anti-anginal medication widely prescribed for the management and prevention of angina pectoris (chest pain) associated with coronary artery disease (CAD). Angina results from an imbalance between the heart’s oxygen demand and supply due to restricted blood flow in the coronary arteries. Nicorandil offers a dual mechanism of action — acting both as a nitrate-like vasodilator and a potassium channel opener, making it unique among anti-anginal agents. By improving oxygen delivery to the myocardium and reducing cardiac workload, Nicorandil 5 mg Tablets provide effective relief from anginal pain and reduce the frequency and severity of ischemic episodes. It is also beneficial in preventing future attacks, improving exercise tolerance, and enhancing the overall quality of life in patients with chronic stable angina. Composition Each tablet contains: Nicorandil IP – 5 mg Excipients – q.s. Nicorandil tablets are available in film-coated form to ensure stability, easy swallowing, and optimal absorption. They are manufactured in compliance with Good Manufacturing Practices (GMP) standards to ensure safety, purity, and efficacy. Pharmacological Action / Mechanism of Action Nicorandil exhibits a dual mechanism that makes it distinct among anti-anginal drugs: Nitrate-Like Effect: Nicorandil acts as a nitric oxide (NO) donor. Nitric oxide activates guanylate cyclase, increasing cyclic GMP (cGMP) levels in vascular smooth muscle. This leads to relaxation of blood vessels, particularly veins and large arteries, thereby reducing preload and afterload on the heart. This nitrate-like activity lowers myocardial oxygen demand. Potassium Channel Opening Effect: Nicorandil opens ATP-sensitive potassium (KATP) channels in vascular smooth muscle, resulting in arteriolar vasodilation. This increases coronary blood flow and improves oxygen supply to ischemic heart tissues. Together, these effects reduce cardiac workload, enhance coronary perfusion, and prevent anginal pain by correcting the oxygen supply-demand mismatch in the heart muscle. Uses and Indications Nicorandil Tablets 5 mg are indicated for the treatment and prevention of angina pectoris in adults, particularly: Chronic Stable Angina: Helps reduce the frequency and severity of chest pain associated with exertion or emotional stress. Prophylaxis of Angina Attacks: Used regularly to prevent anginal episodes, especially in patients with known coronary artery disease. Adjunct Therapy in Ischemic Heart Disease (IHD): Can be used alongside beta-blockers, calcium channel blockers, or antiplatelet drugs for enhanced symptom control and long-term protection. Improvement of Exercise Tolerance: Reduces the likelihood of anginal pain during physical activity, enabling patients to perform daily tasks comfortably. In some clinical cases, Nicorandil is also considered for post-myocardial infarction recovery, as it improves coronary perfusion, although this is at the discretion of a cardiologist. Dosage and Administration Recommended Starting Dose: 5 mg to 10 mg twice daily. Maintenance Dose: May be increased gradually to 10–20 mg twice daily, depending on clinical response and tolerance. The tablets should be swallowed whole with water, preferably at the same times each day. Nicorandil should not be stopped abruptly; dosage tapering is recommended to avoid rebound angina. Always follow the dosage instructions provided by the physician. Key Benefits Dual Mechanism for Comprehensive Relief: Combines nitrate-like and potassium channel-opening properties for both arterial and venous dilation, providing superior protection against anginal attacks. Improves Coronary Blood Flow: Dilates coronary arteries, increasing oxygen delivery to ischemic myocardial tissues. Reduces Cardiac Workload: By decreasing preload (venous return) and afterload (arterial resistance), Nicorandil minimizes the heart’s oxygen consumption. Rapid Onset of Action: Nicorandil acts within a short duration, offering quick relief from anginal discomfort. Prevents Future Angina Episodes: Regular use helps maintain steady control of chest pain, improving exercise capacity and quality of life. Compatible with Other Cardiac Medications: Can be safely used alongside antiplatelet agents, beta-blockers, ACE inhibitors, and statins as part of comprehensive cardiac care. Favorable Safety Profile: Compared to nitrates, Nicorandil carries a lower risk of tolerance development, making it suitable for long-term therapy. Enhances Myocardial Protection: Nicorandil’s KATP channel activation provides additional cardioprotective effects by improving microvascular blood flow and limiting ischemic damage during stress. Precautions and Warnings Although Nicorandil is generally well-tolerated, certain precautions are advised: Hypotension: Nicorandil may cause a drop in blood pressure due to vasodilation. Caution is advised in patients with hypotension or dehydration. Concurrent Use with Nitrates: Should not be used together with other nitrate medications to avoid severe hypotension. Oral or Gastrointestinal Ulcers: Rarely, Nicorandil may cause ulcerations in the mouth, intestines, or skin. Treatment should be discontinued if ulceration occurs. Patients with Low Blood Volume: Use cautiously in individuals with hypovolemia or those on diuretics. Driving and Machinery: Dizziness or light-headedness may occur; avoid driving until effects are known. Pregnancy and Lactation: Should be used only if prescribed by a physician when the potential benefits outweigh the risks. Possible Side Effects Nicorandil is generally safe but may cause some side effects, particularly at the start of therapy or with higher doses. Common and rare adverse reactions include: Common Side Effects: Headache (due to vasodilation) Flushing or warmth sensation Dizziness or light-headedness Nausea or mild stomach upset Fatigue or weakness Less Common / Rare Side Effects: Hypotension (low blood pressure) Palpitations or tachycardia Mouth ulcers, anal ulcers, or skin ulceration (uncommon but serious — discontinue if occurs) Rash or allergic reaction Visual disturbances (rare and usually reversible) If any severe reaction or persistent discomfort occurs, medical attention should be sought promptly. Drug Interactions Avoid concomitant use with nitrates or phosphodiesterase type-5 inhibitors (e.g., Sildenafil, Tadalafil), as it may cause a dangerous fall in blood pressure. Caution with antihypertensive drugs or diuretics, which may enhance hypotensive effects. Alcohol consumption can potentiate dizziness or hypotension and should be limited. Storage and Handling Store below 30°C, protected from moisture and direct sunlight. Keep out of reach of children. Do not use tablets past the expiry date or if the packaging is damaged. Conclusion Nicorandil Tablets 5 mg offer a modern and effective approach to managing angina pectoris, providing reliable relief through their dual-action mechanism. By combining nitrate-like vasodilation with potassium channel opening, Nicorandil ensures both oxygen supply improvement and reduction of cardiac workload — the cornerstone of angina management. It is well-tolerated, fast-acting, and suitable for long-term therapy, making it a preferred choice for patients with chronic stable angina. Regular use under medical supervision helps reduce the frequency of chest pain, improve physical endurance, and enhance the overall quality of life in individuals with coronary artery disease.
